GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs, Rac/Rho; GAPs
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component: membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; metal ion binding; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.