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SAG (human)

Overview SAG Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Retina and pineal gland. Belongs to the arrestin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; G protein regulator, misc. Molecular Function: opsin binding; phosphoprotein binding; protein phosphatase inhibitor activity Biological Process: rhodopsin mediated signaling; cell surface receptor linked signal transduction; visual perception Reference #:  P10523 (UniProtKB) Alt. Names/Synonyms: 48 kDa protein; arrestin 1; ARRS; DKFZp686D1084; DKFZp686I1383; retina and pineal gland (arrestin); Retinal S-antigen; retinal S-antigen (48 KDa protein); Rod photoreceptor arrestin; RP47; S-AG; S-antigen; S-arrestin; SAG Gene Symbols: SAG Molecular weight: 45,120 Da Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SAG 1AYR - A/B/C/D=1-367 (cow) 1CF1 - A/B/C/D=2-404 (cow) 1Y6Y - B=10-362 (cow) 3UGU - A=1-369 (cow) 3UGX - A/B/C/D=1-404 (cow) 4J2Q - A/B=1-369 (cow)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K9-a	AASGKTSkSEPNHVI
0	1		S10	ASGKTSkSEPNHVIF
0	1		Y29-p	RDKSVTIyLGNRDYI
0	1		Y62-p	LVKGKKVyVtLtCAF
0	1		T64-p	KGKKVyVtLtCAFRY
0	1		T66-p	KKVyVtLtCAFRYGQ
0	1		Y120-p	KKLGSNTyPFLLTFP
0	1		Y129-p	FLLTFPDyLPCSVML
0	1		S212	KPLHLAVSLNKEIYF
0	1		N214	LHLAVSLNKEIYFHG
0	1		T227	HGEPIPVTVTVTNNT
0	1		T229	EPIPVTVTVTNNTEK
0	1		T231	IPVTVTVTNNTEKTV
0	1		T234	TVTVTNNTEKTVKKI
0	4		Y254-p	QVANVVLySSDyYVK
0	4		Y258-p	VVLySSDyYVKPVAM
0	1		Y331	VLGILVSYQIKVKLT
0	1		S348-p	GFLGELTssEVAtEV
0	1		S349-p	FLGELTssEVAtEVP
0	1		T353-p	LTssEVAtEVPFRLM

	mouse
K9	AACGKTNKsHVIFKK
S10-p	ACGKTNKsHVIFKKV
Y26	RDKSVTIYLGKRDYV
Y59	LVKGKKVYVTLTCAF
T61	KGKKVYVTLTCAFRY
T63	KKVYVTLTCAFRYGQ
Y117	KKLGDNTYPFLLTFP
Y126	FLLTFPDYLPCSVML
S209	KPLNLSVSLSKEIYF
S211	LNLSVSLSKEIYFHG
T224	HGEPIPVTVTVTNNT
T226	EPIPVTVTVTNNTDK
T228	IPVTVTVTNNTDKVV
T231	TVTVTNNTDKVVKKI
Y251	QIANVVLYSSDYYVK
Y255	VVLYSSDYYVKPVAS
Y328	VMGILVSYHIKVKLT
S345	GFLGELTSSEVATEV
S346	FLGELTSSEVATEVP
T350	LTSSEVATEVPFRLM

	rat
K9	AACVKTNKSHVIFKK
S10	ACVKTNKSHVIFKKV
Y26	RDKSVTIYLGKRDYI
Y59	LVKGKKVYVTLTCAF
T61	KGKKVYVTLTCAFRY
T63	KKVYVTLTCAFRYGQ
Y117	KKLGDNTYPFLLTFP
Y126	FLLTFPDYLPCSVML
S209-p	KPLHLSVsLsKEIYF
S211-p	LHLSVsLsKEIYFHG
T224-p	HGEPIPVtVtVtNNt
T226-p	EPIPVtVtVtNNtEK
T228-p	IPVtVtVtNNtEKVV
T231-p	tVtVtNNtEKVVKKI
Y251	QIANVVLYSSDYYVK
Y255	VVLYSSDYYVKPVAS
Y328-p	VMGILVSyHIKVKLT
S345	GFLGELTSSEVATEV
S346	FLGELTSSEVATEVP
T350	LTSSEVATEVPFRLM

	cow
K5	___MKANKPAPNHVI
P6	__MKANKPAPNHVIF
Y25	RDKSVTIYLGKRDYI
Y58	LVKGKRVYVSLTCAF
S60	KGKRVYVSLTCAFRY
T62	KRVYVSLTCAFRYGQ
Y116	KKLGANTYPFLLTFP
Y125	FLLTFPDYLPCSVML
S208	KPLRLAVSLSKEIYY
S210	LRLAVSLSKEIYYHG
T223	HGEPIPVTVAVTNST
A225	EPIPVTVAVTNSTEK
T227	IPVTVAVTNSTEKTV
T230	TVAVTNSTEKTVKKI
Y250	QVTNVVLYSSDYYIK
Y254	VVLYSSDYYIKTVAA
Y327	VMGILVSYQIKVKLT
S344	GLLGELTSSEVATEV
S345	LLGELTSSEVATEVP
T349	LTSSEVATEVPFRLM

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