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Protein Page:
SARA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SARA Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: early endosome membrane; early endosome
Molecular Function: protein binding; serine-type peptidase activity; metal ion binding; phosphatidylinositol binding
Biological Process: transforming growth factor beta receptor signaling pathway; endocytosis; SMAD protein nuclear translocation; proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway; SMAD protein complex assembly
Reference #:  O95405 (UniProtKB)
Alt. Names/Synonyms: hSARA; MAD homolog interacting protein; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; Madh-interacting protein; MADHIP; mothers against decapentaplegic homolog interacting protein; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; Receptor activation anchor; SARA; Smad anchor for receptor activation; SMADIP; ZFYV9; ZFYVE9; Zinc finger FYVE domain-containing protein 9; zinc finger, FYVE domain containing 9
Gene Symbols: ZFYVE9
Molecular weight: 156,403 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SARA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T26-p FEQNEDEtVsStLLD
0 3 S28-p QNEDEtVsStLLDTK
0 1 T30-p EDEtVsStLLDTKWN
0 1 S77 KVFSLAHSAPLTTEE
0 1 Y120-p DQLIKRNysWDDQCS
0 10 S121-p QLIKRNysWDDQCSA
0 1 T192 LDNENRQTDQFSFSI
0 1 S257-p GSIGRDPsMSAITSL
0 1 S271-p LTVDSVIssQGtDGC
0 1 S272-p TVDSVIssQGtDGCP
0 1 T275-p SVIssQGtDGCPAVK
0 1 T302-p GKISSPRtDLGsPNs
0 3 S306-p SPRtDLGsPNsFSHM
0 2 S309-p tDLGsPNsFSHMSEG
0 1 S413-p KLNEMNDsQVNEEKE
0 1 T503-p PSKEDSVtEEKEIEE
0 7 Y516-p EESKSECySNIyEQR
0 4 Y520-p SECySNIyEQRGNEA
0 1 K543 NSTGDLMKKNYLHNF
0 1 S562-p PSVLGQSsPKVVASL
0 1 S635-p ATNVCSPsLGNISNV
0 2 S668-p CLALAPDsPDNDLRA
0 1 S884 DICLFSGSITQVGSP
0 1 Y1116 LLADFRNYQYTLPVV
0 1 Y1118 ADFRNYQYTLPVVQG
0 1 T1119 DFRNYQYTLPVVQGL
0 1 T1135 VDMEVRKTSIKIPSN
0 1 S1141 KTSIKIPSNRYNEMM
0 1 K1286 VVSPIDGKSMETITN
  mouse

 
T26 FEQNEDETVsPTLLD
S28-p QNEDETVsPTLLDTK
T30 EDETVsPTLLDTKWN
S76 KVFSLAGSAPLTKED
Y119 DQLIKRNYNQDDQFS
N120 QLIKRNYNQDDQFSA
T191-p LDNETRQtDQFSFSM
S256 ENVGRDPSTSTVTSL
S267 VTSLAVNSSQGMDGG
S268 TSLAVNSSQGMDGGP
M271 AVNSSQGMDGGPAIK
T298 GMNSSSRTDLGISNS
I302 SSRTDLGISNSFSHS
S305 TDLGISNSFSHSSGE
S388 KLNEMSDSQVNEENQ
T476 PSKEDSVTEEKEIEE
Y489 EESKSECYSNIYEQR
Y493 SECYSNIYEQRGNEN
K516-ub NSTGNVMkKNYLHNF
S535 PSVLGQSSPKIANLQ
T607 AVNACSATLGNISVT
S640-p CLALAPDsPDNDLRA
S856-p DTSLFSGsITQVGSP
Y1088-p LLADFRNyQytLPVV
Y1090-p ADFRNyQytLPVVQG
T1091-p DFRNyQytLPVVQGL
T1107-p VDMEVRKtSIKIPsN
S1113-p KtSIKIPsNRYNEMM
K1258-ub VVSPIDGkSMESITN
  rat

 
T26 FEQNEDETVSPTLLD
S28 QNEDETVSPTLLDTK
T30 EDETVSPTLLDTKWN
S77-p KIFSLAGsAPLTREG
Y120 DQLIKRNYNQDDQFS
N121 QLIKRNYNQDDQFSA
T192 LDNETRQTDQFSFSM
S257 ENVGRDPSTSTATSL
T268 ATSLAINTSQGMDGG
S269 TSLAINTSQGMDGGP
M272 AINTSQGMDGGPAIK
T299 GANSSSRTDLGSSNS
S303 SSRTDLGSSNSFSHS
S306 TDLGSSNSFSHSREE
R389 KLNEVDDRQGSEENQ
T477 PSKEDSVTEEKEIEE
Y490 EESKSECYSNLYEQR
Y494 SECYSNLYEQRGNEN
K517 NSTGTIMKKNYLHNF
S536 PSVLGQSSPKIANLQ
T608 AVSACSATLGNISVT
S641 CLALSPDSPDNDLRA
S857 DVSLFSGSITQVGSP
Y1089 LLADFRNYQYTLPGV
Y1091 ADFRNYQYTLPGVQG
T1092 DFRNYQYTLPGVQGL
T1108 VDMEVRKTSIKIPSN
S1114 KTSIKIPSNRYNEMM
K1259 VVSPIDGKSMESITN
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