Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: early endosome membrane; early endosome
Molecular Function: protein binding; serine-type peptidase activity; metal ion binding; phosphatidylinositol binding
Biological Process: transforming growth factor beta receptor signaling pathway; endocytosis; SMAD protein nuclear translocation; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis; SMAD protein complex assembly
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.