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Protein Page:
PPP5C (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PPP5C a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)
Cellular Component: neuron projection; cell soma; membrane; cytosol
Molecular Function: identical protein binding; protein binding; signal transducer activity; RNA binding; metal ion binding; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; lipid binding
Biological Process: cell death; mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein heterooligomerization; response to morphine; signal transduction; protein amino acid dephosphorylation; DNA repair
Reference #:  P53041 (UniProtKB)
Alt. Names/Synonyms: FLJ36922; PP-T; PP5; PPP5; PPP5C; PPT; protein phosphatase 5, catalytic subunit; Protein phosphatase T; Serine/Threonine phosphatase; Serine/threonine-protein phosphatase 5
Gene Symbols: PPP5C
Molecular weight: 56,879 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP5C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K32-u LKRAEELkTQANDYF
0 1 K40-u TQANDYFkAKDYENA
0 1 K49-u KDYENAIkFYSQAIE
0 2 Y80-p LRTECYGyALGDATR
0 3 S105-p GYYRRAAsNMALGKF
0 7 Y119-p FRAALRDyETVVKVK
0 2 K135-a HDKDAKMkYQECNKI
0 2 Y176-p SMTIEDEySGPKLED
0 1 K185-u GPKLEDGkVTISFMK
0 8 Y313-p TDNMNQIyGFEGEVk
0 1 K320-u yGFEGEVkAKYTAQM
0 7 Y434-p HEVKAEGyEVAHGGR
  mouse

 
K32 LKRAEELKTQANDYF
K40 TQANDYFKAKDYENA
K49 KDYENAIKFYSQAIE
Y80 LRTECYGYALGDATR
S105 GYYRRAASNMALGKF
Y119 FRAALRDYETVVKVK
K135 NDKDAKMKYQECSKI
Y176 SMTIEDEYSGPKLED
K185 GPKLEDGKVTITFMK
Y313 TDNMNQIYGFEGEVK
K320 YGFEGEVKAKYTAQM
Y434 HEVKAEGYEVAHGGR
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