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MKP-2 (human)

Overview MKP-2 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Induced by hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) in human endothelial cells. Two alternatively spliced isoforms have been described. In addition, multiple polyadenylation sites have been reported. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB. Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48 Cellular Component: nucleoplasm; nucleus Molecular Function: protein tyrosine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity Biological Process: nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid dephosphorylation; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to organic substance; endoderm formation; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; inactivation of MAPK activity Reference #:  Q13115 (UniProtKB) Alt. Names/Synonyms: dual specificity phosphatase 4; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUS4; DUSP4; HVH2; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP-2; MKP2; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2; VH2 Gene Symbols: DUSP4 Molecular weight: 42,953 Da Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  SAPK/JNK Signaling Cascades Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKP-2 3EZZ - F/A/D/C/E/B=194-336 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME 3.1.3.16 3.1.3.48  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K16-u	EMDCSVLkRLMNRDE
0	1		Y60-p	FLAHSAGyILGsVNV
0	1		S64-p	SAGyILGsVNVRCNt
0	1		T71-p	sVNVRCNtIVRRRAk
0	1		K78-u	tIVRRRAkGSVSLEQ
0	2		Y102-p	ARLRSGLySAVIVyD
0	4		Y108-p	LySAVIVyDERSPRA
0	1		-	gap
0	1		-	gap
0	2		K160-u	EYPEFCSkTKALAAI
0	2		K311-u	EEAFEFVkQRRSIIS
0	1		T356-p	PLRERGKtPAtPTSQ
1	0		P357	LRERGKtPAtPTSQF
1	1		T359-p	ERGKtPAtPTSQFVF
1	3		S386-p	SSLPYLHsPITTsPS
1	3		S391-p	LHsPITTsPSC____

	MKP-2 iso2
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S33-p	CKPVRAPsMALGVsQ
S39-p	PsMALGVsQLAGRSR
K69	EYPEFCSKTKALAAI
K220	EEAFEFVKQRRSIIS
T265	PLRERGKTPATPTSQ
P266	LRERGKTPATPTSQF
T268	ERGKTPATPTSQFVF
S295	SSLPYLHSPITTSPS
S300	LHSPITTSPSC____

	mouse
K16	EMDCSVLKRLMNRDE
Y64	FLAHSAGYIRGSVNV
S68	SAGYIRGSVNVRCNT
T75	SVNVRCNTIVRRRAK
K82	TIVRRRAKGSVSLEQ
Y106	ARLRSGLYSAVIVYD
Y112	LYSAVIVYDERSPRA
-	gap
-	gap
K164	EYPEFCSKTKALAAI
K315	EEAFEFVKQRRSIIS
A360	PLRERGKAtPtPTSQ
T361-p	LRERGKAtPtPTSQF
T363-p	ERGKAtPtPTSQFVF
S390-p	SNLPYLHsPITTsPS
S395-p	LHsPITTsPSC____

	rat
K16	EMDCSVLKRLMNRDE
Y61	FLAHSAGYIRGSVNV
S65	SAGYIRGSVNVRCNT
T72	SVNVRCNTIVRRRAK
K79	TIVRRRAKGSVSLEQ
Y103	ARLRSGLYSAVIVyD
Y109-p	LYSAVIVyDERSPRA
-	gap
-	gap
K161	EYPEFCSKTKALAAI
K312	EEAFEFVKQRRSIIS
A357	PLRERGKATPTPTSQ
T358	LRERGKATPTPTSQF
T360	ERGKATPTPTSQFVF
S387	SNLPYLHSPITTSPS
S392	LHSPITTSPSC____

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