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Akt1 (fruit fly)

Overview Akt1 an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 120 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; AKT family Cellular Component: cell surface; cytoplasm; plasma membrane Molecular Function: protein serine/threonine kinase activity; phospholipid binding; phosphoinositide binding; ATP binding; protein kinase activity Biological Process: circadian rhythm; positive regulation of axon regeneration; positive regulation of cell size; chitin-based embryonic cuticle biosynthetic process; regulation of dendrite development; regulation of multicellular organism growth; regulation of organ growth; positive regulation of multicellular organism growth; epithelial cell migration, open tracheal system; positive regulation of cell growth; protein amino acid phosphorylation; positive regulation of organ growth; dendrite regeneration; regulation of protein import into nucleus; regulation of cell shape; sequestering of lipid; regulation of hemocyte proliferation; open tracheal system development; insulin receptor signaling pathway; response to oxidative stress; regulation of cell size; negative regulation of apoptosis Reference #:  Q8INB9 (UniProtKB) Gene Symbols: Akt1 Molecular weight: 68,485 Da Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Akt1 1H10 - A=1-123 (human) 1UNP - A=1-121 (human) 1UNQ - A=1-123 (human) 1UNR - A=1-123 (human) 2UVM - A=1-123 (human) 2UZR - A=1-123 (human) 2UZS - A=1-123 (human) 3CQU - A=144-480 (human) 3CQW - A=144-480 (human) 3MV5 - A=144-480 (human) 3MVH - A=144-480 (human) 3O96 - A=2-443 (human) 3OCB - A/B=144-480 (human) 3OW4 - A/B=144-480 (human) 3QKK - A=144-480 (human) 3QKL - A=144-480 (human) 3QKM - A=144-480 (human) 4EJN - A=2-446 (human) 4EKK - A/B=144-480 (human) 4EKL - A=144-480 (human) 4GV1 - A=144-480 (human) Substrate Sequence Logo

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			fruit fly
1	1		K109	TEQTQVVKEGWLMKR
1	0		K115	VKEGWLMKRGEHIKN
0	2		H131	RQRYFVLHSDGRLMG
1	0		R135	FVLHSDGRLMGYRSK
0	1		T167	VRGCQIMTVDRPKPF
1	0		T175	VDRPKPFTFIIRGLQ
0	1		T190	WTTVIERTFAVESEL
0	1		S195	ERTFAVESELERQQW
0	1		M229	TPSEQTDMTDVDMAT
0	6		M234	TDMTDVDMATIAEDE
4	5		T236	MTDVDMATIAEDELS
0	1		A238	DVDMATIAEDELSEQ
0	9		A238	DVDMATIAEDELSEQ
0	1		E241	MATIAEDELSEQFSV
5	17		E241	MATIAEDELSEQFSV
0	1		-	gap
0	9		T262	SSGVKKVTLENFEFL
1	1		Y292	EKATAKLYAIKILKK
1	0		T362	LSHERIFTEDRTRFY
0	2		K391	GIIYRDLKLENLLLD
1	1		T420	EDITYGRTTKTFCGT
0	6		T420	EDITYGRTTKTFCGT
448	13		T423	TYGRTTKTFCGTPEY
1	1		T427	TTKTFCGTPEYLAPE
0	2		T427	TTKTFCGTPEYLAPE
4	13		Y430	TFCGTPEYLAPEVLD
3	26		Y441	EVLDDNDYGQAVDWW
0	2		K492	RNITDEAKNLLAGLL
0	2		V532	SINWTDLVLKKIPPP
0	1		K535	WTDLVLKKIPPPFKP
0	1		K541	KKIPPPFKPQVTSDT
0	3		Y552	TSDTDTRYFDKEFTG
18	1		T565	TGESVELTPPDPTGP
1119	49		S586	EPLFPQFSYQGDMAS
2	0		S586	EPLFPQFSYQGDMAS
1	14		Y587	PLFPQFSYQGDMAST
0	3		Q588	LFPQFSYQGDMASTL
1	3		T603	GTSSHISTSTSLASM
0	10		T605	SSHISTSTSLASMQ_

