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PPEF-1 (human)

Overview PPEF-1 a Ser/Thr phosphatase. Contains at least two EF-hand calcium-binding motifs in its C terminus. May play a role in specific sensory neuron function and/or development. Shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein phosphatase, Ser/Thr (non-receptor); Protein phosphatase, dual-specificity; EC 3.1.3.16; Motility/polarity/chemotaxis Molecular Function: protein binding; iron ion binding; manganese ion binding; calcium ion binding; protein serine/threonine phosphatase activity Biological Process: detection of stimulus involved in sensory perception; protein amino acid dephosphorylation Reference #:  O14829 (UniProtKB) Alt. Names/Synonyms: PP7; PPE1; PPEF; PPEF-1; PPEF1; PPP7C; PPP7CA; protein phosphatase 7, catalytic subunit, alpha isozyme; Protein phosphatase with EF calcium-binding domain; protein phosphatase, EF-hand calcium binding domain 1; protein phosphatase, serine/threonine type, with EF-hands; serine/threonine protein phosphatase 7; Serine/threonine-protein phosphatase 7; Serine/threonine-protein phosphatase with EF-hands 1 Gene Symbols: PPEF1 Molecular weight: 75,792 Da Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states

Select Structure to View Below PPEF-1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	10		S84-p	ELELRNQsLESEQDM
0	1		Y253-p	TKEILHKyKLHGKRI
0	1		T420-p	CHDGKVVtIFSASNY
0	1		Y437-p	EGSNRGAyIKLCSGT

	mouse
I84	DSALVTRIFDNTRRE
Y256	TKEILQKYKLHGRKI
T421	SHDGKVITVFSASNY
Y438	EGSNRGAYIRLSYGT

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