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Protein Page:
WDR5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WDR5 a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus; histone acetyltransferase complex
Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone acetyltransferase activity (H4-K16 specific)
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; histone H3-K4 methylation; skeletal development
Reference #:  P61964 (UniProtKB)
Alt. Names/Synonyms: BIG-3; BIG3; BMP2-induced 3-kb gene protein; SWD3; SWD3, Set1c WD40 repeat protein, homolog; WD repeat domain 5; WD repeat-containing protein 5; WD-repeat protein 5; WDR5
Gene Symbols: WDR5
Molecular weight: 36,588 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WDR5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T18-p EAARAQPtPSSSATQ
0 2 K27-ub SSSATQSkPTPVkPN
0 1 K32-ub QSkPTPVkPNYALKF
0 1 T45 KFTLAGHTKAVSSVK
0 1 S49 AGHTKAVSSVKFsPN
0 1 S50 GHTKAVSSVKFsPNG
0 1 S54-p AVSSVKFsPNGEWLA
0 2 K112-ac ASDDKTLkIWDVSSG
0 8 K120 IWDVSSGKCLKTLKG
0 2 Y131-p TLKGHSNyVFCCNFN
0 2 K159-ub SVRIWDVkTGKCLKT
0 2 K227-ub VKFSPNGkYILAATL
  mouse

 
T18 EAARAQPTPSSSATQ
K27-ub SSSATQSkPTPVKPN
K32 QSkPTPVKPNYALKF
T45-p KFTLAGHtKAVssVK
S49-p AGHtKAVssVKFSPN
S50-p GHtKAVssVKFSPNG
S54 AVssVKFSPNGEWLA
K112 ASDDKTLKIWDVSSG
K120-ub IWDVSSGkCLKTLKG
Y131 TLKGHSNYVFCCNFN
K159-ub SVRIWDVkTGKCLKT
K227-ub VKFSPNGkYILAATL
  rat

 
T18 EAARAQPTPSSSATQ
K27 SSSATQSKPTPVKPN
K32 QSKPTPVKPNYALKF
T45 KFTLAGHTKAVSSVK
S49 AGHTKAVSSVKFSPN
S50 GHTKAVSSVKFSPNG
S54 AVSSVKFSPNGEWLA
K112 ASDDKTLKIWDVSSG
K120 IWDVSSGKCLKTLKG
Y131 TLKGHSNYVFCCNFN
K159 SVRIWDVKTGKCLKT
K227 VKFSPNGKYILAATL
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