	human
K8-u	MSDVAIVkEGWLHkR
K14-u	VkEGWLHkRGEYIKT
K30-u	RPRYFLLkNDGTFIG
T34	FLLkNDGTFIGYKER
T65-p	AQCQLMKtERPRPNt
T72-p	tERPRPNtFIIRCLQ
T87-p	WTTVIERtFHVEtPE
T92-p	ERtFHVEtPEEREEW
E117	LKKQEEEEMDFRsGs
S122-p	EEEMDFRsGsPsDNs
S124-p	EMDFRsGsPsDNsGA
S126-gl	DFRsGsPsDNsGAEE
S126-p	DFRsGsPsDNsGAEE
S129-gl	sGsPsDNsGAEEMEV
S129-p	sGsPsDNsGAEEMEV
S137	GAEEMEVSLAKPKHR
T146-p	AKPKHRVtMNEFEYL
Y176-p	EKATGRYyAMKILKK
S246-p	LSRERVFsEDRARFY
K276-u	NVVYRDLkLENLMLD
T305-gl	EGIKDGAtMKtFCGt
T305-p	EGIKDGAtMKtFCGt
T308-p	KDGAtMKtFCGtPEy
T312-gl	tMKtFCGtPEyLAPE
T312-p	tMKtFCGtPEyLAPE
Y315-p	tFCGtPEyLAPEVLE
Y326-p	EVLEDNDyGRAVDWW
K377-u	RTLGPEAkSLLSGLL
Y417-p	GIVWQHVyEKkLSPP
K420-a	WQHVyEKkLSPPFkP
K426-a	KkLSPPFkPQVTSET
Y437-p	TSETDTRyFDEEFTA
T450-p	TAQMITItPPDQDDS
S473-p	RPHFPQFsysAsGtA
S473	RPHFPQFSysAsGtA
Y474-p	PHFPQFsysAsGtA_
S475-p	HFPQFsysAsGtA__
S477-p	PQFsysAsGtA____
T479-p	FsysAsGtA______

	mouse
K8	MNDVAIVKEGWLHKR
K14	VKEGWLHKRGEYIKT
K30-u	RPRYFLLkNDGTFIG
T34	FLLkNDGTFIGYKER
T65	AQCQLMKTERPRPNT
T72	TERPRPNTFIIRCLQ
T87	WTTVIERTFHVETPE
T92	ERTFHVETPEEREEW
T117-p	LKRQEEEtMDFRsGs
S122-p	EEtMDFRsGsPsDNs
S124-p	tMDFRsGsPsDNsGA
S126	DFRsGsPSDNsGAEE
S126-p	DFRsGsPsDNsGAEE
S129	sGsPsDNSGAEEMEV
S129-p	sGsPsDNsGAEEMEV
S137-p	GAEEMEVsLAKPKHR
T146	AKPKHRVTMNEFEYL
Y176-p	EKATGRYyAMKILKK
S246	LSRERVFSEDRARFY
K276-u	NVVYRDLkLENLMLD
T305	EGIKDGATMKtFCGt
T305-p	EGIKDGAtMKtFCGt
T308-p	KDGAtMKtFCGtPEy
T312	tMKtFCGTPEyLAPE
T312-p	tMKtFCGtPEyLAPE
Y315-p	tFCGtPEyLAPEVLE
Y326-p	EVLEDNDyGRAVDWW
K377	RTLGPEAKSLLSGLL
Y417	NIVWQDVYEKKLSPP
K420	WQDVYEKKLSPPFKP
K426	KKLSPPFKPQVTSET
Y437	TSETDTRYFDEEFTA
T450-p	TAQMITItPPDQDDS
S473-p	RPHFPQFsysASGtA
S473-gl	RPHFPQFsysASGtA
Y474-p	PHFPQFsysASGtA_
S475-p	HFPQFsysASGtA__
S477	PQFsysASGtA____
T479-p	FsysASGtA______

