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Protein Page:
LRIG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LRIG1 a singhle-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases. Regulates cadherin-dependent contact inhibition. Interacts with EGFR, HER2, -3, and -4. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Membrane protein, integral
Cellular Component: integral to membrane
Reference #:  Q96JA1 (UniProtKB)
Alt. Names/Synonyms: DKFZp586O1624; leucine-rich repeat protein LRIG1; leucine-rich repeats and immunoglobulin-like domains 1; Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1; LIG1; LRIG1; ortholog of mouse integral membrane glycoprotein LIG-1
Gene Symbols: LRIG1
Molecular weight: 119,113 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LRIG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S236-p LTFQGLNsLEVLKLQ
0 4 S259-p DGAFWGLsKMHVLHL
0 1 S331-p EESLAELssLsVLRL
0 1 S332-p ESLAELssLsVLRLS
0 1 S334-p LAELssLsVLRLSHN
0 2 T594-p YSHKARLtVNVLPsF
0 1 S600-p LtVNVLPsFtKTPHD
0 1 T602-p VNVLPsFtKTPHDIT
0 1 T623-ga ARLECAAtGHPNPQI
0 17 Y941-p CNTEVDCySRGQAFH
0 1 T983 PHHQCSRTAAGSCPE
0 3 Y996-p PECQGSLyPSNHDRM
0 2 Y1029-p SWTLARLyHPDSTEL
0 21 Y1054-p PERAEAQyLLVSNGH
0 1 S1093-p PLLLAPKs_______
  mouse

 
S238 LTFQGLDSLEVLRLQ
S261 DGAFWGLSKMHVLHL
S333 EESLAELSSLSILRL
S334 ESLAELSSLSILRLS
S336 LAELSSLSILRLSHN
T596-p YSHKARLtVNVLPSF
S602 LtVNVLPSFTKIPHD
T604 VNVLPSFTKIPHDIA
T625 ARLECAATGHPNPQI
Y940 DCSTDTAYHPQPVPR
T976-p PHHPYSGtADGSHTL
Y989 TLSGGSLYPSNHDRI
H1021 SWTLAKLHEADCIDL
H1052 AISTEAQHLLVSNGH
S1091 PLLLAPRS_______
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