Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SARA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SARA Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: early endosome membrane; early endosome
Molecular Function: protein binding; serine-type peptidase activity; metal ion binding; phosphatidylinositol binding
Biological Process: metabolic process; transforming growth factor beta receptor signaling pathway; endocytosis; SMAD protein nuclear translocation; negative regulation of transforming growth factor beta receptor signaling pathway; SMAD protein complex assembly
Reference #:  O95405 (UniProtKB)
Alt. Names/Synonyms: hSARA; MAD homolog interacting protein; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; Madh-interacting protein; MADHIP; mothers against decapentaplegic homolog interacting protein; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; Receptor activation anchor; SARA; Smad anchor for receptor activation; SMADIP; ZFYV9; ZFYVE9; Zinc finger FYVE domain-containing protein 9; zinc finger, FYVE domain containing 9
Gene Symbols: ZFYVE9
Molecular weight: 156,403 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SARA

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S28-p QNEDETVsSTLLDTK
0 1 S77 KVFSLAHSAPLTTEE
0 9 S121-p QLIKRNYsWDDQCSA
0 1 T192 LDNENRQTDQFSFSI
0 1 S306-p SPRTDLGsPNsFSHM
0 1 S309-p TDLGsPNsFSHMSEG
0 7 Y516-p EESKSECySNIyEQR
0 4 Y520-p SECySNIyEQRGNEA
0 1 K543 NSTGDLMKKNYLHNF
0 1 S635-p ATNVCSPsLGNISNV
0 1 S668 CLALAPDSPDNDLRA
0 1 Y1116 LLADFRNYQYTLPVV
0 1 Y1118 ADFRNYQYTLPVVQG
0 1 T1119 DFRNYQYTLPVVQGL
0 1 T1135 VDMEVRKTSIKIPSN
0 1 S1141 KTSIKIPSNRYNEMM
0 1 K1286 VVSPIDGKSMETITN
  mouse

 
S28-p QNEDETVsPTLLDTK
S76 KVFSLAGSAPLTKED
N120 QLIKRNYNQDDQFSA
T191-p LDNETRQtDQFSFSM
I302 SSRTDLGISNSFSHS
S305 TDLGISNSFSHSSGE
Y489 EESKSECYSNIYEQR
Y493 SECYSNIYEQRGNEN
K516-u NSTGNVMkKNYLHNF
T607 AVNACSATLGNISVT
S640-p CLALAPDsPDNDLRA
Y1088-p LLADFRNyQytLPVV
Y1090-p ADFRNyQytLPVVQG
T1091-p DFRNyQytLPVVQGL
T1107-p VDMEVRKtSIKIPsN
S1113-p KtSIKIPsNRYNEMM
K1258-u VVSPIDGkSMESITN
  rat

 
S28 QNEDETVSPTLLDTK
S77-p KIFSLAGsAPLTREG
N121 QLIKRNYNQDDQFSA
T192 LDNETRQTDQFSFSM
S303 SSRTDLGSSNSFSHS
S306 TDLGSSNSFSHSREE
Y490 EESKSECYSNLYEQR
Y494 SECYSNLYEQRGNEN
K517 NSTGTIMKKNYLHNF
T608 AVSACSATLGNISVT
S641 CLALSPDSPDNDLRA
Y1089 LLADFRNYQYTLPGV
Y1091 ADFRNYQYTLPGVQG
T1092 DFRNYQYTLPGVQGL
T1108 VDMEVRKTSIKIPSN
S1114 KTSIKIPSNRYNEMM
K1259 VVSPIDGKSMESITN
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.