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Protein Page:
ABCC8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ABCC8 a multi-pass membrane protein subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Associates with Kir6.2. Defects in ABCC8 are a cause of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) [MIM:601820, 256450], and may contribute to non-insulin-dependent diabetes mellitus (NIDDM) in Northern European Caucasians. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family
Cellular Component: voltage-gated potassium channel complex; plasma membrane
Molecular Function: sulfonylurea receptor activity; ATPase activity, coupled to transmembrane movement of substances; potassium ion transmembrane transporter activity; ATP binding
Biological Process: ATP catabolic process; synaptic transmission; carbohydrate metabolic process; energy reserve metabolic process; signal transduction; transmembrane transport; regulation of insulin secretion; potassium ion transport
Reference #:  Q09428 (UniProtKB)
Alt. Names/Synonyms: ABC36; ABCC8; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HHF1; HI; HRINS; MRP8; PHHI; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; SUR; SUR1; TNDM2
Gene Symbols: ABCC8
Molecular weight: 176,992 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
Select Structure to View Below

ABCC8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S720-p GQVGCGKsSLLLAAL
0 1 Y798-p SPFNKQRyKMVIEAC
0 1 K889-ub TVVLVTHkLQYLPHA
0 1 K903-ub ADWIIAMkDGTIQRE
0 1 K947 KETVTERKAtEPPQG
0 1 T949-p TVTERKAtEPPQGLS
0 3 S979 EEEEAAESEEDDNLS
0 1 S986 SEEDDNLSSMLHQRA
0 1 S1324-p LLKTEAEsYEGLLAP
0 1 Y1353-p IQNLSVRyDssLKPV
0 1 S1355-p NLSVRyDssLKPVLK
0 1 S1356-p LSVRyDssLKPVLKH
0 1 K1358 VRyDssLKPVLKHVN
1 0 S1446 LDPERKCSDSTLWEA
0 1 K1569 PEKLLSRKDSVFASF
0 1 K1581 ASFVRADK_______
  ABCC8 iso2  
S720 GQVGCGKSSLLLAAL
Y799 SPFNKQRYKMVIEAC
K890 TVVLVTHKLQYLPHA
K904 ADWIIAMKDGTIQRE
K948 KETVTERKATEPPQG
T950 TVTERKATEPPQGLS
S980 EEEEAAESEEDDNLS
S987 SEEDDNLSSMLHQRA
S1325 LLKTEAESYEGLLAP
Y1354 IQNLSVRYDSSLKPV
S1356 NLSVRYDSSLKPVLK
S1357 LSVRYDSSLKPVLKH
K1359 VRYDSSLKPVLKHVN
S1447 LDPERKCSDSTLWEA
K1570 PEKLLSRKDSVFASF
K1582 ASFVRADK_______
  mouse

 
S720 GQVGCGKSSLLLATL
Y805 SPFNKQRYKMVIEAC
K896 TVVLVTHKLQYLPHA
K910 ADWIIAMKDGTIQRE
K954-ub KETVMERkAPEPSQG
P956 TVMERkAPEPSQGLP
S986-p EEEEAAEsEEDDNLs
S993-p sEEDDNLsSVLHQRA
S1331 LLKTEAESYEGLLAP
Y1360 IQNLSVRYDSSLkPV
S1362 NLSVRYDSSLkPVLK
S1363 LSVRYDSSLkPVLKH
K1365-ub VRYDSSLkPVLKHVN
S1453 LDPEKKCSDSTLWEA
K1576-ub PEKLLSQkDSVFASF
K1588-ac ASFVRADk_______
  hamster

 
S720 GQVGCGKSSLLLATL
Y799 SPFNKQRYKMVIEAC
K890 TVVLVTHKLQYLPHA
K904 ADWIIAMKDGTIQRE
K948 KETVMERKASEPSQG
S950 TVMERKASEPSQGLP
S980 EEEEAAESEEDDNLS
S987 SEEDDNLSSVLHQRA
S1325 LLKTEAESYEGLLAP
Y1354 IQNLSVRYDSSLKPV
S1356 NLSVRYDSSLKPVLK
S1357 LSVRYDSSLKPVLKH
K1359 VRYDSSLKPVLKHVN
S1447-p LDPEKKCsDSTLWEA
K1570 PETLLSQKDSVFASF
K1582 ASFVRADK_______
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