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PDLIM2 (human)

Overview PDLIM2 Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ubiquitin ligase; Cell adhesion Cellular Component: cortical actin cytoskeleton; focal adhesion; cell surface; stress fiber; nucleus; actin cytoskeleton Molecular Function: zinc ion binding; muscle alpha-actinin binding; myosin heavy chain binding Reference #:  Q96JY6 (UniProtKB) Alt. Names/Synonyms: FLJ34715; MYSTIQUE; PDLI2; PDLIM2; PDZ and LIM domain 2 (mystique); PDZ and LIM domain protein 2; PDZ-LIM protein mystique; SLIM Gene Symbols: PDLIM2 Molecular weight: 37,459 Da Basal Isoelectric point: 9  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDLIM2 2PA1 - A=1-82 (human) 3PDV - A=1-83 (human) 1VB7 - A=3-83 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2PA1 3PDV  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		S72-p	AQSKIRQsPsPLRLQ
0	2		S74-p	SKIRQsPsPLRLQLD
0	1		S83-p	LRLQLDRsQATsPGQ
0	1		A85	LQLDRsQATsPGQTN
0	1		S87-p	LDRsQATsPGQTNGD
0	1		Y111-p	FQGSVRTyTEsQSsL
0	2		S114-p	SVRTyTEsQSsLRss
0	3		S117-p	TyTEsQSsLRssyss
0	2		S120-p	EsQSsLRssyssPtS
0	7		S121-p	sQSsLRssyssPtSL
0	10		Y122-p	QSsLRssyssPtSLs
0	4		S123-p	SsLRssyssPtSLsP
0	18		S124-p	sLRssyssPtSLsPR
0	4		T126-p	RssyssPtSLsPRAG
0	2		S127	ssyssPtSLsPRAGs
0	23		S129-p	yssPtSLsPRAGsPF
0	53		S134-p	SLsPRAGsPFsPPPs
1	29		S137-p	PRAGsPFsPPPssss
1	8		P138	RAGsPFsPPPssssL
0	6		S141-p	sPFsPPPssssLtGE
0	4		S142-p	PFsPPPssssLtGEA
0	7		S143-p	FsPPPssssLtGEAA
0	6		S144-p	sPPPssssLtGEAAI
0	7		T146-p	PPssssLtGEAAISR
0	4		S161-p	SFQSLACsPGLPAAD
0	2		S171-p	LPAADRLsysGRPGS
0	15		Y172-p	PAADRLsysGRPGSR
0	1		S173-p	AADRLsysGRPGSRQ
0	60		S197-p	AVLVLPPsPGPRsSR
0	9		S202-p	PPsPGPRsSRPSMDS
0	9		S203	PsPGPRsSRPSMDSE
0	3		S209	sSRPSMDSEGGSLLL
0	9		S213	SMDSEGGSLLLDEDS
0	2		S239-p	GRAAPRQsssFRLLQ
0	2		S240-p	RAAPRQsssFRLLQE
0	18		S241-p	AAPRQsssFRLLQEA
0	14		T257-p	EAEERGGtPAFLPsS
0	4		S263-p	GtPAFLPsSLsPQSS
0	10		S266-p	AFLPsSLsPQSSLPA
0	5		T279-p	PASRALAtPPkLHTC
0	4		K282-a	RALAtPPkLHTCEKC
0	1		-	gap

	PDLIM2 iso3
S72	AQSKIRQSPSPLRLQ
S74	SKIRQSPSPLRLQLD
S83	LRLQLDRSQATSPGQ
A85	LQLDRSQATSPGQTN
S87	LDRSQATSPGQTNGD
Y111	FQGSVRTYTESQSSL
S114	SVRTYTESQSSLRSS
S117	TYTESQSSLRSSYSS
S120	ESQSSLRSSYSSPTS
S121	SQSSLRSSYSSPTSL
Y122	QSSLRSSYSSPTSLS
S123	SSLRSSYSSPTSLSP
S124	SLRSSYSSPTSLSPR
T126	RSSYSSPTSLSPRAG
S127	SSYSSPTSLSPRAGS
S129	YSSPTSLSPRAGSPF
S134	SLSPRAGSPFSPPPS
S137	PRAGSPFSPPPSSSS
P138	RAGSPFSPPPSSSSL
S141	SPFSPPPSSSSLTGE
S142	PFSPPPSSSSLTGEA
S143	FSPPPSSSSLTGEAA
S144	SPPPSSSSLTGEAAI
T146	PPSSSSLTGEAAISR
S161	SFQSLACSPGLPAAD
S171	LPAADRLSYSGRPGS
Y172	PAADRLSYSGRPGSR
S173	AADRLSYSGRPGSRQ
S197	AVLVLPPSPGPRSSR
S202	PPSPGPRSSRPSMDS
S203	PSPGPRSSRPSMDSE
S209	SSRPSMDSEGGSLLL
S213	SMDSEGGSLLLDEDS
S239	GRAAPRQSSSFRLLQ
S240	RAAPRQSSSFRLLQE
S241	AAPRQSSSFRLLQEA
T257	EAEERGGTPAFLPSS
S263	GTPAFLPSSLSPQSS
S266	AFLPSSLSPQSSLPA
T279	PASRALATPPKLHTC
K282	RALATPPKLHTCEKC
S365-p	TRRPIQPsW______

