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DNAJB1 (human)

Overview DNAJB1 a chaperone protein that translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Interacts with DNAJC3. Interacts with SRPK1. Note: This description may include information from UniProtKB. Protein type: Chaperone Cellular Component: cytoplasm; nucleolus Molecular Function: heat shock protein binding; unfolded protein binding Biological Process: chaperone cofactor-dependent protein folding; response to unfolded protein Reference #:  P25685 (UniProtKB) Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily B, member 1; DnaJ (Hsp40) homolog, subfmaily B, member 1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; DNAJ1; DNAJB1; DNJB1; hDj-1; HDJ1; Heat shock 40 kDa protein 1; heat shock 40kD protein 1; Heat shock protein 40; HSP40; HSPF1; Human DnaJ protein 1; radial spoke 16 homolog B; RSPH16B; Sis1 Gene Symbols: DNAJB1 Molecular weight: 38,044 Da Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DNAJB1 1HDJ - A=1-76 (human) 2QLD - A=158-340 (human) 3AGX - A/B=161-340 (human) 3AGY - A/B=161-340 (human) 3AGZ - A/B=151-340 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HDJ 2QLD 3AGX 3AGY 3AGZ  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		Y5-p	___MGKDyYQTLGLA
0	2		K21-u	GASDEEIkRAYRRQA
0	3		K35-u	ALRYHPDkNKEPGAE
0	1		K44-a	KEPGAEEkFKEIAEA
0	1		K44	KEPGAEEKFKEIAEA
0	1		K46	PGAEEkFKEIAEAYD
0	1		T88-p	SGGGANGtsFSYTFH
0	1		S89-p	GGGANGtsFSYTFHG
0	1		S151-p	VNFGRSRsAQEPARK
0	519		Y176-p	RVSLEEIysGCtkKM
0	3		S177-p	VSLEEIysGCtkKMK
0	1		T180-p	EEIysGCtkKMKIsH
0	6		K181-a	EIysGCtkKMKIsHK
0	4		S186-p	CtkKMKIsHKRLNPD
0	9		K195-u	KRLNPDGksIRNEDK
0	2		K195-a	KRLNPDGksIRNEDK
0	1		S196-p	RLNPDGksIRNEDKI
0	1		T205-p	RNEDKILtIEVKKGW
0	1		T227-p	FPKEGDQtSNNIPAD
0	2		K286-u	RTIPVVFkDVIRPGM
0	1		K296-u	IRPGMRRkVPGEGLP
0	1		K306-u	GEGLPLPktPEKRGD
0	3		T307-p	EGLPLPktPEKRGDL

	mouse
Y5	___MGKDYYQTLGLA
K21	GASDDEIKRAYRRQA
K35-u	ALRYHPDkNKEPGAE
K44	KEPGAEEKFkEIAEA
K44-u	KEPGAEEkFkEIAEA
K46-u	PGAEEkFkEIAEAYD
T88	SSGGANGTSFSYTFH
S89	SGGANGTSFSYTFHG
P151	MNFGRSRPSQEPTRK
Y176-p	RVSLEEIySGCTKKM
S177	VSLEEIySGCTKKMK
T180	EEIySGCTKKMKISH
K181	EIySGCTKKMKISHK
S186	CTKKMKISHKRLNPD
K195-u	KRLNPDGkSIRNEDK
K195	KRLNPDGKSIRNEDK
S196	RLNPDGkSIRNEDKI
T205	RNEDKILTIEVKRGW
T227	FPKEGDQTSNNIPAD
K286-u	RTIPVVFkDVIRPGM
K296	IRPGMRRKVPGEGLP
K306	GEGLPLPKTPEKRGD
T307	EGLPLPKTPEKRGDL

	rat
Y5	___MGKDYYQTLGLA
K21	GASDDEIKRAYRRQA
K35	ALRYHPDKNKEPGAE
K44	KEPGAEEKFKEIAEA
K44	KEPGAEEKFKEIAEA
K46	PGAEEKFKEIAEAYD
T88	SSGGANGTSFSYTFH
S89	SGGANGTSFSYTFHG
P151	MNFGRSRPTQEPTRK
Y176-p	RVSLEEIySGCTKKM
S177	VSLEEIySGCTKKMK
T180	EEIySGCTKKMKISH
K181	EIySGCTKKMKISHK
S186	CTKKMKISHKRLNPD
K195	KRLNPDGKSIRNEDK
K195	KRLNPDGKSIRNEDK
S196	RLNPDGKSIRNEDKI
T205	RNEDKILTIEVKRGW
T227	FPKEGDQTSNNIPAD
-	gap
-	gap
-	gap
-	gap

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