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Protein Page:
RAGE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAGE Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral; Cell cycle regulation
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; receptor activity
Biological Process: cell surface receptor linked signal transduction; response to wounding; innate immune response; inflammatory response; neurite development; induction of positive chemotaxis; activation of NF-kappaB transcription factor
Reference #:  Q15109 (UniProtKB)
Alt. Names/Synonyms: advanced glycosylation end product-specific receptor; AGER; MGC22357; RAGE; receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products
Gene Symbols: AGER
Molecular weight: 42,803 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAGE

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 K162 LSWHLDGKPLVPNEK
0 1 - gap
0 1 N378 EERKAPENQEEEEER
2 1 S391-p ERAELNQsEEPEAGE
0 2 S399-p EEPEAGEsSTGGP__
0 1 - gap
0 1 - gap
  RAGE iso2  
- gap
K148 LSWHLDGKPLVPNEK
T271-p LERGAGRtRRGGANC
- gap
- gap
- gap
- gap
- gap
  RAGE iso4  
K150-m3 EESRRSRkRPCEQEV
K178 LSWHLDGKPLVPNEK
- gap
- gap
- gap
- gap
- gap
- gap
  RAGE iso8  
- gap
K162 LSWHLDGKPLVPNEK
- gap
- gap
- gap
- gap
- gap
- gap
  RAGE iso9  
- gap
K162 LSWHLDGKPLVPNEK
- gap
- gap
- gap
- gap
T278-p WMKDGLRtREPTAVW
T291-p VWPPIPAtGPRKAVL
  mouse

 
- gap
K161-ac LSWHLDGkLLIPDGK
- gap
S377-p EERKAPEsQEDEEER
S390-p ERAELNQsEEAEMPE
N398 EEAEMPENGAGGP__
- gap
- gap
  rat

 
- gap
K161 LSWHLDGKPLIPDGK
- gap
S376-p EERKAPEsQEDEEER
S389-p ERAELNQsEEAEMPE
N397 EEAEMPENGAGGP__
- gap
- gap
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