a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Protein phosphatase, Ser/Thr (non-receptor)
Molecular Function: identical protein binding; protein binding; signal transducer activity; RNA binding; metal ion binding; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; lipid binding
Biological Process: cell death; mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein heterooligomerization; response to morphine; signal transduction; protein amino acid dephosphorylation; DNA repair
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.