Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 22q11.1
Cellular Component: integral to plasma membrane; extracellular region
Molecular Function: protein binding; interleukin-17 receptor activity
Biological Process: cell surface receptor linked signal transduction; positive regulation of interleukin-23 production; cytokine and chemokine mediated signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.