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ARHGAP3 (human)

Overview ARHGAP3 GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: GTPase activating protein, Rac/Rho Cellular Component: membrane; cytosol Molecular Function: SH3/SH2 adaptor activity; Rac GTPase activator activity; metal ion binding; GTPase activator activity Biological Process: acrosome formation; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction Reference #:  P52757 (UniProtKB) Alt. Names/Synonyms: ARHGAP3; BCH; beta chimerin; Beta-chimaerin; Beta-chimerin; chimerin (chimaerin) 2; CHIO; CHN2; MGC138360; Rho GTPase-activating protein 3; rho-GTPase-activating protein 3; RHOGAP3 Gene Symbols: CHN2 Molecular weight: 53,924 Da Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states

Select Structure to View Below ARHGAP3 1XA6 - A=7-468 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: Y21‑p, S171‑p cytoskeletal reorganization: Y153‑p inhibition: Y21‑p, Y153‑p, S171‑p intracellular localization: Y153‑p, S171‑p molecular association, regulation: S171‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S12-p	SNSSLSGsSVSSDAE
1	0		Y21-p	VSSDAEEyQPPIWKS
1	145		Y153-p	KMTTNPIyEHIGyAt
0	22		Y158-p	PIyEHIGyAtLLREK
0	6		T160-p	yEHIGyAtLLREKVs
1	0		S167-p	tLLREKVsRRLsRsK
1	1		S171-p	EKVsRRLsRsKNEPR
1	0		S173-p	VsRRLsRsKNEPRKT
0	2		N181	KNEPRKTNVTHEEHT
0	1		T188	NVTHEEHTAVEKIsS
0	1		S194-p	HTAVEKIsSLVRRAA
0	1		Y211	HNDNHFNYEKTHNFK
0	1		T349-p	YPDINIItGALKLYF

	mouse
S12	SNSSLSGSSVSSDAE
Y21	VSSDAEEYQPPIWKS
Y153-p	KMTTNPIyEHIGYAT
Y158	PIyEHIGYATLLREK
T160	yEHIGYATLLREKVS
S167	TLLREKVSRRLsRSK
S171-p	EKVSRRLsRSKNESR
S173	VSRRLsRSKNESRKA
S181-p	KNESRKAsVSNEEHt
T188-p	sVSNEEHtPVEKISS
S194	HtPVEKISSLVRRAA
Y211-p	HNDNHFNyEKTHNFK
T349	YPDINIITGALKLYF

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