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NCDN (human)

Overview NCDN Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. Belongs to the neurochondrin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein Cellular Component: cell soma; axon; dendrite; cytosol; nucleus Biological Process: neurite development; bone resorption; regulation of neuronal synaptic plasticity Reference #:  Q9UBB6 (UniProtKB) Alt. Names/Synonyms: KIAA0607; NCDN; Neurochondrin Gene Symbols: NCDN Molecular weight: 78,864 Da Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states

Select Structure to View Below NCDN

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2	______MSCCDLAAA
0	1		K61	AALLLVTKAVKAGDI
0	1		T83	IFDAVGFTFPNRLLT
0	2		K92	PNRLLTTKEAPDGCP
0	3		K272-u	LARILGSkLSSWQRN
0	6		K283-u	WQRNPALkLAARLAH
0	1		S409	WLAEETSSLRKEVCQ
0	1		K412	EETSSLRKEVCQLLP
0	1		S448	QVANLAISPTTPGPT
0	2		K483	GPREILIKEGAPSLL
0	1		S583	MARLLSTSPALQGTP
0	5		Y717	GEETASHYRMAALEQ

	mouse
S2-p	______MsCCDLAAA
K61-u	AALLLVTkAVKAGDI
T83-p	IFDAVGFtFPNRLLT
K92-u	PNRLLTTkEAPDGCP
K272-u	LARILGSkLSSWQRN
K283-u	WQRNPALkLAARLAH
S409-p	WLAEETSsLRkEVCQ
K412-u	EETSsLRkEVCQLLP
S448-p	QVANLAIsPTTPGPS
K483-u	GPREILIkEGAPSLL
S583-p	MARLLSTsPALQGTP
Y717	GEETASHYRMAALEQ

	rat
S2	______MSCCDLAAA
K61	AALLLVTKAVKAGDI
T83	IFDAVGFTFPNRLLT
K92-u	PNRLLTTkEAPDGCP
K272-u	LARILGSkLSSWQRN
K283-u	WQRNPALkLAARLAH
S409	WLAEETSSLRKEVCQ
K412	EETSSLRKEVCQLLP
S448	QVANLAISPTTPGPA
K483-u	GPREILIkEGAPSLL
S583	MARLLSTSPALQGTP
Y717-p	GEETASHyRMAALEQ

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