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IRF8 (human)

Overview IRF8 Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytosol; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding Biological Process: positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; defense response to bacterium; immune response; myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis Reference #:  Q02556 (UniProtKB) Alt. Names/Synonyms: H-ICSBP; ICSBP; ICSBP1; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; IRF8 Gene Symbols: IRF8 Molecular weight: 48,356 Da Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRF8

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	Sites Implicated In
transcription, altered: Y107‑p, Y110‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		Y107-p	QLDISEPyKVyRIVP
2	0		Y110-p	ISEPyKVyRIVPEEE
0	3		S162	YMGMIKRSPsPPEAC
0	2		S164-p	GMIKRSPsPPEACRS
1	0		Y211	QMVISFYYGGKLVGQ
0	1		K240-u	QPGLPGTkLYGPEGL
0	1		K269-m1	RQRQVTRkLFGHLER
1	0		K312	VCKGRPNKLERDEVV
0	1		Y335	FRELQQFYNSQGRLP
0	1		Y373-p	LVQIEQLyVRQLAEE

	mouse
Y107-p	QLDISEPyKVYRIVP
Y110	ISEPyKVYRIVPEEE
S162-p	YMGMTKRsPsPPEAC
S164-p	GMTKRsPsPPEACRS
Y211-p	QMVISFYyGGKLVGQ
K238	LSQPGLPKLYGPDGL
K267	RQRQVTRKLFGHLER
K310-s	VCKGRPNkLERDEVV
Y333-p	IRELQQFyATQSRLP
Y371	LVQVEQLYARQLVEE

	rat
Y107	QLDISEPYKVYRIVP
Y110	ISEPYKVYRIVPEEE
S162	YMGIAKRSPSPPEAC
S164	GIAKRSPSPPEACRS
Y211	QMVINFYYGGKLVGQ
K238	LSQPGLPKLYGPDGL
K267	RQRQVTRKLFGHLER
K310	VCKGRPNKLERDEVV
Y333	LRDLQQFYATQSRLP
Y371	LVQVEQLYARQMVEE

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