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AIM2 (human)

Overview AIM2 a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. Note: This description may include information from UniProtKB. Protein type: Tumor suppressor Cellular Component: mitochondrion; cytoplasm; nucleolus; cytoplasmic part; nucleus; cytosol Molecular Function: identical protein binding; protein binding; double-stranded DNA binding Biological Process: apoptosis; positive regulation of interleukin-1 beta secretion; activation of NF-kappaB transcription factor; positive regulation of protein oligomerization; positive regulation of interleukin-1 beta production; tumor necrosis factor-mediated signaling pathway; inhibition of NF-kappaB transcription factor; innate immune response; immune response; interleukin-1 beta secretion; positive regulation of defense response to virus by host; inflammatory response; activation of innate immune response Reference #:  O14862 (UniProtKB) Alt. Names/Synonyms: Absent in melanoma 2; AIM2; Interferon-inducible protein AIM2; PYHIN4 Gene Symbols: AIM2 Molecular weight: 38,954 Da Basal Isoelectric point: 9.79  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AIM2 3RN2 - A/B=144-343 (human) 3RN5 - A/D/C/B=144-343 (human) 3VD8 - A=1-107 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3RN2 3RN5 3VD8  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K39-u	EFNIATGkLHTANRI
0	1		K64-m2	GAVSAVMkTIRIFQk
0	1		K71-a	kTIRIFQkLNYMLLA
0	1		K79-a	LNYMLLAkRLQEEkE
0	1		K85-a	AkRLQEEkEKVDKQY
0	1		K160-a	CLPVMVLkAKKPFTF
0	1		K235-u	LDAESDQkVNVPLNI
0	1		T254-p	GETPKINtLQtQPLG
0	1		T257-p	PKINtLQtQPLGtIV
0	1		T262-p	LQtQPLGtIVNGLFV

	mouse
T39	EFQIARSTLDVADRT
K64	GAASAVTKAINIFQK
K71	KAINIFQKLNYMHIA
N79	LNYMHIANALEEKKK
K85	ANALEEKKKEAERKL
K166	PLVVTVLKAINPFEC
-	gap
K258	RETPRISKLKIQPCG
I261	PRISKLKIQPCGTIV
T266	LKIQPCGTIVNGLFK

	rat
T39	EFNIPRKTLNIADRT
K64	GAASAVAKAISIFQK
K71	KAISIFQKLNYMDIA
K79	LNYMDIAKALEEKKK
K85	AKALEEKKKEAESKY
K166	SLVVMVLKAMNPFEC
K241	VDVESSHKVCVPNNI
K260	GETPKISKLKTLPCG
T263	PKISKLKTLPCGTIV
T268	LKTLPCGTIVNGLFK

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