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Protein Page:
PDLIM2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDLIM2 Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: focal adhesion; cytoplasm; nucleus; actin cytoskeleton
Molecular Function: zinc ion binding; filamin binding; muscle alpha-actinin binding; myosin heavy chain binding
Reference #:  Q96JY6 (UniProtKB)
Alt. Names/Synonyms: FLJ34715; MYSTIQUE; PDLI2; PDLIM2; PDZ and LIM domain 2 (mystique); PDZ and LIM domain protein 2; PDZ-LIM protein mystique; SLIM
Gene Symbols: PDLIM2
Molecular weight: 37,459 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDLIM2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 S72-p AQSKIRQsPsPLRLQ
0 5 S74-p SKIRQsPsPLRLQLD
0 3 S83-p LRLQLDRsQATsPGQ
0 1 A85 LQLDRsQATsPGQTN
0 5 S87-p LDRsQATsPGQTNGD
0 1 Y111-p FQGSVRTyTEsQSsL
0 3 S114-p SVRTyTEsQSsLRss
0 3 S117-p TyTEsQSsLRssyss
0 2 S120-p EsQSsLRssyssPts
0 7 S121-p sQSsLRssyssPtsL
0 9 Y122-p QSsLRssyssPtsLs
0 4 S123-p SsLRssyssPtsLsP
0 17 S124-p sLRssyssPtsLsPR
0 5 T126-p RssyssPtsLsPRAG
0 3 S127-p ssyssPtsLsPRAGs
0 24 S129-p yssPtsLsPRAGsPF
0 55 S134-p sLsPRAGsPFsPPPs
1 30 S137-p PRAGsPFsPPPssss
1 9 P138 RAGsPFsPPPssssL
0 6 S141-p sPFsPPPssssLtGE
0 5 S142-p PFsPPPssssLtGEA
0 8 S143-p FsPPPssssLtGEAA
0 7 S144-p sPPPssssLtGEAAI
0 7 T146-p PPssssLtGEAAISR
0 1 S154-p GEAAISRsFQSLACs
0 6 S161-p sFQSLACsPGLPAAD
0 4 S171-p LPAADRLsysGRPGs
0 14 Y172-p PAADRLsysGRPGsR
0 1 S173-p AADRLsysGRPGsRQ
0 1 S178-p sysGRPGsRQAGLGR
0 61 S197-p AVLVLPPsPGPRsSR
0 10 S202-p PPsPGPRsSRPsMDs
0 10 S203 PsPGPRsSRPsMDsE
0 2 S206-p GPRsSRPsMDsEGGs
0 4 S209-p sSRPsMDsEGGsLLL
0 11 S213-p sMDsEGGsLLLDEDs
0 1 S220-p sLLLDEDsEVFKMLQ
0 3 S239-p GRAAPRQsssFRLLQ
0 2 S240-p RAAPRQsssFRLLQE
0 19 S241-p AAPRQsssFRLLQEA
0 14 T257-p EAEERGGtPAFLPss
0 4 S263-p GtPAFLPssLsPQsS
0 1 S264-p tPAFLPssLsPQsSL
0 15 S266-p AFLPssLsPQsSLPA
0 1 S269-p PssLsPQsSLPASRA
0 7 T279-p PASRALAtPPkLHTC
0 5 K282-ac RALAtPPkLHTCEKC
0 1 Y342-p EKHARQRysAPATLS
0 1 S343-p KHARQRysAPATLSS
0 1 - gap
  PDLIM2 iso3  
S72 AQSKIRQSPSPLRLQ
S74 SKIRQSPSPLRLQLD
S83 LRLQLDRSQATSPGQ
A85 LQLDRSQATSPGQTN
S87 LDRSQATSPGQTNGD
Y111 FQGSVRTYTESQSSL
S114 SVRTYTESQSSLRSS
S117 TYTESQSSLRSSYSS
S120 ESQSSLRSSYSSPTS
S121 SQSSLRSSYSSPTSL
Y122 QSSLRSSYSSPTSLS
S123 SSLRSSYSSPTSLSP
S124 SLRSSYSSPTSLSPR
T126 RSSYSSPTSLSPRAG
S127 SSYSSPTSLSPRAGS
S129 YSSPTSLSPRAGSPF
S134 SLSPRAGSPFSPPPS
S137 PRAGSPFSPPPSSSS
P138 RAGSPFSPPPSSSSL
S141 SPFSPPPSSSSLTGE
S142 PFSPPPSSSSLTGEA
S143 FSPPPSSSSLTGEAA
S144 SPPPSSSSLTGEAAI
T146 PPSSSSLTGEAAISR
S154 GEAAISRSFQSLACS
S161 SFQSLACSPGLPAAD
S171 LPAADRLSYSGRPGS
Y172 PAADRLSYSGRPGSR
