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ATG4B (human)

Overview ATG4B Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protease; Autophagy; EC 3.4.22.-; Ubiquitin conjugating system Cellular Component: cytoplasm Molecular Function: protein binding; cysteine-type peptidase activity Biological Process: protein transport; positive regulation of protein catabolic process; autophagy; proteolysis; autophagic vacuole formation Reference #:  Q9Y4P1 (UniProtKB) Alt. Names/Synonyms: APG4 autophagy 4 homolog B; APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); ATG4B; AUT-like 1 cysteine endopeptidase; AUTL1; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; KIAA0943; MGC1353 Gene Symbols: ATG4B Molecular weight: 44,294 Da Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG4B 2CY7 - A=1-393 (human) 2D1I - A/B=1-393 (human) 2Z0D - A=1-354 (human) 2Z0E - A=1-354 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2CY7 2D1I 2Z0D 2Z0E  |  ENZYME  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T7	_MDAATLTyDTLRFA
0	1		Y8-p	MDAATLTyDTLRFAE
0	1		Y122-p	FIDRKDSyySIHQIA
0	1		Y123-p	IDRKDSyySIHQIAQ
0	1		K153-u	NTVAQVLkKLAVFDT
0	1		S262	VIGGKPNSAHYFIGY
0	1		S316-p	SIAELDPsIAVGFFC
0	17		S383-p	RLERFFDsEDEDFEI
0	3		S392-p	DEDFEILsL______

	mouse
T7-p	_MDAATLtYDTLRFA
Y8	MDAATLtYDTLRFAE
Y122	FLDRKDSYYSIHQIA
Y123	LDRKDSYYSIHQIAQ
K153	NTVAQVLKKLAVFDT
S262-p	VIGGKPNsAHYFIGY
S316	GIGELDPSIAVGFFC
S383-p	RLERFFDsEDEDFEI
S392-p	DEDFEILsL______

	rat
-	gap
-	gap
-	gap
-	gap
-	gap
S93	VIGGKPNSAHYFIGY
S147	GIGELDPSIAVGFFC
S214-p	RLERFFDsEDEDFEI
S223	DEDFEILSL______

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