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PSME2 (human)

Overview PSME2 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexadimeric ring. By IFNG/IFN-gamma. Belongs to the PA28 family. Note: This description may include information from UniProtKB. Protein type: Proteasome complex; Protease Cellular Component: nucleoplasm; proteasome complex; proteasome activator complex; cytosol Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; M/G1 transition of mitotic cell cycle; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; S phase of mitotic cell cycle; regulation of amino acid metabolic process; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  Q9UL46 (UniProtKB) Alt. Names/Synonyms: 11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; cell migration-inducing protein 22; MCP activator, 31-kD subunit; PA28b; PA28beta; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); Proteasome activator 28 subunit beta; proteasome activator 28-beta; Proteasome activator complex subunit 2; proteasome activator hPA28 subunit beta; PSME2; REG-beta; REGbeta Gene Symbols: PSME2 Molecular weight: 27,402 Da Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PSME2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3-m2	_____MAkPCGVRLs
0	2		S10-p	kPCGVRLsGEARkQV
0	2		K15-u	RLsGEARkQVEVFRQ
0	1		K15	RLsGEARKQVEVFRQ
0	9		K39-u	LYRFLPQkIIYLNQL
0	3		K108-u	LSLLALVkPEVWTLk
0	1		K115-u	kPEVWTLkEKCILVI
0	63		K145-u	FGVAIQEkVLERVNA
0	1		K180-a	DAVAKASkETHVMDY
0	11		Y199-p	HERDEAAyGELRAMV
0	136		Y239-p	GEEKPSMy_______

	mouse
K3	_____MAKPCGVRLs
S10-p	KPCGVRLsGEARkQV
K15-u	RLsGEARkQVDVFRQ
K15-a	RLsGEARkQVDVFRQ
K39	LCTFLPRKIISLSQL
K108	LALLALVKPEVWTLK
K115	KPEVWTLKEKCILVI
K145-u	FGVAIQEkVLERVNA
K180	DAVAKASKDTHVMDY
Y199	HERDEAAYGALRAMV
Y239-p	GEEKPSMy_______

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