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Protein Page:
NRBF2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NRBF2 May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand. Detected in keratinocytes, liver and placenta. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; cytoplasm
Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression
Reference #:  Q96F24 (UniProtKB)
Alt. Names/Synonyms: Comodulator of PPAR and RXR; COPR; COPR1; COPR2; DKFZp564C1664; FLJ30395; NRBF-2; NRBF2; nuclear receptor binding factor 2; nuclear receptor binding factor-2; Nuclear receptor-binding factor 2
Gene Symbols: NRBF2
Molecular weight: 32,378 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NRBF2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K85-ac AQREERLkAQQNTDK
0 1 K103-ac AHLQTSHkPSAEDAE
0 2 S113-p AEDAEGQsPLSQKYs
0 1 S120-p sPLSQKYsPSTEKCL
0 21 Y143-p RDPDTLLyLLQQKSE
0 1 T250 WQKFAANTGKAKDIP
0 3 S268-p LPPLDFPsPELPLME
0 1 S277-p ELPLMELsEDILKGF
  mouse

 
K85 AKREERLKAQQSTER
R103 PHLQAPPRPSEDAEG
S112 SEDAEGQSPLLSQPY
I120 PLLSQPYIPSTERRL
F143 RDPDTLLFLLQQKNE
T250-p WQKFAANtGKAKDIP
S268-p LPPLDFPsPELPLME
S277 ELPLMELSEDILKGF
  rat

 
K85 AKREERLKAQQSTDR
R103 PHLQASHRPSEDSEG
S112 SEDSEGQSPLLSQTY
I120 PLLSQTYIPSTEKRL
F143 RDPDTLLFLLQQKNE
T250 WQKFAANTGKAKDIP
S268 LPPLDFPSPELPLME
S277 ELPLMELSEDILKGF
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