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Protein Page:
UPF2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UPF2 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; RNA binding
Biological Process: mRNA export from nucleus; organ regeneration; RNA metabolic process; mRNA catabolic process, nonsense-mediated decay; gene expression; liver development; mRNA metabolic process
Reference #:  Q9HAU5 (UniProtKB)
Alt. Names/Synonyms: DKFZp434D222; hUpf2; KIAA1408; MGC138834; MGC138835; Nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; RENT2; smg-3; Up-frameshift suppressor 2 homolog; UPF2; UPF2 regulator of nonsense transcripts homolog; UPF2 regulator of nonsense transcripts homolog (yeast); yeast Upf2p homolog
Gene Symbols: UPF2
Molecular weight: 147,810 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UPF2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K58-m3 KAPEDKKkRLEDDKR
0 1 K67 LEDDKRKKEDKERKK
0 1 K75-ac EDKERKKkDEEkVKA
0 1 K79-ac RKKkDEEkVKAEEES
0 1 K103-ub KHQEEERkKQEEQAK
0 1 K176 KKNTAFVKKLKTITE
0 1 Y233-p CSLFHQRyADFAPsL
0 1 S239-p RyADFAPsLLQVWKK
0 1 S285-p FTDKEGLsLIyEQLK
0 1 Y288-p KEGLsLIyEQLKNII
0 1 S345-p FPPSEIIsPEKQQPF
0 1 Y359-p FQNLLKEyFTSLTKH
0 1 S513-p SKENKEVsSPDDLEL
0 1 T597-p DFCMNMNtKANRKKL
0 1 Y744-p AMHLDARyVtMVENA
0 1 T746-p HLDARyVtMVENAYY
0 1 K941-ac DRGSSKRkLDCFLVY
0 1 K964-ac KSLEVWTkDHPFPID
0 1 Y974-p PFPIDIDyMISDTLE
0 5 T1088-p DSNKENEtDEENTEV
0 8 Y1228-p ERQEQEDyQEMLQsL
0 1 S1234-p DyQEMLQsLAQRPAP
0 1 T1244-p QRPAPANtNRERRPR
  mouse

 
K58 KVPEDKKKRLEEDKR
K67-ac LEEDKRKkEDKERKK
K75 EDKERKKKEEEKVKA
K79 RKKKEEEKVKAEEEL
K103 KQEEEERKKQEEQAK
K175-ac KKNTAFVkKLKTITE
Y232 CSLFHQRYSDFAPSL
S238 RYSDFAPSLLQVWKK
S284 FTDKEGLSLIYEQLK
Y287 KEGLSLIYEQLKSII
S344 FPPSEIISPEKQQPF
Y358 FQNLLKEYFTSLTKH
S511 PKDNKEASSPDDLEL
T595 DFCMNMNTKANRKKL
Y742 AMHLDARYVTMVENA
T744 HLDARYVTMVENAYY
K939 DRGSSKRKLDCFLVY
K962 KSLEVWTKDHPFPID
Y972 PFPIDIDYMISDTLE
T1085 DSNKENETDEENAEV
Y1225 ERQEQEDYQEMLQSL
S1231 DYQEMLQSLAQRPAP
T1241 QRPAPANTNRERRPR
  rat

 
K58 KVPEDKKKKLEEDKR
K67 LEEDKRKKEDKERKK
K75 EDKERKKKEEEKVKA
K79 RKKKEEEKVKAEEEL
K103 KQEEEERKKQEEQAK
K175 KKNTAFVKKLKTITE
Y232 CSLFHQRYADFAPSL
S238 RYADFAPSLLQVWKK
S284 FTDKEGLSLIYEQLK
Y287 KEGLSLIYEQLKSII
S344 FPPSEIISPEKQQPF
Y358 FQNLLKEYFTSLTKH
S511 PKDNKEASSPDDLEL
T595 DFCMNMNTKANRKKL
Y742 AMHLDARYVTMVENA
T744 HLDARYVTMVENAYY
K939 DRGSSKRKLDCFLVY
K962 KSLEVWTKDHPFPID
Y972 PFPIDIDYMISDTLE
T1085 DSNKENETDEENAEV
Y1224 ERQEQEDYQEMLQSL
S1230 DYQEMLQSLAQRPAP
T1240 QRPAPANTNRERRPR
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