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S100B (human)

Overview S100B Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family. Note: This description may include information from UniProtKB. Protein type: Calcium-binding protein Cellular Component: ruffle; cell soma; perinuclear region of cytoplasm; cytoplasm; extracellular region; nucleus Molecular Function: identical protein binding; RAGE receptor binding; protein binding; protein homodimerization activity; zinc ion binding; calcium ion binding; tau protein binding; calcium-dependent protein binding Biological Process: cell proliferation; central nervous system development; positive regulation of I-kappaB kinase/NF-kappaB cascade; learning and/or memory; axonogenesis; innate immune response; memory; regulation of neuronal synaptic plasticity Reference #:  P04271 (UniProtKB) Alt. Names/Synonyms: NEF; Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 beta; S100 calcium binding protein B; S100 calcium binding protein, beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); S100B; S100beta Gene Symbols: S100B Molecular weight: 10,713 Da Basal Isoelectric point: 4.57  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below S100B 1MQ1 - A/B=2-92 (human) 1UWO - A/B=1-92 (human) 2H61 - A/B/C/D/E/F/G/H=1-92 (human) 2PRU - A/B=2-92 (human) 3CZT - X=1-92 (human) 3D0Y - A/B=1-92 (human) 3D10 - A/B=1-92 (human) 3HCM - A/B=1-92 (human) 1B4C - A/B=1-92 (rat) 1DT7 - A/B=1-92 (rat) 1MWN - A/B=1-92 (rat) 1QLK - A/B=1-92 (rat) 1SYM - A/B=1-92 (rat) 1XYD - A/B=1-92 (rat) 2K7O - A/B=2-92 (rat) 1CFP - A/B=1-92 (cow) 1MHO - A=1-89 (cow) 1PSB - A/B=1-92 (cow) 3CR2 - A=1-92 (cow) 3CR4 - X=1-92 (cow) 3CR5 - X=1-92 (cow) 3GK1 - A=1-92 (cow) 3GK2 - A=1-92 (cow) 3GK4 - X=1-92 (cow) 3IQO - A/B=1-92 (cow) 3IQQ - A=1-92 (cow) 3LK0 - A/D/C/B=1-90 (cow) 3LK1 - A=1-90 (cow) 3LLE - A/B=1-92 (cow) 3RLZ - A/B=1-92 (cow) 3RM1 - A=1-92 (cow) 4FQO - A=1-89 (cow)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		N63	KVMETLDNDGDGECD

	mouse
E63	KVMETLDEDGDGECD

	rat
E63	KVMETLDEDGDGECD

	cow
S63-p	KVMETLDsDGDGECD

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