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Casp10 (human)

Overview Casp10 Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.4.22.63; EC 3.4.22.-; Protease Cellular Component: plasma membrane; cytosol Molecular Function: protein binding; cysteine-type endopeptidase activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; induction of apoptosis; innate immune response; proteolysis Reference #:  Q92851 (UniProtKB) Alt. Names/Synonyms: ALPS2; Apoptotic protease Mch-4; CASP-10; CASP10; CASPA; caspase 10, apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine protease; Caspase-10; Caspase-10 subunit p12; Caspase-10 subunit p23/17; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; MCH4 Gene Symbols: CASP10 Molecular weight: 58,951 Da Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Casp10

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME 3.4.22.- 3.4.22.63  |  DISEASE 137215 601762 603909 605027  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	17		Y9-p	KSQGQHWySSSDKNC
0	1		K99-u	LQHLNCTkEEVERLL
0	1		K158-u	SFLAFLEkQGKIDED
0	2		T198-p	EKAIQIVtPPVDKEA
0	1		S216-p	QGEEELVsQTDVKTF
0	1		S260-p	SRGMQGAsANTLNSE
0	1		K271-u	LNSETSTkRAAVYRM
0	1		K338-u	EMEMVLQkQKCNPAH

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