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Protein Page:
ABCC8 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ABCC8 a multi-pass membrane protein subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Associates with Kir6.2. Defects in ABCC8 are a cause of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) [MIM:601820, 256450], and may contribute to non-insulin-dependent diabetes mellitus (NIDDM) in Northern European Caucasians. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: voltage-gated potassium channel complex; plasma membrane
Molecular Function: sulfonylurea receptor activity; ATPase activity, coupled to transmembrane movement of substances; potassium ion transmembrane transporter activity; ATP binding
Biological Process: synaptic transmission; carbohydrate metabolic process; energy reserve metabolic process; signal transduction; regulation of insulin secretion; transmembrane transport; potassium ion transport
Reference #:  Q09428 (UniProtKB)
Alt. Names/Synonyms: ABC36; ABCC8; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HHF1; HI; HRINS; MRP8; PHHI; sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; SUR; SUR1; TNDM2
Gene Symbols: ABCC8
Molecular weight: 176,992 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
Select Structure to View Below

ABCC8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K947 KETVTERKATEPPQG
0 3 S979 EEEEAAESEEDDNLS
0 1 S986 SEEDDNLSSMLHQRA
0 1 K1358 VRYDSSLKPVLKHVN
1 0 S1446 LDPERKCSDSTLWEA
0 1 K1569 PEKLLSRKDSVFASF
  ABCC8 iso2  
K948 KETVTERKATEPPQG
S980 EEEEAAESEEDDNLS
S987 SEEDDNLSSMLHQRA
K1359 VRYDSSLKPVLKHVN
S1447 LDPERKCSDSTLWEA
K1570 PEKLLSRKDSVFASF
  mouse

 
K954-u KETVMERkAPEPSQG
S986-p EEEEAAEsEEDDNLs
S993-p sEEDDNLsSVLHQRA
K1365-u VRYDSSLkPVLKHVN
S1453 LDPEKKCSDSTLWEA
K1576-u PEKLLSQkDSVFASF
  hamster

 
K948 KETVMERKASEPSQG
S980 EEEEAAESEEDDNLS
S987 SEEDDNLSSVLHQRA
K1359 VRYDSSLKPVLKHVN
S1447-p LDPEKKCsDSTLWEA
K1570 PETLLSQKDSVFASF
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