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Protein Page:
DAZ1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DAZ1 RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. Defects in DAZ1 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; translation activator activity; RNA binding; nucleotide binding
Biological Process: positive regulation of translational initiation; multicellular organismal development; spermatogenesis; cell differentiation
Reference #:  Q9NQZ3 (UniProtKB)
Alt. Names/Synonyms: DAZ; DAZ1; deleted in azoospermia 1; Deleted in azoospermia protein 1; FLJ17175; SPGY
Gene Symbols: DAZ1
Molecular weight: 82,764 Da
Basal Isoelectric point: 9.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAZ1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 K36-ub GWVLPEGkIVPNTVF
0 9 K67-ub FGRYGSVkEVkIITN
0 5 K70-ub YGSVkEVkIITNRTG
0 12 K80-ub TNRTGVSkGYGFVSF
0 13 K95-ub VNDVDVQkIVGSQIH
0 11 K106-ub SQIHFHGkkLkLGPA
0 6 K107-ub QIHFHGkkLkLGPAI
0 7 K109-ub HFHGkkLkLGPAIRk
0 2 K116-ub kLGPAIRkQkLCARH
0 5 K118-ub GPAIRkQkLCARHVQ
0 9 K201-ub GWVLPEGkIVPNTVF
0 9 K232-ub FGRYGSVkEVkIITN
0 5 K235-ub YGSVkEVkIITNRTG
0 12 K245-ub TNRTGVSkGYGFVSF
0 13 K260-ub VNDVDVQkIVGSQIH
0 11 K271-ub SQIHFHGkkLkLGPA
0 6 K272-ub QIHFHGkkLkLGPAI
0 7 K274-ub HFHGkkLkLGPAIRk
0 2 K281-ub kLGPAIRkQkLCARH
0 5 K283-ub GPAIRkQkLCARHVQ
0 9 K366-ub GWVLPEGkIVPNTVF
0 9 K397-ub FGRYGSVkEVkIITN
0 5 K400-ub YGSVkEVkIITNRTG
0 12 K410-ub TNRTGVSkGYGFVSF
0 13 K425-ub VNDVDVQkIVGSQIH
0 11 K436-ub SQIHFHGkkLkLGPA
0 6 K437-ub QIHFHGkkLkLGPAI
0 7 K439-ub HFHGkkLkLGPAIRk
0 2 K446-ub kLGPAIRkQkLCARH
0 5 K448-ub GPAIRkQkLCARHVQ
0 1 Y680-p PFQVTTGyQLPVyNy
0 1 Y685-p TGyQLPVyNyQAFPA
0 1 Y687-p yQLPVyNyQAFPAYP
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