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Protein Page:
MTSS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MTSS1 an intracellular protein that binds to actin and cortactin, and possesses tumor suppressor activity. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. Senses and induces curved membranous curvatures important for cellular polarization, mobilization and endocytosis. May be related to cancer progression or tumor metastasis in a variety of organ sites. Its expression is down-regulated by MiR-135a. Downregulated in prostate cancer. Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. Belongs to the MTSS1 family. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: ruffle; endocytic vesicle; cytoplasm; actin cytoskeleton
Molecular Function: actin monomer binding; identical protein binding; protein binding; cytoskeletal adaptor activity; SH3 domain binding; receptor binding
Biological Process: filopodium formation; actin filament polymerization; microspike biogenesis; cell adhesion; actin cytoskeleton organization and biogenesis; cell motility; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of epithelial cell proliferation
Reference #:  O43312 (UniProtKB)
Alt. Names/Synonyms: DKFZp781P2223; FLJ44694; KIAA0429; metastasis suppressor 1; Metastasis suppressor protein 1; Metastasis suppressor YGL-1; MIM; MIMA; MIMB; missing in metastasis; Missing in metastasis protein; MTSS1
Gene Symbols: MTSS1
Molecular weight: 82,251 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MTSS1

Protein Structure Not Found.


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Sites Implicated In
cell growth, induced: S322‑p
cell motility, induced: S322‑p
molecular association, regulation: S322‑p
protein degradation: S322‑p
ubiquitination: S322‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K36 VWEDFINKAGKLQSQ
0 4 T144-p IKKKSSDtLkLQkkA
0 1 K146-ac KKSSDtLkLQkkAKK
0 1 K149-ac SDtLkLQkkAKKGRG
0 1 K150-ac DtLkLQkkAKKGRGD
0 2 S255 KGSDYSWSYQtPPss
0 28 T258-p DYSWSYQtPPssPSt
0 11 S261-p WSYQtPPssPSttMS
0 12 S262-p SYQtPPssPSttMSR
0 2 S264 QtPPssPSttMSRKS
0 3 T265-p tPPssPSttMSRKSs
0 3 T266-p PPssPSttMSRKSsV
0 2 S268 ssPSttMSRKSsVCs
0 2 S271 SttMSRKSsVCsSLN
0 26 S272-p ttMSRKSsVCsSLNS
0 4 S275-p SRKSsVCsSLNSVNS
0 5 S294-p SSGSHSHsPSSHYRY
0 1 S296 GSHSHsPSSHYRYRS
0 1 Y299 SHsPSSHYRYRSSNL
0 2 S316 QAPVRLSSVSSHDsG
0 1 S319 VRLSSVSSHDsGFIS
1 1 S322-p SSVSSHDsGFISQDA
0 3 Y390-p TSVHLPDyAHyyTIG
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
1 6 Y393-p HLPDyAHyyTIGPGM
1 3 Y394-p LPDyAHyyTIGPGMF
0 1 K414 PSWKDWAKPGPyDQP
0 4 Y418-p DWAKPGPyDQPLVNT
0 2 T425 yDQPLVNTLQRRKEK
0 2 T547 QEFDKSSTIPRNSDI
0 1 K565 YRRMFQAKRPAsTAG
0 1 S569-p FQAKRPAsTAGLPTT
0 1 T570 QAKRPAsTAGLPTTL
0 3 T588-p MVTPGVAtIRRTPst
0 4 T592 GVAtIRRTPstkPsV
0 35 S594-p AtIRRTPstkPsVRR
0 16 T595-p tIRRTPstkPsVRRG
0 1 K596-ac IRRTPstkPsVRRGt
0 3 S598-p RTPstkPsVRRGtIG
0 5 T603-p kPsVRRGtIGAGPIP
0 1 T613-p AGPIPIKtPVIPVKT
0 3 A632 DLPGVLPAPPDGPEE
0 3 S644-p PEERGEHsPESPsVG
0 3 S647 RGEHsPESPsVGEGP
0 2 S649-p EHsPESPsVGEGPQG
0 1 S693 HRQAIPESEAEDQER
0 1 S708 EPPSATVSPGQIPES
0 2 S721 ESDPADLSPRDTPQG
  mouse

