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RAGE
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, misc.; Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis |
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Cellular Component: extracellular space; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; basal plasma membrane
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Molecular Function: protein binding; transmembrane receptor activity; advanced glycation end-product receptor activity; receptor activity
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Biological Process: positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; JAK-STAT cascade; activation of NF-kappaB transcription factor; induction of positive chemotaxis; calcium ion homeostasis; response to hyperoxia; cell surface receptor linked signal transduction; response to wounding; innate immune response; brain development; inflammatory response; neurite development; lung development; positive regulation of inflammatory response
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Reference #:
Q15109 (UniProtKB)
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| Alt. Names/Synonyms: Advanced glycosylation end product-specific receptor; AGER; MGC22357; RAGE; Receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products |
| Gene Symbols: AGER |
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Molecular weight: 42,803 Da
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Basal Isoelectric point: 5.83
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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