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Protein Page:
MKP-3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKP-3 a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process: response to drug; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; regulation of fibroblast growth factor receptor signaling pathway; toll-like receptor 3 signaling pathway; response to organic cyclic substance; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to nitrosative stress; dorsal/ventral pattern formation; toll-like receptor signaling pathway; innate immune response; regulation of endodermal cell fate specification; toll-like receptor 9 signaling pathway; cell differentiation; toll-like receptor 4 signaling pathway; inactivation of MAPK activity
Reference #:  Q16828 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 6; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; DUSP6; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1; serine/threonine specific protein phosphatase
Gene Symbols: DUSP6
Molecular weight: 42,320 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKP-3

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S159‑p, S174‑p, S197‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K68-ub IMLRRLQkGNLPVRA
4 0 S159-p DGSCSSSsPPLPVLG
1 0 S174-p LGGLRISsDSSSDIE
4 0 S197-p SATDSDGsPLSNSQP
0 5 K254-ub FENAGEFkyKQIPIS
0 1 Y255-p ENAGEFkyKQIPISD
1 0 S300-p CLAGISRsVTVTVAY
0 2 K324-ub NDAYDIVkMKKsNIs
0 7 S328-p DIVkMKKsNIsPNFN
0 11 S331-p kMKKsNIsPNFNFMG
0 1 S351-p ERTLGLSsPCDNRVP
  mouse

 
K68 IMLRRLQKGNLPVRA
S159-p DGSCSSSsPPLPVLG
S174 LGGLRISSDSSSDIE
S197-p SATDSDGsPLSNSQP
K254 FENAGEFKYKQIPIS
Y255 ENAGEFKYKQIPISD
S300 CLAGISRSVTVTVAY
K324 NDAYDIVKMKKsNIs
S328-p DIVKMKKsNIsPNFN
S331-p KMKKsNIsPNFNFMG
S351 ERTLGLSSPCDNRVP
  rat

 
K68 IMLRRLQKGNLPVRA
S159 DGSCSSSSPPLPVLG
S174 LGGLRISSDSSSDIE
S197 SATDSDGSPLSNSQP
K254 FENAGEFKYKQIPIS
Y255 ENAGEFKYKQIPISD
S300 CLAGISRSVTVTVAY
K324 NDAYDIVKMKKSNIS
S328 DIVKMKKSNISPNFN
S331 KMKKSNISPNFNFMG
S351 ERTLGLSSPCDNRVP
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