Home

PPP5C (human)

Overview PPP5C a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Cellular Component: Golgi apparatus; neuron projection; cell soma; cytoplasm; nucleus; cytosol Molecular Function: identical protein binding; protein binding; signal transducer activity; metal ion binding; protein serine/threonine phosphatase activity Biological Process: mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to morphine; signal transduction; protein amino acid dephosphorylation Reference #:  P53041 (UniProtKB) Alt. Names/Synonyms: FLJ36922; PP-T; PP5; PPP5; PPP5C; PPT; protein phosphatase 5, catalytic subunit; Protein phosphatase T; Serine/Threonine phosphatase; Serine/threonine-protein phosphatase 5 Gene Symbols: PPP5C Molecular weight: 56,879 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPP5C 1A17 - A=16-181 (human) 1S95 - A/B=169-499 (human) 1WAO - 1/2/3/4=23-499 (human) 2BUG - A=18-147 (human) 3H60 - A/B=176-490 (human) 3H61 - A/D=176-490 (human) 3H62 - C/B=176-490 (human) 3H63 - A/C=176-490 (human) 3H64 - A/D=176-490 (human) 3H66 - A/B=176-490 (human) 3H67 - A/D=176-490 (human) 3H68 - A/D=176-490 (human) 3H69 - A/D=176-490 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K32-u	LKRAEELkTQANDYF
0	1		K40-u	TQANDYFkAKDYENA
0	1		K49-u	KDYENAIkFYSQAIE
0	2		Y80-p	LRTECYGyALGDATR
0	3		S105-p	GYYRRAAsNMALGkF
0	1		K111-a	AsNMALGkFRAALRD
0	7		Y119-p	FRAALRDyEtVVKVK
0	1		T121-p	AALRDyEtVVKVKPH
0	2		K135-a	HDKDAKMkYQECNKI
0	2		Y176-p	SMTIEDEySGPKLED
0	1		K185-u	GPKLEDGkVTISFMK
0	1		S277-p	GDFVDRGsFsVEVIL
0	1		S279-p	FVDRGsFsVEVILtL
0	1		T285-p	FsVEVILtLFGFKLL
0	8		Y313-p	TDNMNQIyGFEGEVk
0	1		K320-u	yGFEGEVkAKYTAQM
0	1		S387-p	PMCDLLWsDPQPQNG
0	1		S403-p	SISKRGVsCQFGPDV
0	7		Y434-p	HEVKAEGyEVAHGGR

	mouse
K32	LKRAEELKTQANDYF
K40	TQANDYFKAKDYENA
K49	KDYENAIKFYSQAIE
Y80	LRTECYGYALGDATR
S105	GYYRRAASNMALGKF
K111	ASNMALGKFRAALRD
Y119	FRAALRDYETVVKVK
T121	AALRDYETVVKVKPN
K135	NDKDAKMKYQECSKI
Y176	SMTIEDEYSGPKLED
K185	GPKLEDGKVTITFMK
S277	GDFVDRGSFSVEVIL
S279	FVDRGSFSVEVILTL
T285	FSVEVILTLFGFKLL
Y313	TDNMNQIYGFEGEVK
K320	YGFEGEVKAKYTAQM
S387	PMCDLLWSDPQPQNG
S403	SVSKRGVSCQFGPDV
Y434	HEVKAEGYEVAHGGR

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.