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Protein Page:
MKP-7 (human)

Overview
MKP-7 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasm; nucleolus; nucleus
Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity
Biological Process: MAPK export from nucleus; dephosphorylation; MAPK phosphatase export from nucleus, leptomycin B sensitive; protein amino acid dephosphorylation; inactivation of MAPK activity
Reference #:  Q9BY84 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 16; Dual specificity protein phosphatase 16; DUS16; DUSP16; KIAA1700; MAP kinase phosphatase 7; MAPK phosphatase-7; MGC129701; MGC129702; Mitogen-activated protein kinase phosphatase 7; MKP-7; MKP7
Gene Symbols: DUSP16
Molecular weight: 73,102 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKP-7

Protein Structure Not Found.


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Sites Implicated In
protein stabilization: S446‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S82-p HKVDIDCsQKVVVYD
0 1 P336 GGQKSETPLSPPCAD
0 5 S401-p NKLKRSFsLDIKSVS
2 1 S446-p TNKLCQFsPVQELSE
0 1 T455 VQELSEQTPETSPDK
0 1 S459 SEQTPETSPDKEEAS
0 1 S486 SQSKRLHSVRTSSSG
0 3 S501-p TAQRSLLsPLHRSGS
0 2 S508 sPLHRSGSVEDNYHT
0 1 S604-p VRRRQKPsDRADsRR
0 1 S609-p KPsDRADsRRsWHEE
0 10 S612-p DRADsRRsWHEESPF
0 1 S627-p EKQFKRRsCQMEFGE
  mouse

 
N82 HKVDIDCNQKVVVYD
S336-p GGWKSALsLSPPCAN
S397-p TKLKRSFsLDIKSVS
S441 TNKLCQFSPVQEVSE
S450-p VQEVSEQsPETsPDK
S454-p SEQsPETsPDKEEAH
S481-p SQVTRLHsVRTGSSG
S496-p STQRPFFsPLHRSGs
S503-p sPLHRSGsVEDNYHT
T599 VRRRQKPTDRADSRR
S604 KPTDRADSRRsWHEE
S607-p DRADSRRsWHEESPF
S622 EKQFKRRSCQMEFGE
  rat

 
S82 HKVDIDCSQKVVVYD
S336 GGRKNALSLSPPCAN
S397-p NRLKRSFsLDIKSVS
S441 TSKLCQFSPVQEVSE
T450 VQEVSEQTPETSPDK
S454 SEQTPETSPDKEEAH
S481 SQTTRLHSVRTSSTG
S496 STQRPFFSPLHRSGS
S503 SPLHRSGSVEDNYHT
S600 VRRRQKPSDRADSRR
S605 KPSDRADSRRsWHEE
S608-p DRADSRRsWHEESPF
S623 EKQFKRRSCQMEFGE
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