Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ARHGAP3 (human)

Overview
ARHGAP3 GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Rac/Rho
Cellular Component: membrane; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; metal ion binding; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
Reference #:  P52757 (UniProtKB)
Alt. Names/Synonyms: ARHGAP3; BCH; beta chimerin; Beta-chimaerin; Beta-chimerin; chimerin (chimaerin) 2; CHIO; CHN2; MGC138360; Rho GTPase-activating protein 3; rho-GTPase-activating protein 3; RHOGAP3
Gene Symbols: CHN2
Molecular weight: 53,924 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
Select Structure to View Below

ARHGAP3

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Sites Implicated In
cell motility, altered: Y21‑p, S171‑p
cytoskeletal reorganization: Y153‑p
activity, inhibited: Y21‑p, Y153‑p, S171‑p
intracellular localization: Y153‑p, S171‑p
molecular association, regulation: S171‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12-p SNSSLSGsSVSSDAE
1 0 Y21-p VSSDAEEyQPPIWKS
1 147 Y153-p KMTTNPIyEHIGyAt
0 18 Y158-p PIyEHIGyAtLLREK
0 7 T160-p yEHIGyAtLLREKVs
1 0 S167-p tLLREKVsRRLsRsK
1 1 S171-p EKVsRRLsRsKNEPR
1 0 S173-p VsRRLsRsKNEPRKT
0 2 N181 KNEPRKTNVTHEEHT
0 1 T188 NVTHEEHTAVEKIsS
0 1 S194-p HTAVEKIsSLVRRAA
0 1 Y211 HNDNHFNYEKTHNFK
0 1 T349-p YPDINIItGALKLYF
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S58 LFACSQISSLVRRAA
Y75 HNDNHFNYEKTHNFK
T213 YPDINIITGALKLYF
  ARHGAP3 iso5  
S12 SNSSLSGSSVSSDAE
Y21 VSSDAEEYQPPIWKS
Y153-p KMTTNPIyEHIGYAT
Y158 PIyEHIGYATLLREK
T160 yEHIGYATLLREKVS
S167 TLLREKVSRRLsRSK
S171-p EKVSRRLsRSKNESR
S173 VSRRLsRSKNESRKA
S181-p KNESRKAsVSNEEHt
T188-p sVSNEEHtPVEKISS
S194 HtPVEKISSLVRRAA
Y211-p HNDNHFNyEKTHNFK
T349 YPDINIITGALKLYF
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.