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MKP-3 (human)

Overview MKP-3 a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function: protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity Biological Process: response to drug; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; regulation of fibroblast growth factor receptor signaling pathway; toll-like receptor 3 signaling pathway; response to organic cyclic substance; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to nitrosative stress; dorsal/ventral pattern formation; toll-like receptor signaling pathway; innate immune response; regulation of endodermal cell fate specification; cell differentiation; toll-like receptor 4 signaling pathway; inactivation of MAPK activity Reference #:  Q16828 (UniProtKB) Alt. Names/Synonyms: dual specificity phosphatase 6; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; DUSP6; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1; serine/threonine specific protein phosphatase Gene Symbols: DUSP6 Molecular weight: 42,320 Da Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKP-3 1HZM - A=1-154 (human) 1MKP - A=205-347 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HZM 1MKP  |  ENZYME 3.1.3.16 3.1.3.48  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
protein degradation: S159‑p, S174‑p, S197‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K68-u	IMLRRLQkGNLPVRA
4	0		S159-p	DGSCSSSsPPLPVLG
1	0		S174-p	LGGLRISsDSSSDIE
4	0		S197-p	SATDSDGsPLSNSQP
0	5		K254-u	FENAGEFkyKQIPIS
0	1		Y255-p	ENAGEFkyKQIPISD
1	0		S300-p	CLAGISRsVTVTVAY
0	2		K324-u	NDAYDIVkMKKsNIs
0	6		S328-p	DIVkMKKsNIsPNFN
0	10		S331-p	kMKKsNIsPNFNFMG
0	1		S351-p	ERTLGLSsPCDNRVP

	mouse
K68	IMLRRLQKGNLPVRA
S159-p	DGSCSSSsPPLPVLG
S174	LGGLRISSDSSSDIE
S197-p	SATDSDGsPLSNSQP
K254	FENAGEFKYKQIPIS
Y255	ENAGEFKYKQIPISD
S300	CLAGISRSVTVTVAY
K324	NDAYDIVKMKKsNIs
S328-p	DIVKMKKsNIsPNFN
S331-p	KMKKsNIsPNFNFMG
S351	ERTLGLSSPCDNRVP

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