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Protein Page:
Brachyury (human)

Overview
Brachyury Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Genetic variations in T are associated with susceptibility to neural tube defects (NTD). NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis. T is involved in susceptibility to the development of chordoma (CHDM). Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Susceptibility to development of chordomas is due to a T gene duplication. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Cell cycle regulation; DNA binding protein; Motility/polarity/chemotaxis
Cellular Component: nuclear chromatin; cytoplasm
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; heart morphogenesis; somitogenesis; neural plate morphogenesis; embryonic skeletal development; mesoderm migration; notochord formation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; signal transduction; BMP signaling pathway; determination of anterior/posterior axis, embryo; neural tube closure; positive regulation of cell proliferation; penetration of zona pellucida; mesoderm development; vasculogenesis
Reference #:  O15178 (UniProtKB)
Alt. Names/Synonyms: BRAC; brachyury protein; MGC104817; OTTHUMP00000017588; T; T brachyury; T brachyury-like; T, brachyury homolog (mouse); TFT; transcription factor T
Gene Symbols: T
Molecular weight: 47,443 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Brachyury

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S431-p IASWTPVsPPSM___
  mouse

 
S432 IASWTPVSPPSM___
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