DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Interacts with EXO1 and MLH1. High expression in heart, lung, skeletal muscle and kidney, low expression in brain. Belongs to the helicase family. RecQ subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; EC 3.6.1.-; DNA repair, damage; Helicase
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: membrane; nucleolus; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA helicase activity; DNA binding; ATP-dependent 3'-5' DNA helicase activity; ATP binding
Biological Process: ATP catabolic process; DNA strand renaturation; DNA replication; DNA repair; DNA duplex unwinding; DNA recombination
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.