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Protein Page:
TOLLIP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TOLLIP Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2. Belongs to the tollip family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein; Vesicle protein
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: nuclear body; interleukin-1 receptor complex; perinuclear region of cytoplasm; cytoplasm; interleukin-18 receptor complex; cytosol
Molecular Function: signal transducer activity; protein binding; SUMO binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; interleukin-1, Type I receptor binding; kinase binding
Biological Process: positive regulation of protein sumoylation; cell-cell signaling; epithelial cell differentiation; innate immune response; signal transduction; inflammatory response; phosphorylation; leukocyte activation
Reference #:  Q9H0E2 (UniProtKB)
Alt. Names/Synonyms: adapter protein; FLJ33531; IL-1RAcPIP; TOLIP; toll interacting protein; Toll-interacting protein; TOLLIP
Gene Symbols: TOLLIP
Molecular weight: 30,282 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TOLLIP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MATTVsTQRGPVy
0 4 Y13-p sTQRGPVyIGELPQD
0 4 Y45-p QAAQQLQyGGAVGTV
0 61 K63-ub NITVVQAkLAkNyGM
0 22 K66-ub VVQAkLAkNyGMtRM
0 1 Y68-p QAkLAkNyGMtRMDP
0 1 T71-p LAkNyGMtRMDPyCR
0 1 Y76-p GMtRMDPyCRLRLGy
0 2 Y83-p yCRLRLGyAVyETPT
0 2 Y86-p LRLGyAVyETPTAHN
0 17 K96-ub PTAHNGAkNPRWNKV
0 31 R143 ITIPESLRQGkVEDk
0 10 K146-ub PESLRQGkVEDkWYS
0 3 K150-ub RQGkVEDkWYSLSGR
0 1 S171-p GMINLVMsYALLPAA
0 1 K235-ac RCSEEDLkAIQDMFP
0 8 K235-ub RCSEEDLkAIQDMFP
  mouse

 
S6 __MATTVSTQRGPVY
Y13 STQRGPVYIGELPQD
Y45 QAAQQLQYGGTVGTV
K63-ub SITVVQAkLAkNYGM
K66-ub VVQAkLAkNYGMTRM
Y68 QAkLAkNYGMTRMDP
T71 LAkNYGMTRMDPYCR
Y76 GMTRMDPYCRLRLGY
Y83 YCRLRLGYAVYETPT
Y86 LRLGYAVYETPTAHN
K96-ub PTAHNGAkNPRWNKV
K143-ub ITIPESLkQGQVEDE
Q146 PESLkQGQVEDEWYS
E150 kQGQVEDEWYSLSGR
S171 GMINLVMSYTSLPAA
K235 RCNEEDLKAIQDMFP
K235-ub RCNEEDLkAIQDMFP
  rat

 
S6 __MATTVSTQRGPVy
Y13-p STQRGPVyIGELPQD
Y45 QAAQQLQYGGAVGTV
K63 SITVVQAKLAkNYGM
K66-ub VVQAKLAkNYGMTRM
Y68 QAKLAkNYGMTRMDP
T71 LAkNYGMTRMDPYCR
Y76 GMTRMDPYCRLRLGY
Y83 YCRLRLGYAVYETPT
Y86 LRLGYAVYETPTAHN
K96-ub PTAHNGAkNPRWNKV
K143-ub ITIPESLkQGQVEDE
Q146 PESLkQGQVEDEWYS
E150 kQGQVEDEWYSLSGR
S171 GMINLVMSYTSLPAA
K235 RCNEEDLKAIQDMFP
K235 RCNEEDLKAIQDMFP
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