a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Protein phosphatase, Ser/Thr (non-receptor)
Molecular Function: identical protein binding; signal transducer activity; protein binding; RNA binding; heat shock protein binding; metal ion binding; microtubule binding; G-protein alpha-subunit binding; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; lipid binding
Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; mitosis; histone dephosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein heterooligomerization; MAPKKK cascade; response to morphine; DNA repair; protein amino acid dephosphorylation; negative regulation of protein amino acid phosphorylation; small GTPase mediated signal transduction; Ras protein signal transduction; response to lead ion; insulin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.