► Hide Isoforms
 
K36-ub VWEDFINkAGKLQSQ
T144-p IKNKSSDtLKLQKKA
K146 NKSSDtLKLQKKAKK
K149 SDtLKLQKKAKKVDA
K150 DtLKLQKKAKKVDAQ
S259-p KGSDYSWsYQtPPss
T262-p DYSWsYQtPPssPst
S265-p WsYQtPPssPsttMs
S266-p sYQtPPssPsttMsR
S268-p QtPPssPsttMsRKs
T269-p tPPssPsttMsRKss
T270-p PPssPsttMsRKssV
S272-p ssPsttMsRKssVCs
S275-p sttMsRKssVCsSLN
S276-p ttMsRKssVCsSLNS
S279-p sRKssVCsSLNSVNS
S298-p SSGSHSHsPsSHyRY
S300-p GSHSHsPsSHyRYRS
Y303-p SHsPsSHyRYRSSNL
S320-p QAPVRLSsVSsHDsG
S323-p VRLSsVSsHDsGFIS
S326-p SsVSsHDsGFISQDA
Y394 TSVHLPDYAHyyTIG
- gap
- gap
- gap
- gap
Y397-p HLPDYAHyyTIGPGM
Y398-p LPDYAHyyTIGPGMF
K418-ub PSWKDWAkPGPyDQP
Y422-p DWAkPGPyDQPLVNt
T429-p yDQPLVNtLQRRKEK
T551 QEFDKSSTIPRNSDI
K569-ub YRRMFQAkRPAstAG
S573-p FQAkRPAstAGLPTT
T574-p QAkRPAstAGLPTTL
T592 MVTPGVATIRRtPst
T596-p GVATIRRtPstKPsV
S598-p ATIRRtPstKPsVRR
T599-p TIRRtPstKPsVRRG
K600 IRRtPstKPsVRRGt
S602-p RtPstKPsVRRGtIG
T607-p KPsVRRGtIGAGPIP
T617 AGPIPIKTPVIPVKT
S636-p DLPGVLPsPPDGPEE
S648-p PEERGEHsPEsPsAG
S651-p RGEHsPEsPsAGEGP
S653-p EHsPEsPsAGEGPQG
S697-p HRQAIPEsEAEDQER
S712-p DPPSATVsPGPIPES
S725-p ESDPADLsPRESPQG
  MTSS1 iso4  
K64 VWEDFINKAGKLQSQ
T172 IKKKSSDTLKLQKKA
K174 KKSSDTLKLQKKAKK
K177 SDTLKLQKKAKKGRG
K178 DTLKLQKKAKKGRGD
S283 KGSDYSWSYQTPPSS
T286 DYSWSYQTPPSSPST
S289 WSYQTPPSSPSTTMS
S290 SYQTPPSSPSTTMSR
S292 QTPPSSPSTTMSRKS
T293 TPPSSPSTTMSRKSS
T294 PPSSPSTTMSRKSSV
S296 SSPSTTMSRKSSVCS
S299 STTMSRKSSVCSSLN
S300 TTMSRKSSVCSSLNS
S303 SRKSSVCSSLNSVNS
S322 SSGSHSHSPSSHYRY
S324 GSHSHSPSSHYRYRS
Y327 SHSPSSHYRYRSSNL
S344 QAPVRLSSVSSHDSG
S347 VRLSSVSSHDSGFIS
S350 SSVSSHDSGFISQDA
- gap
S376-p EAANQNSsSSASsEA
S381-p NSsSSASsEAsETCQ
S384-p SSASsEAsETCQSVS
S410-p STMGAWVsTEKDWAK
- gap
- gap
K417 sTEKDWAKPGPYDQP
Y421 DWAKPGPYDQPLVNT
T428 YDQPLVNTLQRRKEK
T565-p QEFDKSStIPRNSDI
K583 YRRMFQAKRPASTAG
S587 FQAKRPASTAGLPTT
T588 QAKRPASTAGLPTTL
T606 MVTPGVATIRRTPST
T610 GVATIRRTPSTKPSV
S612 ATIRRTPSTKPSVRR
T613 TIRRTPSTKPSVRRG
K614 IRRTPSTKPSVRRGT
S616 RTPSTKPSVRRGTIG
T621 KPSVRRGTIGAGPIP
T631 AGPIPIKTPVIPVKT
S650 DLPGVLPSPPDGPEE
S662 PEERGEHSPESPSAG
S665 RGEHSPESPSAGEGP
S667 EHSPESPSAGEGPQG
S711 HRQAIPESEAEDQER
S726 DPPSATVSPGPIPES
S739 ESDPADLSPRESPQG
  rat

 
K67 VWEDFINKAGKLQSQ
T175 IKKKSSDTLKLQKKA
K177 KKSSDTLKLQKKAKK
K180 SDTLKLQKKAKKVDA
K181 DTLKLQKKAKKVDAQ
S290 KGSDYSWSYQTPPSS
T293 DYSWSYQTPPSSPST
S296 WSYQTPPSSPSTTMS
S297 SYQTPPSSPSTTMSR
S299 QTPPSSPSTTMSRKS
T300 TPPSSPSTTMSRKSs
T301 PPSSPSTTMSRKSsV
S303 SSPSTTMSRKSsVCS
S306 STTMSRKSsVCSSLN
S307-p TTMSRKSsVCSSLNS
S310 SRKSsVCSSLNSVNS
S329 SSGSHSHSPSSHYRY
S331 GSHSHSPSSHYRYRS
Y334 SHSPSSHYRYRSSNL
S351 QAPVRLSSVSSHDSG
S354 VRLSSVSSHDSGFIS
S357 SSVSSHDSGFISQDA
Y425 TSIHLPDYAHYYTIG
- gap
- gap
- gap
- gap
Y428 HLPDYAHYYTIGPGM
Y429 LPDYAHYYTIGPGMF
K449 PSWKDWAKPGPYDQP
Y453 DWAKPGPYDQPLVNT
T460 YDQPLVNTLQRRKEK
T582 QEFDKSSTIPRNSDI
K600 YRRMFQAKRPASTAG
S604 FQAKRPASTAGLPTT
T605 QAKRPASTAGLPTTL
T623 MVTPGVATIRRTPST
T627 GVATIRRTPSTKPSV
S629 ATIRRTPSTKPSVRR
T630 TIRRTPSTKPSVRRG
K631 IRRTPSTKPSVRRGT
S633 RTPSTKPSVRRGTIG
T638 KPSVRRGTIGAGPIP
T648 AGPIPIKTPVIPVKT
S667-p DLPGVLPsPPDGPEE
S679 PEERGEHSPESPSVG
S682 RGEHSPESPSVGEGP
S684 EHSPESPSVGEGPQG
S728 HRQAIPESEAEDQER
S743 DPSSTSVSPGPIPES
S756 ESDPADLSPRESPQG
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