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UPF2
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: RNA binding protein |
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Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
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Molecular Function: protein binding; DNA binding; RNA binding
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Biological Process: mRNA export from nucleus; organ regeneration; RNA metabolic process; mRNA catabolic process, nonsense-mediated decay; gene expression; liver development; mRNA metabolic process
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Reference #:
Q9HAU5 (UniProtKB)
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| Alt. Names/Synonyms: DKFZp434D222; hUpf2; KIAA1408; MGC138834; MGC138835; Nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; RENT2; smg-3; Up-frameshift suppressor 2 homolog; UPF2; UPF2 regulator of nonsense transcripts homolog; UPF2 regulator of nonsense transcripts homolog (yeast); yeast Upf2p homolog |
| Gene Symbols: UPF2 |
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Molecular weight: 147,810 Da
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Basal Isoelectric point: 5.5
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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