a singhle-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases. Regulates cadherin-dependent contact inhibition. Interacts with EGFR, HER2, -3, and -4. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, regulatory subunit
Alt. Names/Synonyms: DKFZp586O1624; leucine-rich repeat protein LRIG1; leucine-rich repeats and immunoglobulin-like domains 1; Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1; LIG1; LRIG1; ortholog of mouse integral membrane glycoprotein LIG-1
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.