Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CPLX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CPLX2 Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Belongs to the complexin/synaphin family. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein
Cellular Component: mast cell granule; cell soma; dendrite; synapse; cytosol
Molecular Function: syntaxin-1 binding; calcium-dependent protein binding
Biological Process: nervous system development; synaptic vesicle exocytosis; positive regulation of synaptic plasticity; mast cell degranulation; cell differentiation; vesicle docking during exocytosis
Reference #:  Q6PUV4 (UniProtKB)
Alt. Names/Synonyms: 921-L; complexin 2; Complexin II; Complexin-2; CPLX2; CPX II; CPX-2; CPX2; Hfb1; MGC138492; synaphin 1; Synaphin-1
Gene Symbols: CPLX2
Molecular weight: 15,394 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CPLX2

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K14-ac QALGGATkDMGKMLG
0 3 Y70-p RQQIRDKyGLKKKEE
0 3 S93-p LEQPCEGsLTRPKKA
1 1 S115 EEEEEEESILDTVLK
  mouse

 
K14 QALGGATKDMGKMLG
Y70 RQQIRDKYGLKKKEE
S93-p LEQPCEGsLTRPKKA
S115-p EEEEEEEsILDTVLK
  rat

 
K14-ac QALGGATkDMGKMLG
Y70 RQQIRDKYGLKKKEE
S93-p LEQPCEGsLTRPKKA
S115-p EEEEEEEsILDTVLK
  cow

 
K14 QALGGATKDMGKMLG
Y70 RQQIRDKYGLKKKEE
S93 LEQPCEGSLTRPKKA
S115-p EEEEEEEsILDTVLK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.