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Protein Page:
MKP-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKP-2 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Induced by hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) in human endothelial cells. Two alternatively spliced isoforms have been described. In addition, multiple polyadenylation sites have been reported. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein tyrosine/threonine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process: nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid dephosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; endoderm formation; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; inactivation of MAPK activity
Reference #:  Q13115 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 4; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUS4; DUSP4; HVH2; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP-2; MKP2; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2; VH2
Gene Symbols: DUSP4
Molecular weight: 42,953 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKP-2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K16-ub EMDCSVLkRLMNRDE
0 1 Y60-p FLAHSAGyILGsVNV
0 1 S64-p SAGyILGsVNVRCNt
0 1 T71-p sVNVRCNtIVRRRAk
0 1 K78-ub tIVRRRAkGSVSLEQ
0 2 Y102-p ARLRSGLySAVIVyD
0 4 Y108-p LySAVIVyDERSPRA
0 1 - gap
0 1 - gap
0 1 I140 RNAERTDICLLKGGY
0 1 L142 AERTDICLLKGGYER
0 1 Y147 ICLLKGGYERFSSEy
0 1 Y154-p YERFSSEyPEFCskT
0 1 S159-p SEyPEFCskTKALAA
0 2 K160-ub EyPEFCskTKALAAI
0 2 K311-ub EEAFEFVkQRRSIIS
0 1 T356-p PLRERGKtPAtPTSQ
1 0 P357 LRERGKtPAtPTSQF
1 1 T359-p ERGKtPAtPTSQFVF
2 3 S386-p SSLPYLHsPITTsPS
2 3 S391-p LHsPITTsPSC____
  MKP-2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S33-p CKPVRAPsMALGVsQ
S39-p PsMALGVsQLAGRSR
S50-p GRSRCLCsEsQGGyE
S52-p SRCLCsEsQGGyERF
Y56-p CsEsQGGyERFSSEY
Y63 yERFSSEYPEFCSKT
S68 SEYPEFCSKTKALAA
K69 EYPEFCSKTKALAAI
K220 EEAFEFVKQRRSIIS
T265 PLRERGKTPATPTSQ
P266 LRERGKTPATPTSQF
T268 ERGKTPATPTSQFVF
S295 SSLPYLHSPITTSPS
S300 LHSPITTSPSC____
  mouse

 
K16 EMDCSVLKRLMNRDE
Y64 FLAHSAGYIRGSVNV
S68 SAGYIRGSVNVRCNT
T75 SVNVRCNTIVRRRAK
K82 TIVRRRAKGSVSLEQ
Y106 ARLRSGLYSAVIVYD
Y112 LYSAVIVYDERSPRA
- gap
- gap
I144 RNAERTDICLLKGGY
L146 AERTDICLLKGGYER
Y151 ICLLKGGYERFSSEY
Y158 YERFSSEYPEFCSKT
S163 SEYPEFCSKTKALAA
K164 EYPEFCSKTKALAAI
K315 EEAFEFVKQRRSIIS
A360 PLRERGKAtPtPTSQ
T361-p LRERGKAtPtPTSQF
T363-p ERGKAtPtPTSQFVF
S390-p SNLPYLHsPITTsPS
S395-p LHsPITTsPSC____
  rat

 
K16 EMDCSVLKRLMNRDE
Y61 FLAHSAGYIRGSVNV
S65 SAGYIRGSVNVRCNT
T72 SVNVRCNTIVRRRAK
K79 TIVRRRAKGSVSLEQ
Y103 ARLRSGLYSAVIVyD
Y109-p LYSAVIVyDERSPRA
- gap
- gap
I141 RNAERTDICLLKGGY
L143 AERTDICLLKGGYER
Y148 ICLLKGGYERFSSEY
Y155 YERFSSEYPEFCSKT
S160 SEYPEFCSKTKALAA
K161 EYPEFCSKTKALAAI
K312 EEAFEFVKQRRSIIS
A357 PLRERGKATPTPTSQ
T358 LRERGKATPTPTSQF
T360 ERGKATPTPTSQFVF
S387 SNLPYLHSPITTSPS
S392 LHSPITTSPSC____
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