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Protein Page:
MKP-5 (human)

Overview
MKP-5 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity
Cellular Component: Golgi apparatus; cytoplasm; nucleolus; nucleus
Molecular Function: MAP kinase phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity
Biological Process: negative regulation of JNK cascade; negative regulation of JNK activity; regulation of adaptive immune response; JNK cascade; response to stress; response to lipopolysaccharide; protein amino acid dephosphorylation; inactivation of MAPK activity
Reference #:  Q9Y6W6 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 10; dual specificity phosphatase MKP-5; Dual specificity protein phosphatase 10; DUS10; DUSP10; MAP kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; MKP-5; MKP5; serine/threonine specific protein phosphatase
Gene Symbols: DUSP10
Molecular weight: 52,642 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKP-5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MPPsPLDDRVV
0 1 S70 SSSGSARSLNCGCSS
0 1 Y236-p FSKEIIVyDENtNEP
0 1 T240-p IIVyDENtNEPSRVM
  mouse

 
S4 ____MPPSPLDDRVV
S70-p SSSGSARsLNCGCSS
Y237 FSKEIIVYDENTNEP
T241 IIVYDENTNEPSRVT
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