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Protein Page:
MKP-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKP-1 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16
Cellular Component: cytoplasm; nucleus
Molecular Function: protein tyrosine/threonine phosphatase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process: negative regulation of MAP kinase activity; response to light stimulus; response to cAMP; response to retinoic acid; positive regulation of apoptosis; negative regulation of MAPKKK cascade; response to glucocorticoid stimulus; negative regulation of meiotic cell cycle; response to testosterone stimulus; protein amino acid dephosphorylation; response to estradiol stimulus; cellular response to hormone stimulus; regulation of apoptosis; response to hydrogen peroxide; endoderm formation; response to oxidative stress; response to calcium ion; negative regulation of apoptosis; inactivation of MAPK activity
Reference #:  P28562 (UniProtKB)
Alt. Names/Synonyms: CL100; dual specificity phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; DUSP1; HVH1; MAP kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; Protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase; VH1
Gene Symbols: DUSP1
Molecular weight: 39,298 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Select Structure to View Below

MKP-1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S296‑p, S323‑p
protein degradation: S296‑p, S323‑p
protein stabilization: S359‑p, S364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K57 TIVRRRAKGAMGLEH
0 1 K97-ac SAALDGAkRDGTLAL
0 1 S140-p PELCSKQstPMGLsL
0 1 T141-p ELCSKQstPMGLsLP
0 1 S146-p QstPMGLsLPLSTSV
0 1 K230-ub IPVEDNHkADISSWF
0 4 K280-ub LMRTNRVkLDEAFEF
0 3 K289-ub DEAFEFVkQRRSIIs
1 0 S296-p kQRRSIIsPNFSFMG
1 0 S323-p HCSAEAGsPAMAVLD
4 0 S359-p SALSYLQsPITTsPS
2 0 S364-p LQsPITTsPSC____
2857 : Phospho-MKP1 (Ser359) (125E2) Rabbit mAb
  mouse

 
K57-ac TIVRRRAkGAMGLEH
K97 SASLDGAKRDGTLAL
S140 PELCSKQSTPTGLSL
T141 ELCSKQSTPTGLSLP
S146 QSTPTGLSLPLSTSV
K230 IPVEDNHKADISSWF
K280 LMRTNRVKLDEAFEF
K289 DEAFEFVKQRRSIIS
S296 KQRRSIISPNFSFMG
S323 HCSAEAGSPAMAVLD
S359-p SALNYLKsPITTSPS
S364 LKsPITTSPSC____
2857 : Phospho-MKP1 (Ser359) (125E2) Rabbit mAb
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