S173 AADRLSYSGRPGSRQ
S178 SYSGRPGSRQAGLGR
S197 AVLVLPPSPGPRSSR
S202 PPSPGPRSSRPSMDS
S203 PSPGPRSSRPSMDSE
S206 GPRSSRPSMDSEGGS
S209 SSRPSMDSEGGSLLL
S213 SMDSEGGSLLLDEDS
S220 SLLLDEDSEVFKMLQ
S239 GRAAPRQSSSFRLLQ
S240 RAAPRQSSSFRLLQE
S241 AAPRQSSSFRLLQEA
T257 EAEERGGTPAFLPSS
S263 GTPAFLPSSLSPQSS
S264 TPAFLPSSLSPQSSL
S266 AFLPSSLSPQSSLPA
S269 PSSLSPQSSLPASRA
T279 PASRALATPPKLHTC
K282 RALATPPKLHTCEKC
- gap
- gap
S365-p TRRPIQPsW______
  mouse

 
S72-p AQSKIRQsAsPLRLQ
S74-p SKIRQsAsPLRLQLD
S83 LRLQLDRSQtAsPGQ
T85-p LQLDRSQtAsPGQTN
S87-p LDRSQtAsPGQTNGE
H111 FQGSLRTHRDsQSSQ
S114-p SLRTHRDsQSSQRsA
S117 THRDsQSSQRsACFs
S120-p DsQSSQRsACFsPVs
A121 sQSSQRsACFsPVsL
C122 QSSQRsACFsPVsLs
F123 SSQRsACFsPVsLsP
S124-p SQRsACFsPVsLsPR
V126 RsACFsPVsLsPRPC
S127-p sACFsPVsLsPRPCs
S129-p CFsPVsLsPRPCsPF
S134-p sLsPRPCsPFstPPP
S137-p PRPCsPFstPPPtsP
T138-p RPCsPFstPPPtsPV
P141 sPFstPPPtsPVALs
T142-p PFstPPPtsPVALsK
S143-p FstPPPtsPVALsKE
A146 PPPtsPVALsKEDMI
S148-p PtsPVALsKEDMIGC
S156 KEDMIGCSFQSLTHS
S163 SFQSLTHSPGLAAAH
T173 LAAAHHLTYPGHPTS
Y174 AAAHHLTYPGHPTSQ
P175 AAHHLTYPGHPTSQQ
S180 TYPGHPTSQQAGHSS
S199-p AVRVLLHsPGRPssP
S204-p LHsPGRPssPRFssL
S205-p HsPGRPssPRFssLD
R207 PGRPssPRFssLDLE
S209-p RPssPRFssLDLEED
S210-p PssPRFssLDLEEDS
S217 sLDLEEDSEVFKMLQ
S236 GRAAPRQSSsFRLLQ
S237 RAAPRQSSsFRLLQE
S238-p AAPRQSSsFRLLQEA
T254 EAEERGGTPAFVPSS
S260 GTPAFVPSSLSSQAS
S261 TPAFVPSSLSSQASL
S263 AFVPSSLSSQASLPT
A266 PSSLSSQASLPTSRA
T276-p PTSRALAtPPKLHTC
K279 RALAtPPKLHTCEKC
Y339 EKHARQRYSMPGTLN
S340 KHARQRYSMPGTLNS
- gap
  rat

 
S72 AQSKIRQSASPLRLQ
S74 SKIRQSASPLRLQLD
S83 LRLQLDRSQTASPGQ
T85 LQLDRSQTASPGQIN
S87 LDRSQTASPGQINGE
H111 FQGSLRTHHNSQSSQ
S114 SLRTHHNSQSSQRSA
S117 THHNSQSSQRSACFS
S120 NSQSSQRSACFSPAS
A121 SQSSQRSACFSPASL
C122 QSSQRSACFSPASLS
F123 SSQRSACFSPASLSP
S124 SQRSACFSPASLSPR
A126 RSACFSPASLSPRPD
S127 SACFSPASLSPRPDS
S129 CFSPASLSPRPDSPF
S134 SLSPRPDSPFSTPPP
S137 PRPDSPFSTPPPTSP
T138 RPDSPFSTPPPTSPI
P141 SPFSTPPPTSPIALS
T142 PFSTPPPTSPIALSG
S143 FSTPPPTSPIALSGE
A146 PPPTSPIALSGENVI
S148 PTSPIALSGENVIGC
S156 GENVIGCSFQSLTHS
S163 SFQSLTHSPGLAATH
T173 LAATHHLTYPGQPTS
Y174 AATHHLTYPGQPTSQ
P175 ATHHLTYPGQPTSQQ
S180 TYPGQPTSQQAGHSS
S199-p TVRVLLHsPGRPssP
S204-p LHsPGRPssPRLSsL
S205-p HsPGRPssPRLSsLD
R207 PGRPssPRLSsLDLE
S209 RPssPRLSsLDLEED
S210-p PssPRLSsLDLEEDS
S217 sLDLEEDSEVFKMLQ
S236 GRAAPRQSSSFRLLQ
S237 RAAPRQSSSFRLLQE
S238 AAPRQSSSFRLLQEA
T254 EAEERGGTPAFVPSS
S260 GTPAFVPSSLsPKAS
S261 TPAFVPSSLsPKASL
S263-p AFVPSSLsPKASLPT
A266 PSSLsPKASLPTSRA
T276 PTSRALATPPKLHTC
K279 RALATPPKLHTCEKC
Y339 EKHARQRYSMPGTLS
S340 KHARQRYSMPGTLSS
- gap
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