a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 126.96.36.199; EC 188.8.131.52
Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; regulation of adaptive immune response; response to stress; JNK cascade; response to lipopolysaccharide; protein amino acid dephosphorylation; inactivation of MAPK activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.