	rat
K8	MNDVAIVKEGWLHKR
K14	VKEGWLHKRGEYIKT
K30	RPRYFLLKNDGtFIG
T34-p	FLLKNDGtFIGYKER
T65	AQCQLMKTERPRPNT
T72	TERPRPNTFIIRCLQ
T87	WTTVIERTFHVETPE
T92	ERTFHVETPEEREEW
T117	LKRQEEETMDFRSGs
S122	EETMDFRSGsPSDNS
S124-p	TMDFRSGsPSDNSGA
S126	DFRSGsPSDNSGAEE
S126	DFRSGsPSDNSGAEE
S129	SGsPSDNSGAEEMEV
S129	SGsPSDNSGAEEMEV
A137	GAEEMEVALAKPKHR
T146	AKPKHRVTMNEFEYL
Y176	EKATGRYYAMKILKK
S246	LSRERVFSEDRARFY
K276	NVVYRDLKLENLMLD
T305	EGIKDGATMKtFCGT
T305	EGIKDGATMKtFCGT
T308-p	KDGATMKtFCGTPEY
T312	TMKtFCGTPEYLAPE
T312	TMKtFCGTPEYLAPE
Y315	tFCGTPEYLAPEVLE
Y326	EVLEDNDYGRAVDWW
K377	RTLGPEAKSLLSGLL
Y417	NIVWQDVYEKKLSPP
K420	WQDVYEKKLSPPFKP
K426	KKLSPPFKPQVTSET
Y437	TSETDTRYFDEEFTA
T450-p	TAQMITItPPDQDDS
S473-p	RPHFPQFsYSASGTA
S473-gl	RPHFPQFsYSASGTA
Y474	PHFPQFsYSASGTA_
S475	HFPQFsYSASGTA__
S477	PQFsYSASGTA____
T479	FsYSASGTA______

	cow
K8	MNDVAIVKEGWLHKR
K14	VKEGWLHKRGEYIKT
K30	RPRYFLLKNDGTFIG
T34	FLLKNDGTFIGYKER
T65	AQCQLMKTERPRPNT
T72	TERPRPNTFIIRCLQ
T87	WTTVIERTFHVETPE
T92	ERTFHVETPEEREEW
T117	LKRQEEETMDFRSGS
S122	EETMDFRSGSPGENS
S124	TMDFRSGSPGENSGA
G126	DFRSGSPGENSGAEE
G126	DFRSGSPGENSGAEE
S129	SGSPGENSGAEEMEV
S129	SGSPGENSGAEEMEV
S137	GAEEMEVSLAKPKHR
T146	AKPKHRVTMNDFEYL
Y176	EKATGRYYAMKILKK
S246	LSRERVFSEDRARFY
K276	EVVYRDLKLENLMLD
T305	EGIKDGATMKtFCGT
T305	EGIKDGATMKtFCGT
T308-p	KDGATMKtFCGTPEY
T312	TMKtFCGTPEYLAPE
T312	TMKtFCGTPEYLAPE
Y315	tFCGTPEYLAPEVLE
Y326	EVLEDNDYGRAVDWW
K377	RTLSPEAKSLLSGLL
Y417	SIVWQDVYEKKLSPP
K420	WQDVYEKKLSPPFKP
K426	KKLSPPFKPQVTSET
Y437	TSETDTRYFDEEFTA
T450	TAQMITITPPDQDDS
S473-p	RPHFPQFsYSASATA
S473	RPHFPQFSYSASATA
Y474	PHFPQFsYSASATA_
S475	HFPQFsYSASATA__
S477	PQFsYSASATA____
T479	FsYSASATA______

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