Home

MKP-5 (human)

Overview MKP-5 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity Cellular Component: Golgi apparatus; cytoplasm; nucleolus; nucleus Molecular Function: MAP kinase phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity Biological Process: negative regulation of JNK cascade; negative regulation of JNK activity; regulation of adaptive immune response; JNK cascade; response to stress; response to lipopolysaccharide; protein amino acid dephosphorylation; negative regulation of stress-activated MAPK cascade; inactivation of MAPK activity Reference #:  Q9Y6W6 (UniProtKB) Alt. Names/Synonyms: dual specificity phosphatase 10; dual specificity phosphatase MKP-5; Dual specificity protein phosphatase 10; DUS10; DUSP10; MAP kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; MKP-5; MKP5; serine/threonine specific protein phosphatase Gene Symbols: DUSP10 Molecular weight: 52,642 Da Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states CST Pathways:  SAPK/JNK Signaling Cascades Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKP-5 1ZZW - A/B=320-467 (human) 2OUC - A/B=148-287 (human) 2OUD - A=315-482 (human) 3TG1 - B=139-288 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ZZW 2OUC 2OUD 3TG1  |  ENZYME 3.1.3.16 3.1.3.48  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S4-p	____MPPsPLDDRVV
0	1		S70	SSSGSARSLNCGCSS
0	1		Y236-p	FSKEIIVyDENtNEP
0	1		T240-p	IIVyDENtNEPSRVM

	mouse
S4	____MPPSPLDDRVV
S70-p	SSSGSARsLNCGCSS
Y237	FSKEIIVYDENTNEP
T241	IIVYDENTNEPSRVT

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.