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Protein Page:
Smad6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Smad6 Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; protein complex; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; metal ion binding; ubiquitin protein ligase binding; chromatin binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transcription factor activity
Biological Process: fat cell differentiation; transcription, DNA-dependent; cell-substrate adhesion; negative regulation of BMP signaling pathway; BMP signaling pathway; negative regulation of cell proliferation; zygotic determination of dorsal/ventral axis; response to estrogen stimulus; ureteric bud development; transforming growth factor beta receptor signaling pathway; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of apoptosis
Reference #:  O43541 (UniProtKB)
Alt. Names/Synonyms: hSMAD6; HsT17432; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD, mothers against DPP homolog 6; SMAD6
Gene Symbols: SMAD6
Molecular weight: 53,497 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Smad6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 R75 PRDAVGQRGAQGAGR
1 0 K173-ub LLLEQELkTVTYSLL
0 1 T174 LLEQELkTVTYSLLK
0 1 S274-p SRLCGPEsPPPPYsR
0 1 - gap
0 2 S280-p EsPPPPYsRLSPRDE
1 0 S435-p RKVPPGYsIKVFDFE
  Smad6 iso2  
- gap
- gap
- gap
- under review  
S2-p ______MsRMGKPIE
S19-p KSPPPPYsRLSPRDE
S174 RKVPPGYSIKVFDFE
  mouse

 
R74-m2 PRDAVGPrGAAIAGR
K174 LLLEQELKtVTYSLL
T175-p LLEQELKtVTYSLLK
S275 SRLCGPESPPPPYSR
- gap
S281 ESPPPPYSRLSPPDQ
S436 RKVPPGYSIKVFDFE
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