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MKP-1 (human)

Overview MKP-1 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.16 Cellular Component: nucleoplasm Molecular Function: protein tyrosine/threonine phosphatase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity Biological Process: response to light stimulus; response to retinoic acid; response to cAMP; positive regulation of apoptosis; response to glucocorticoid stimulus; response to testosterone stimulus; cell cycle; protein amino acid dephosphorylation; response to estradiol stimulus; cellular response to hormone stimulus; regulation of apoptosis; response to hydrogen peroxide; endoderm formation; response to oxidative stress; response to calcium ion; inactivation of MAPK activity Reference #:  P28562 (UniProtKB) Alt. Names/Synonyms: CL100; dual specificity phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; DUSP1; HVH1; MAP kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; Protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase; VH1 Gene Symbols: DUSP1 Molecular weight: 39,298 Da Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  SAPK/JNK Signaling Cascades

Select Structure to View Below MKP-1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME 3.1.3.16 3.1.3.48  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S296‑p, S323‑p protein degradation: S296‑p, S323‑p protein stabilization: S359‑p, S364‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K57	TIVRRRAKGAMGLEH
0	1		K97-a	SAALDGAkRDGTLAL
0	1		S140-p	PELCSKQstPMGLsL
0	1		T141-p	ELCSKQstPMGLsLP
0	1		S146-p	QstPMGLsLPLSTSV
0	1		K230-u	IPVEDNHkADISSWF
0	4		K280-u	LMRTNRVkLDEAFEF
0	3		K289-u	DEAFEFVkQRRSIIs
1	0		S296-p	kQRRSIIsPNFSFMG
1	0		S323-p	HCSAEAGsPAMAVLD
3	0		S359-p	SALSYLQsPITTsPS
1	0		S364-p	LQsPITTsPSC____

	mouse
K57-a	TIVRRRAkGAMGLEH
K97	SASLDGAKRDGTLAL
S140	PELCSKQSTPTGLSL
T141	ELCSKQSTPTGLSLP
S146	QSTPTGLSLPLSTSV
K230	IPVEDNHKADISSWF
K280	LMRTNRVKLDEAFEF
K289	DEAFEFVKQRRSIIS
S296	KQRRSIISPNFSFMG
S323	HCSAEAGSPAMAVLD
S359-p	SALNYLKsPITTSPS
S364	LKsPITTSPSC____

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