Home

ERK1 (mouse)

Overview ERK1 p42 MAP kinase plays a critical role in the regulation of cell growth and differentiation. Activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by a single upstream MAP kinase kinase, MEK. Note: This description may include information from UniProtKB. Protein type: EC 2.7.1.123; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily Cellular Component: Golgi apparatus; focal adhesion; protein complex; mitochondrion; early endosome; pseudopodium; caveola; cytosol; nucleoplasm; microtubule cytoskeleton; cytoskeleton; late endosome; cytoplasm; intracellular; nucleus Molecular Function: transferase activity; MAP kinase activity; protein serine/threonine kinase activity; protein binding; phosphotyrosine binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; phosphatase binding; protein kinase activity Biological Process: positive regulation of translation; positive regulation of histone phosphorylation; metabolic process; apoptosis; response to toxin; response to lipopolysaccharide; sensory perception of pain; signal transduction; protein amino acid phosphorylation; BMP signaling pathway; response to exogenous dsRNA; regulation of transcription factor activity; lipopolysaccharide-mediated signaling pathway; protein complex assembly; transcription, DNA-dependent; MAPKKK cascade; cell cycle; regulation of stress-activated MAPK cascade; organ morphogenesis; nuclear translocation of MAPK; cartilage development; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; phosphorylation; response to DNA damage stimulus; regulation of cytoskeleton organization and biogenesis Reference #:  Q63844 (UniProtKB) Alt. Names/Synonyms: ERK-1; Erk1; ERT2; Esrk1; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; Mapk3; Microtubule-associated protein 2 kinase; mitogen activated protein kinase 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MK03; MNK1; Mtap2k; OTTMUSP00000017735; p44; p44 MAP kinase; p44-ERK1; p44-MAPK; p44erk1; p44mapk; pp42/MAP kinase; Prkm3; protein kinase, mitogen activated kinase 3 Gene Symbols: Mapk3 Molecular weight: 43,066 Da Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ERK1 2ZOQ - A/B=1-379 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  UCSD-Nature A000874 A003852 A004160  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: T203‑p, Y205‑p enzymatic activity, induced: T203‑p, Y205‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		Y61	YGMVSSAYDHVRKTR
0	1		K73	KTRVAIKKISPFEHQ
0	1		T128-p	IVQDLMEtDLyKLLK
0	3		Y131-p	DLMEtDLyKLLKSQQ
0	1		S171	LHRDLKPSNLLINTT
0	2		K182	INTTCDLKICDFGLA
0	2		K182	INTTCDLKICDFGLA
0	12		T199-p	ADPEHDHtGFLtEyV
959	1992		T203-p	HDHtGFLtEyVAtRW
979	3562		Y205-p	HtGFLtEyVAtRWyR
0	38		T208-p	FLtEyVAtRWyRAPE
1	0		Y211-p	EyVAtRWyRAPEIML
0	3		K221-u	PEIMLNSkGYTKSID
0	1		K288	YLQSLPSKTKVAWAK
0	1		K295	KTKVAWAKLFPKSDS

	human
Y60	YGMVSSAYDHVRKTR
K72-u	KTRVAIKkISPFEHQ
T127	IVQDLMETDLyKLLK
Y130-p	DLMETDLyKLLKSQQ
S170-p	LHRDLKPsNLLINTT
K181-a	INTTCDLkICDFGLA
K181-u	INTTCDLkICDFGLA
T198-p	ADPEHDHtGFLtEyV
T202-p	HDHtGFLtEyVAtRW
Y204-p	HtGFLtEyVAtRWyR
T207-p	FLtEyVAtRWyRAPE
Y210-p	EyVAtRWyRAPEIML
K220-u	PEIMLNSkGYTKSID
K287-u	YLQSLPSkTKVAWAk
K294-u	kTKVAWAkLFPKSDS

	rat
Y61-p	YGMVSSAyDHVRKTR
K73	KTRVAIKKISPFEHQ
T128	IVQDLMETDLYKLLK
Y131	DLMETDLYKLLKSQQ
S171	LHRDLKPSNLLINTT
K182	INTTCDLKICDFGLA
K182	INTTCDLKICDFGLA
T199	ADPEHDHTGFLtEyV
T203-p	HDHTGFLtEyVATRW
Y205-p	HTGFLtEyVATRWYR
T208	FLtEyVATRWYRAPE
Y211	EyVATRWYRAPEIML
K221	PEIMLNSKGYTKSID
K288	YLQSLPSKTKVAWAK
K295	KTKVAWAKLFPKSDS

	hamster
Y50	YGMVSSAYDHVRKTR
K62	KTRVAIKKISPFEHQ
T117	IVQDLMETDLYKLLK
Y120	DLMETDLYKLLKSQQ
S160	LHRDLKPSNLLINTT
K171	INTTCDLKICDFGLA
K171	INTTCDLKICDFGLA
T188	ADPEHDHTGFLtEyV
T192-p	HDHTGFLtEyVATRW
Y194-p	HTGFLtEyVATRWYR
T197	FLtEyVATRWYRAPE
Y200	EyVATRWYRAPEIML
K210	PEIMLNSKGYTKSID
K277	YLQSLPSKTKVAWAK
K284	KTKVAWAKLFPKSDS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.