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Smad6 (human)

Overview Smad6 Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: transcription factor complex; cytoplasm; nucleus; cytosol Molecular Function: protein binding; ubiquitin protein ligase binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; chromatin binding; transcription factor activity Biological Process: positive regulation of S phase of mitotic cell cycle; transcription, DNA-dependent; negative regulation of caspase activity; cell-substrate adhesion; negative regulation of BMP signaling pathway; BMP signaling pathway; zygotic determination of dorsal/ventral axis; ureteric bud development; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of apoptosis Reference #:  O43541 (UniProtKB) Alt. Names/Synonyms: hSMAD6; HsT17432; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD, mothers against DPP homolog 6; SMAD6 Gene Symbols: SMAD6 Molecular weight: 53,497 Da Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states CST Pathways:  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Smad6

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		R75	PRDAVGQRGAQGAGR
0	1		T174	LLEQELKTVTySLLK
0	1		Y177-p	QELKTVTySLLKRLK
0	1		-	gap
0	2		S280-p	ESPPPPYsRLSPRDE
1	0		S435-p	RKVPPGYsIKVFDFE

	Smad6 iso2
-	gap
-	gap
-	gap
S2-p	______MsRMGKPIE
S19-p	KSPPPPYsRLSPRDE
S174	RKVPPGYSIKVFDFE

	mouse
R74-m2	PRDAVGPrGAAIAGR
T175-p	LLEQELKtVTYSLLK
Y178	QELKtVTYSLLKRLK
-	gap
S281	ESPPPPYSRLSPPDQ
S436	RKVPPGYSIKVFDFE

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