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Protein Page:
NCDN (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NCDN Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. Belongs to the neurochondrin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Cellular Component: cell soma; axon; dendrite; cytosol; nucleus
Biological Process: neurite development; bone resorption; regulation of neuronal synaptic plasticity
Reference #:  Q9UBB6 (UniProtKB)
Alt. Names/Synonyms: KIAA0607; NCDN; Neurochondrin
Gene Symbols: NCDN
Molecular weight: 78,864 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Select Structure to View Below

NCDN

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsCCDLAAA
0 1 K61 AALLLVTKAVKAGDI
0 1 R75 IDAKTRRRIFDAVGF
0 1 T83 IFDAVGFTFPNRLLT
0 2 K92 PNRLLTTKEAPDGCP
0 3 K272-u LARILGSkLSSWQRN
0 6 K283-u WQRNPALkLAARLAH
0 1 S409 WLAEETSSLRKEVCQ
0 1 K412 EETSSLRKEVCQLLP
0 1 S448 QVANLAISPTTPGPT
0 2 K483 GPREILIKEGAPSLL
0 1 S583 MARLLSTSPALQGTP
0 5 Y717 GEETASHYRMAALEQ
  mouse

 
S2-p ______MsCCDLAAA
K61-u AALLLVTkAVKAGDI
R75-m2 IDAKTRRrIFDAVGF
T83-p IFDAVGFtFPNRLLT
K92-u PNRLLTTkEAPDGCP
K272-u LARILGSkLSSWQRN
K283-u WQRNPALkLAARLAH
S409-p WLAEETSsLRkEVCQ
K412-u EETSsLRkEVCQLLP
S448-p QVANLAIsPTTPGPS
K483-u GPREILIkEGAPSLL
S583-p MARLLSTsPALQGTP
Y717 GEETASHYRMAALEQ
  rat

 
S2 ______MSCCDLAAA
K61 AALLLVTKAVKAGDI
R75 IDAKTRRRIFDAVGF
T83 IFDAVGFTFPNRLLT
K92-u PNRLLTTkEAPDGCP
K272-u LARILGSkLSSWQRN
K283-u WQRNPALkLAARLAH
S409 WLAEETSSLRKEVCQ
K412 EETSSLRKEVCQLLP
S448 QVANLAISPTTPGPA
K483-u GPREILIkEGAPSLL
S583 MARLLSTSPALQGTP
Y717-p GEETASHyRMAALEQ
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