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Protein Page:
PSME2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSME2 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexadimeric ring. By IFNG/IFN-gamma. Belongs to the PA28 family. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex; Protease
Cellular Component: proteasome complex; nucleoplasm; proteasome activator complex; cytosol
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  Q9UL46 (UniProtKB)
Alt. Names/Synonyms: 11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; cell migration-inducing protein 22; MCP activator, 31-kD subunit; PA28b; PA28beta; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); Proteasome activator 28 subunit beta; proteasome activator 28-beta; Proteasome activator complex subunit 2; proteasome activator hPA28 subunit beta; PSME2; REG-beta; REGbeta
Gene Symbols: PSME2
Molecular weight: 27,402 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSME2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3-m2 _____MAkPCGVRLs
0 4 S10-p kPCGVRLsGEARkQV
0 2 K15-ub RLsGEARkQVEVFRQ
0 1 K15 RLsGEARKQVEVFRQ
0 9 K39-ub LYRFLPQkIIYLNQL
0 3 K108-ub LSLLALVkPEVWTLk
0 1 K115-ub kPEVWTLkEKCILVI
0 63 K145-ub FGVAIQEkVLERVNA
0 2 K180-ac DAVAKASkETHVMDY
0 11 Y199-p HERDEAAyGELRAMV
0 1 K231-sc LEKIVNPkGEEKPSM
0 131 Y239-p GEEKPSMy_______
  mouse

 
K3 _____MAKPCGVRLs
S10-p KPCGVRLsGEARkQV
K15-ub RLsGEARkQVDVFRQ
K15-ac RLsGEARkQVDVFRQ
K39 LCTFLPRKIISLSQL
K108 LALLALVKPEVWTLK
K115 KPEVWTLKEKCILVI
K145-ub FGVAIQEkVLERVNA
K180-ac DAVAKASkDTHVMDY
Y199 HERDEAAYGALRAMV
K231 LEKIVNPKGEEKPSM
Y239-p GEEKPSMy_______
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