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NRBF2 (human)

Overview NRBF2 May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand. Detected in keratinocytes, liver and placenta. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Cellular Component: nucleoplasm; cytoplasm Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression Reference #:  Q96NP6 (UniProtKB) Alt. Names/Synonyms: Comodulator of PPAR and RXR; COPR; COPR1; COPR2; DKFZp564C1664; FLJ30395; NRBF-2; NRBF2; nuclear receptor binding factor 2; nuclear receptor binding factor-2; Nuclear receptor-binding factor 2 Gene Symbols: NRBF2 Molecular weight: 32,378 Da Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NRBF2 2CRB (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K85-a	AQREERLkAQQNTDK
0	1		K103-a	AHLQTSHkPSAEDAE
0	1		S113-p	AEDAEGQsPLSQKYs
0	1		S120-p	sPLSQKYsPSTEKCL
0	37		Y143-p	RDPDTLLyLLQQKSE
0	3		S268-p	LPPLDFPsPELPLME
0	1		S277-p	ELPLMELsEDILKGF

	mouse
K85	AKREERLKAQQSTER
R103	PHLQAPPRPSEDAEG
S112	SEDAEGQSPLLSQPY
I120	PLLSQPYIPSTERRL
F143	RDPDTLLFLLQQKNE
S268-p	LPPLDFPsPELPLME
S277	ELPLMELSEDILKGF

	rat
K85	AKREERLKAQQSTDR
R103	PHLQASHRPSEDSEG
S112	SEDSEGQSPLLSQTY
I120	PLLSQTYIPSTEKRL
F143	RDPDTLLFLLQQKNE
S268	LPPLDFPSPELPLME
S277	ELPLMELSEDILKGF

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