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Protein Page:
AIM2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AIM2 a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; double-stranded DNA binding
Biological Process: apoptosis; positive regulation of interleukin-1 beta secretion; activation of NF-kappaB transcription factor; positive regulation of protein oligomerization; positive regulation of interleukin-1 beta production; tumor necrosis factor-mediated signaling pathway; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; immune response; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response
Reference #:  O14862 (UniProtKB)
Alt. Names/Synonyms: Absent in melanoma 2; AIM2; Interferon-inducible protein AIM2; PYHIN4
Gene Symbols: AIM2
Molecular weight: 38,954 Da
Basal Isoelectric point: 9.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AIM2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K39-ub EFNIATGkLHTANRI
0 1 K64-m2 GAVSAVMkTIRIFQk
0 1 K71-ac kTIRIFQkLNYMLLA
0 1 K79-ac LNYMLLAkRLQEEkE
0 1 K85-ac AkRLQEEkEKVDKQY
0 1 K160-ac CLPVMVLkAKKPFTF
0 1 K235-ub LDAESDQkVNVPLNI
0 1 T254-p GETPKINtLQtQPLG
0 1 T257-p PKINtLQtQPLGtIV
0 1 T262-p LQtQPLGtIVNGLFV
0 1 S332-p QLTSGVHsTIKVIKA
  mouse

 
T39 EFQIARSTLDVADRT
K64 GAASAVTKAINIFQK
K71 KAINIFQKLNYMHIA
N79 LNYMHIANALEEKKK
K85 ANALEEKKKEAERKL
K166 PLVVTVLKAINPFEC
- gap
K258 RETPRISKLKIQPCG
I261 PRISKLKIQPCGTIV
T266 LKIQPCGTIVNGLFK
S336 QLKSGPCSFFKVIKA
  rat

 
T39 EFNIPRKTLNIADRT
K64 GAASAVAKAISIFQK
K71 KAISIFQKLNYMDIA
K79 LNYMDIAKALEEKKK
K85 AKALEEKKKEAESKY
K166 SLVVMVLKAMNPFEC
K241 VDVESSHKVCVPNNI
K260 GETPKISKLKTLPCG
T263 PKISKLKTLPCGTIV
T268 LKTLPCGTIVNGLFK
S338 QLKSGPCSIYKVIKA
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