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MKP-7 (human)

Overview MKP-7 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48 Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasm; nucleus Molecular Function: protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity Biological Process: MAPK export from nucleus; dephosphorylation; MAPK phosphatase export from nucleus, leptomycin B sensitive; protein amino acid dephosphorylation; inactivation of MAPK activity Reference #:  Q9BY84 (UniProtKB) Alt. Names/Synonyms: dual specificity phosphatase 16; Dual specificity protein phosphatase 16; DUS16; DUSP16; KIAA1700; MAP kinase phosphatase 7; MAPK phosphatase-7; MGC129701; MGC129702; Mitogen-activated protein kinase phosphatase 7; MKP-7; MKP7 Gene Symbols: DUSP16 Molecular weight: 73,102 Da Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states CST Pathways:  SAPK/JNK Signaling Cascades Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKP-7 2VSW - A/B=5-150 (human) 3TG3 - A/D/C/B=5-138 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2VSW 3TG3  |  ENZYME 3.1.3.16 3.1.3.48  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
protein stabilization: S446‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S82-p	HKVDIDCsQKVVVYD
0	2		S401-p	NKLKRSFsLDIKSVS
2	0		S446-p	TNKLCQFsPVQELSE
0	1		T455	VQELSEQTPETSPDK
0	1		S459	SEQTPETSPDKEEAS
0	1		S486	SQSKRLHSVRTSSSG
0	2		S501-p	TAQRSLLsPLHRSGS
0	1		S508	sPLHRSGSVEDNYHT
0	1		S604-p	VRRRQKPsDRADsRR
0	1		S609-p	KPsDRADsRRsWHEE
0	8		S612-p	DRADsRRsWHEESPF

	mouse
N82	HKVDIDCNQKVVVYD
S397-p	TKLKRSFsLDIKSVS
S441	TNKLCQFSPVQEVSE
S450-p	VQEVSEQsPETsPDK
S454-p	SEQsPETsPDKEEAH
S481-p	SQVTRLHsVRTGSSG
S496-p	STQRPFFsPLHRSGs
S503-p	sPLHRSGsVEDNYHT
T599	VRRRQKPTDRADSRR
S604	KPTDRADSRRsWHEE
S607-p	DRADSRRsWHEESPF

	rat
S82	HKVDIDCSQKVVVYD
S397	NRLKRSFSLDIKSVS
S441	TSKLCQFSPVQEVSE
T450	VQEVSEQTPETSPDK
S454	SEQTPETSPDKEEAH
S481	SQTTRLHSVRTSSTG
S496	STQRPFFSPLHRSGS
S503	SPLHRSGSVEDNYHT
S600	VRRRQKPSDRADSRR
S605	KPSDRADSRRSWHEE
S608	DRADSRRSWHEESPF

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