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Protein Page:
RAGE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAGE Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell cycle regulation
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; receptor activity
Biological Process: cell surface receptor linked signal transduction; response to wounding; innate immune response; inflammatory response; neurite development; activation of NF-kappaB transcription factor; induction of positive chemotaxis
Reference #:  Q15109 (UniProtKB)
Alt. Names/Synonyms: advanced glycosylation end product-specific receptor; AGER; MGC22357; RAGE; receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products
Gene Symbols: AGER
Molecular weight: 42,803 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAGE

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 R48 APKKPPQRLEWKLNT
0 1 K52 PPQRLEWKLNTGRTE
0 1 K62 TGRTEAWKVLSPQGG
0 1 K107 QAMNRNGKETKSNYR
0 1 K110 NRNGKETKSNYRVRV
0 1 K123 RVYQIPGKPEIVDSA
0 1 - gap
0 1 K162 LSWHLDGKPLVPNEK
0 1 K174 NEKGVSVKEQTRRHP
0 1 - gap
1 2 N378 EERKAPENQEEEEER
3 2 S391-p ERAELNQsEEPEAGE
0 2 S399-p EEPEAGEsSTGGP__
0 1 - gap
0 1 - gap
  RAGE iso2  
R48 APKKPPQRLEWKLGG
K52 PPQRLEWKLGGGPWD
- gap
K93 QAMNRNGKETKSNYR
K96 NRNGKETKSNYRVRV
K109 RVYQIPGKPEIVDSA
- gap
K148 LSWHLDGKPLVPNEK
K160 NEKGVSVKEQTRRHP
T271-p LERGAGRtRRGGANC
- gap
- gap
- gap
- gap
- gap
  RAGE iso4  
R48 APKKPPQRLEWKLNT
K52 PPQRLEWKLNTGRTE
K62 TGRTEAWKVLSPQGG
K107 QAMNRNGKETKSNYR
K110 NRNGKETKSNYRVRV
K123 RVYQIPGKPEIVDSA
K150-m3 EESRRSRkRPCEQEV
K178 LSWHLDGKPLVPNEK
K190 NEKGVSVKEQTRRHP
- gap
- gap
- gap
- gap
- gap
- gap
  RAGE iso8  
R48 APKKPPQRLEWKLNT
K52 PPQRLEWKLNTGRTE
K62 TGRTEAWKVLSPQGG
K107 QAMNRNGKETKSNYR
K110 NRNGKETKSNYRVRV
K123 RVYQIPGKPEIVDSA
- gap
K162 LSWHLDGKPLVPNEK
K174 NEKGVSVKEQTRRHP
- gap
- gap
- gap
- gap
- gap
- gap
  RAGE iso9  
R48 APKKPPQRLEWKLNT
K52 PPQRLEWKLNTGRTE
K62 TGRTEAWKVLSPQGG
K107 QAMNRNGKETKSNYR
K110 NRNGKETKSNYRVRV
K123 RVYQIPGKPEIVDSA
- gap
K162 LSWHLDGKPLVPNEK
K174 NEKGVSVKEQTRRHP
- gap
- gap
- gap
- gap
T278-p WMKDGLRtREPTAVW
T291-p VWPPIPAtGPRKAVL
  mouse

 
Q48 APKKPPQQLEWKLNT
K52 PPQQLEWKLNTGRTE
K62 TGRTEAWKVLSPQGG
K106 RATNRRGKEVKSNYR
K109 NRRGKEVKSNYRVRV
K122 RVYQIPGKPEIVDPA
- gap
K161-ac LSWHLDGkLLIPDGK
K173 DGKETLVKEETRRHP
- gap
S377-p EERKAPEsQEDEEER
S390-p ERAELNQsEEAEMPE
N398 EEAEMPENGAGGP__
- gap
- gap
  rat

 
K48-ac APKKPTQkLEWkLNT
K52-ac PTQkLEWkLNTGRTE
K62-ac TGRTEAWkVLSPQGD
K106-ac RATNRLGkEVkSNYR
K109-ac NRLGkEVkSNYRVRV
K122-ac RVYQIPGkPEIVNPA
- gap
K161 LSWHLDGKPLIPDGK
K173-ac DGKGTVVkEETRRHP
- gap
S376-p EERKAPEsQEDEEER
S389-p ERAELNQsEEAEMPE
N397 EEAEMPENGAGGP__
- gap
- gap
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