	mouse
S72-p	AQSKIRQsAsPLRLQ
S74-p	SKIRQsAsPLRLQLD
S83	LRLQLDRSQtASPGQ
T85-p	LQLDRSQtASPGQTN
S87	LDRSQtASPGQTNGE
H111	FQGSLRTHRDsQSSQ
S114-p	SLRTHRDsQSSQRsA
S117	THRDsQSSQRsACFs
S120-p	DsQSSQRsACFsPVs
A121	sQSSQRsACFsPVsL
C122	QSSQRsACFsPVsLs
F123	SSQRsACFsPVsLsP
S124-p	SQRsACFsPVsLsPR
V126	RsACFsPVsLsPRPC
S127-p	sACFsPVsLsPRPCs
S129-p	CFsPVsLsPRPCsPF
S134-p	sLsPRPCsPFstPPP
S137-p	PRPCsPFstPPPtsP
T138-p	RPCsPFstPPPtsPV
P141	sPFstPPPtsPVALs
T142-p	PFstPPPtsPVALsK
S143-p	FstPPPtsPVALsKE
A146	PPPtsPVALsKEDMI
S148-p	PtsPVALsKEDMIGC
S163	SFQSLTHSPGLAAAH
T173	LAAAHHLTYPGHPTS
Y174	AAAHHLTYPGHPTSQ
P175	AAHHLTYPGHPTSQQ
S199-p	AVRVLLHsPGRPssP
S204-p	LHsPGRPssPRFssL
S205-p	HsPGRPssPRFssLD
S209-p	RPssPRFssLDLEED
S210-p	PssPRFssLDLEEDS
S236	GRAAPRQSSsFRLLQ
S237	RAAPRQSSsFRLLQE
S238-p	AAPRQSSsFRLLQEA
T254	EAEERGGTPAFVPSS
S260	GTPAFVPSSLSSQAS
S263	AFVPSSLSSQASLPT
T276-p	PTSRALAtPPKLHTC
K279	RALAtPPKLHTCEKC
-	gap

	rat
S72	AQSKIRQSASPLRLQ
S74	SKIRQSASPLRLQLD
S83	LRLQLDRSQTASPGQ
T85	LQLDRSQTASPGQIN
S87	LDRSQTASPGQINGE
H111	FQGSLRTHHNSQSSQ
S114	SLRTHHNSQSSQRSA
S117	THHNSQSSQRSACFS
S120	NSQSSQRSACFSPAS
A121	SQSSQRSACFSPASL
C122	QSSQRSACFSPASLS
F123	SSQRSACFSPASLSP
S124	SQRSACFSPASLSPR
A126	RSACFSPASLSPRPD
S127	SACFSPASLSPRPDS
S129	CFSPASLSPRPDSPF
S134	SLSPRPDSPFSTPPP
S137	PRPDSPFSTPPPTSP
T138	RPDSPFSTPPPTSPI
P141	SPFSTPPPTSPIALS
T142	PFSTPPPTSPIALSG
S143	FSTPPPTSPIALSGE
A146	PPPTSPIALSGENVI
S148	PTSPIALSGENVIGC
S163	SFQSLTHSPGLAATH
T173	LAATHHLTYPGQPTS
Y174	AATHHLTYPGQPTSQ
P175	ATHHLTYPGQPTSQQ
S199-p	TVRVLLHsPGRPssP
S204-p	LHsPGRPssPRLSSL
S205-p	HsPGRPssPRLSSLD
S209	RPssPRLSSLDLEED
S210	PssPRLSSLDLEEDS
S236	GRAAPRQSSSFRLLQ
S237	RAAPRQSSSFRLLQE
S238	AAPRQSSSFRLLQEA
T254	EAEERGGTPAFVPSS
S260	GTPAFVPSSLSPKAS
S263	AFVPSSLSPKASLPT
T276	PTSRALATPPKLHTC
K279	RALATPPKLHTCEKC
-	gap

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