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TOLLIP (human)

Overview TOLLIP Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2. Belongs to the tollip family. Note: This description may include information from UniProtKB. Protein type: Vesicle protein; Inhibitor protein Cellular Component: interleukin-1 receptor complex; cytoplasm; interleukin-18 receptor complex; cytosol Molecular Function: signal transducer activity; protein binding; kinase binding Biological Process: cell-cell signaling; innate immune response; signal transduction; inflammatory response; phosphorylation; leukocyte activation Reference #:  Q9H0E2 (UniProtKB) Alt. Names/Synonyms: adapter protein; FLJ33531; IL-1RAcPIP; TOLIP; toll interacting protein; Toll-interacting protein; TOLLIP Gene Symbols: TOLLIP Molecular weight: 30,282 Da Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states CST Pathways:  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TOLLIP 1WGL - A=229-274 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S6-p	__MATTVsTQRGPVy
0	4		Y13-p	sTQRGPVyIGELPQD
0	4		Y45-p	QAAQQLQyGGAVGTV
0	61		K63-u	NITVVQAkLAkNyGM
0	22		K66-u	VVQAkLAkNyGMtRM
0	1		Y68-p	QAkLAkNyGMtRMDP
0	1		T71-p	LAkNyGMtRMDPyCR
0	1		Y76-p	GMtRMDPyCRLRLGy
0	1		Y83-p	yCRLRLGyAVyETPT
0	2		Y86-p	LRLGyAVyETPTAHN
0	17		K96-u	PTAHNGAkNPRWNKV
0	31		R143	ITIPESLRQGkVEDk
0	10		K146-u	PESLRQGkVEDkWYS
0	3		K150-u	RQGkVEDkWYSLSGR
0	1		S171-p	GMINLVMsYALLPAA
0	1		K235-a	RCSEEDLkAIQDMFP
0	8		K235-u	RCSEEDLkAIQDMFP

	mouse
S6	__MATTVSTQRGPVY
Y13	STQRGPVYIGELPQD
Y45	QAAQQLQYGGTVGTV
K63-u	SITVVQAkLAkNYGM
K66-u	VVQAkLAkNYGMTRM
Y68	QAkLAkNYGMTRMDP
T71	LAkNYGMTRMDPYCR
Y76	GMTRMDPYCRLRLGY
Y83	YCRLRLGYAVYETPT
Y86	LRLGYAVYETPTAHN
K96-u	PTAHNGAkNPRWNKV
K143-u	ITIPESLkQGQVEDE
Q146	PESLkQGQVEDEWYS
E150	kQGQVEDEWYSLSGR
S171	GMINLVMSYTSLPAA
K235	RCNEEDLKAIQDMFP
K235-u	RCNEEDLkAIQDMFP

	rat
S6	__MATTVSTQRGPVy
Y13-p	STQRGPVyIGELPQD
Y45	QAAQQLQYGGAVGTV
K63	SITVVQAKLAkNYGM
K66-u	VVQAKLAkNYGMTRM
Y68	QAKLAkNYGMTRMDP
T71	LAkNYGMTRMDPYCR
Y76	GMTRMDPYCRLRLGY
Y83	YCRLRLGYAVYETPT
Y86	LRLGYAVYETPTAHN
K96-u	PTAHNGAkNPRWNKV
K143-u	ITIPESLkQGQVEDE
Q146	PESLkQGQVEDEWYS
E150	kQGQVEDEWYSLSGR
S171	GMINLVMSYTSLPAA
K235	RCNEEDLKAIQDMFP
K235	RCNEEDLKAIQDMFP

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