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Protein Page:
IRF8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRF8 Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleolus; cytosol; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding
Biological Process: transcription from RNA polymerase II promoter; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; defense response to bacterium; immune response; myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis
Reference #:  Q02556 (UniProtKB)
Alt. Names/Synonyms: H-ICSBP; ICSBP; ICSBP1; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; IRF8
Gene Symbols: IRF8
Molecular weight: 48,356 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRF8

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y110‑p
transcription, inhibited: Y107‑p, Y110‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 Y107-p QLDISEPyKVyRIVP
2 0 Y110-p ISEPyKVyRIVPEEE
0 4 S162 YMGMIKRSPsPPEAC
0 4 S164-p GMIKRSPsPPEACRS
1 0 Y211 QMVISFYYGGKLVGQ
0 1 K240-ub QPGLPGTkLYGPEGL
0 1 K269-m1 RQRQVTRkLFGHLER
1 0 K312 VCKGRPNKLERDEVV
0 1 Y335 FRELQQFYNSQGRLP
0 2 Y373-p LVQIEQLyVRQLAEE
  mouse

 
Y107-p QLDISEPyKVYRIVP
Y110 ISEPyKVYRIVPEEE
S162-p YMGMTKRsPsPPEAC
S164-p GMTKRsPsPPEACRS
Y211-p QMVISFYyGGKLVGQ
K238 LSQPGLPKLYGPDGL
K267 RQRQVTRKLFGHLER
K310-sm VCKGRPNkLERDEVV
Y333-p IRELQQFyATQSRLP
Y371 LVQVEQLYARQLVEE
  rat

 
Y107 QLDISEPYKVYRIVP
Y110 ISEPYKVYRIVPEEE
S162 YMGIAKRSPSPPEAC
S164 GIAKRSPSPPEACRS
Y211 QMVINFYYGGKLVGQ
K238 LSQPGLPKLYGPDGL
K267 RQRQVTRKLFGHLER
K310 VCKGRPNKLERDEVV
Y333 LRDLQQFYATQSRLP
Y371 LVQVEQLYARQMVEE
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