Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ACAT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ACAT2 The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]
Protein type: Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - lysine degradation; EC 2.3.1.9; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - butanoate; Acetyltransferase; Lipid Metabolism - fatty acid
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: acetyl-CoA C-acetyltransferase activity
Biological Process: lipid metabolic process
Reference #:  Q9BWD1 (UniProtKB)
Alt. Names/Synonyms: ACAT2; acetoacetyl Coenzyme A thiolase; Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA transferase-like protein; acetyl-Coenzyme A acetyltransferase 2; ACTL; Cytosolic acetoacetyl-CoA thiolase; THIC
Gene Symbols: ACAT2
Molecular weight: 41,351 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACAT2

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5 ___MNAGSDPVVIVS
0 1 S12 SDPVVIVSAARTIIG
0 2 Y81-p SVGAGIPySVPAWSC
0 2 Y130-p SKAPHLAyLRTGVKI
0 2 K200-ac QKAGHFDkEIVPVLV
0 2 K233-ac SNIEAMSkLkPYFLT
0 3 K235-ac IEAMSkLkPYFLTDG
0 2 K235-ub IEAMSkLkPYFLTDG
0 1 K265 AAAVVLMKKSEADKR
  mouse

 
S5-p ___MNAGsDPVVIVs
S12-p sDPVVIVsAARTAIG
Y81 SVGAGIPYSVPAWSC
H130 SKAPHLTHLRTGVRM
K200-ac QKAGHFDkEIVPVLV
K233-ac SNLEAMGkLkPYFLT
K235-ac LEAMGkLkPYFLTDG
K235-ub LEAMGkLkPYFLTDG
K265-ub AAAVVLMkKTEAERR
  rat

 
S5 ___MNAGSDPVVIIS
S12 SDPVVIISAARTAIG
Y81 SVGAGIPYSVPAWSC
H130 SKAPHLAHLRSGVKM
K200 QKAGHFDKEIVPVHV
K233 SNLEAMSKLKPYFLT
K235 LEAMSKLKPYFLTDG
K235 LEAMSKLKPYFLTDG
K265 AAAVVLMKKTEAESR
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.