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Protein Page:
ABCA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCA3 Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3); also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the ABC transporter superfamily. ABCA family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, ABC family; Membrane protein, integral
Cellular Component: extracellular space; membrane; plasma membrane; integral to membrane
Molecular Function: transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding
Biological Process: ATP catabolic process; response to drug; transport; response to glucocorticoid stimulus; transmembrane transport
Reference #:  Q99758 (UniProtKB)
Alt. Names/Synonyms: ABC transporter 3; ABC-C; ABC-C transporter; ABC3; ABCA3; ATP-binding cassette 3; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette, sub-family A (ABC1), member 3; EST111653; LBM180; MGC166979; MGC72201; SMDP3
Gene Symbols: ABCA3
Molecular weight: 191,362 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Select Structure to View Below

ABCA3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y152-p PLPLAVKyHLRFSYT
0 1 T197-p NPGPREPtSPDGGEP
0 1 T239-p RQLFQRLtVtIKRFP
0 1 T241-p LFQRLtVtIKRFPYP
0 1 K243 QRLtVtIKRFPYPPF
0 1 T385-p GGFLYFFtYIPYFFV
0 5 K503 KPRAVAGKEEEDSDP
0 7 K512-ub EEDSDPEkALRNEYF
0 1 K531 EDLVAGIKIKHLSKV
0 1 T575-p NGAGKTTtLSMLTGL
0 1 T586-p LTGLFPPtSGRAYIS
0 1 R605 SQDMVQIRKSLGLCP
0 1 K606 QDMVQIRKSLGLCPQ
0 4 K640 LKGLSRQKCPEEVKQ
0 1 K646 QKCPEEVKQMLHIIG
0 1 K711 WDLLQRQKSDRTIVL
0 8 Y754 SLFLKQKYGAGYHMT
0 1 K812 RFEGLFAKLEKKQKE
0 1 K841 EVFLRVGKLVDSSMD
0 1 S866-p YQHERRAsDWAVDSN
0 1 R1212 GAATAYTRLtIFNIL
0 3 T1214-p ATAYTRLtIFNILsG
0 2 S1220-p LtIFNILsGIATFLM
0 1 T1229-p IATFLMVtIMRIPAV
0 1 Y1265-p GMAVSSFyENyETRR
0 1 Y1268-p VSSFyENyETRRYCT
0 1 Y1349-p RRTLTELytRMPVLP
0 1 T1350-p RTLTELytRMPVLPE
0 1 S1387-p PLIIKELsKVYEQRV
0 1 K1408 RLSLAVQKGECFGLL
0 1 K1422 LGFNGAGKTTTFKML
0 1 T1514-p HANKLVRtysGGNKR
0 1 Y1515-p ANKLVRtysGGNKRK
0 1 S1516-p NKLVRtysGGNKRKL
0 1 K1604 SPQHLKSKFGSGYSL
0 4 Q1620 AKVQSEGQQEALEEF
  mouse

 
Y152 PLPLAVKYHLRFSYT
S197 SPGPREPSSPDGGEP
M239 QQLFQKLMVITkRFP
I241 LFQKLMVITkRFPFP
K243-ac QKLMVITkRFPFPPY
T385 GGFLYFFTYTPYFFV
K503-ub NPRTVVGkEEEGSDP
K512-ub EEGSDPEkALRNEYF
K531-ub EDLVAGIkIKHLSKV
T575 NGAGKTTTMSLLTGL
T586 LTGLFPPTSGHAYIH
R605-m2 SQDMAQIrkSLGLCP
K606-ac QDMAQIrkSLGLCPQ
K640-ub LKGLSLQkCPEEVkQ
K646-ub QkCPEEVkQMLHILS
K711-ub WDLLQQQkSDRTVLL
Y754 SLFLKQKYGAGYHMT
K812-ub RFESLFAkLEKKQKE
K841-ub EVFLRVGkLVDTSMD
S866 YQHERRASDWALDSN
R1212-m1 AASTAYTrLTIFNIL
T1214 STAYTrLTIFNILSG
S1220 LTIFNILSGIATFIM
T1229 IATFIMVTIMRIPAV
Y1265 GMAVSNFYENYETRR
Y1268 VSNFYENYETRRYCT
Q1349 RWTLAELQNRTSVLP
N1350 WTLAELQNRTSVLPE
S1387 PLIINELSKVYDQRA
K1408-ub RISLAVQkGECFGLL
K1422-ub LGFNGAGkTTTFKML
T1514 HANKLVKTYSGGNKR
Y1515 ANKLVKTYSGGNKRK
S1516 NKLVKTYSGGNKRKL
K1604-ub SPQHLKSkFGSGYSL
K1620-ub AKVRSEGkQDALEEF
  rat

 
Y152 PLPLAVRYHLRFSYT
S197 SPGPREPSSPDGGEP
T239 HQLFQKLTVITKRFP
I241 LFQKLTVITKRFPFP
K243 QKLTVITKRFPFPPY
T385 GGFLYFFTYTPYFFV
K503 NPRTVVGKEEEGGDP
K512 EEGGDPEKAFRTEYF
K531 EDLAAGIKIKHLSKV
T575 NGAGKTTTMSMLTGL
T586 LTGLFPPTSGHAYIR
R605 SQDMVQIRKSLGLCP
K606 QDMVQIRKSLGLCPQ
K640 LKGLSVQKCPEEVKQ
K646 QKCPEEVKQMLHTLG
K711 WDLLQQQKSDRTVLL
Y754-p SLFLKQKyGAGYHMT
K812 RFESLFAKLEKKQKE
K841 EVFLRVGKLVDTSMD
S866 YQHERRASDWALDSN
R1212 AASTAYTRLTIFNIL
T1214 STAYTRLTIFNILSG
S1220 LTIFNILSGIATFIV
T1229 IATFIVVTIMRIPAV
Y1265 GMAVSNFYENYETRR
Y1268 VSNFYENYETRRYCT
Q1349 RWTLAELQNRTSVLP
N1350 WTLAELQNRTSVLPE
S1387 PLIINELSKVYDQRA
K1408 RISLAVQKGECFGLL
K1422 LGFNGAGKTTTFKML
- gap
- gap
- gap
K1564 SPQHLKSKFGSGYSL
K1580 AKVRSEGKQEVLEEF
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