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Protein Page:
K1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K1 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: extracellular space; cytoskeleton; membrane; keratin filament; plasma membrane; nucleus
Molecular Function: protein binding; receptor activity; carbohydrate binding; structural molecule activity
Biological Process: retinal homeostasis; fibrinolysis; response to oxidative stress; complement activation, lectin pathway; regulation of angiogenesis
Reference #:  P04264 (UniProtKB)
Alt. Names/Synonyms: 67 kDa cytokeratin; CK-1; CK1; cytokeratin 1; Cytokeratin-1; EHK; EHK1; epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; K2C1; keratin 1; Keratin, type II cytoskeletal 1; Keratin-1; KRT1; KRT1A; KRTA; NEPPK; Type-II keratin Kb1
Gene Symbols: KRT1
Molecular weight: 66,039 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below

K1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R12 FSSRSGYRsGGGFSS
0 1 S13-p SSRSGYRsGGGFSSG
0 1 S18 YRsGGGFSSGsAGII
0 2 S19 RsGGGFSSGsAGIIN
0 11 S21-p GGGFSSGsAGIINyQ
0 9 Y27-p GsAGIINyQRRtTSS
0 2 T31-p IINyQRRtTSSSTRR
0 2 S33 NyQRRtTSSSTRRSG
0 2 S34 yQRRtTSSSTRRSGG
0 1 S35 QRRtTSSSTRRSGGG
0 1 R45 RSGGGGGRFsSCGGG
0 1 S47-p GGGGGRFsSCGGGGG
0 2 A58 GGGGSFGAGGGFGSR
0 1 G60 GGSFGAGGGFGSRsL
0 5 S66-p GGGFGSRsLVNLGGS
0 1 R82-m1 SISISVArGGGRGSG
0 1 G103 GGGFGGGGFGGGGFG
0 1 G117 GGGGIGGGGFGGFGS
0 18 S193-p SLNNQFAsFIDkVRF
0 6 K197-ac QFAsFIDkVRFLEQQ
0 10 K197-ub QFAsFIDkVRFLEQQ
0 2 K298-ac VDGAYMTkVDLQAKL
0 4 S344-p LSMDNNRsLDLDSII
0 57 Y358-p IAEVKAQyEDIAQKS
0 14 Y373-p KAEAESLyQSKyEEL
0 14 Y377-p ESLyQSKyEELQITA
0 1 S394-p HGDSVRNsKIEIsEL
0 1 S399-p RNsKIEIsELNRVIQ
0 1 S494-p EGEESRMsGECAPNV
0 1 S502-p GECAPNVsVSVStSH
0 1 T507-p NVsVSVStSHTTISG
0 1 S517-p TTISGGGsRGGGGGG
0 1 R518 TISGGGsRGGGGGGY
0 1 - gap
0 1 - gap
0 1 S530-p GGYGSGGsSyGsGGG
0 2 Y532-p YGSGGsSyGsGGGSy
0 1 S534-p SGGsSyGsGGGSyGS
0 3 Y539-p yGsGGGSyGSGGGGG
0 1 S551-p GGGGGRGsyGSGGSs
0 2 Y552-p GGGGRGsyGSGGSsY
0 1 S558-p syGSGGSsYGSGGGS
0 1 Y566-p YGSGGGSyGsGGGGG
0 1 S568-p SGGGSyGsGGGGGGH
0 1 Y578-p GGGGHGSyGSGSSSG
0 2 Y587-p SGSSSGGyRGGSGGG
0 1 R588 GSSSGGyRGGSGGGG
0 1 S591 SGGyRGGSGGGGGGs
0 1 S598-p SGGGGGGssGGRGSG
0 1 S599-p GGGGGGssGGRGSGG
0 2 S604 GssGGRGSGGGSSGG
0 1 - gap
0 1 S612-p GGGSSGGsIGGRGss
0 3 I613 GGSSGGsIGGRGssS
0 3 S618-p GsIGGRGssSGGVKS
0 1 S619-p sIGGRGssSGGVKSS
0 1 S636-p SSSVKFVsTtySGVT
0 1 T638-p SVKFVsTtySGVTR_
0 44 Y639-p VKFVsTtySGVTR__
0 1 G641 FVsTtySGVTR____
  mouse

 
R12-m1 CSSRSLCrGGGGSRN
G13 SSRSLCrGGGGSRNF
S21-p GGGSRNFssGsAGLV
S22-p GGSRNFssGsAGLVS
S24-p SRNFssGsAGLVSFQ
F30 GsAGLVSFQRRsTss
S34-p LVSFQRRsTsssMRR
S36-p SFQRRsTsssMRRSG
S37-p FQRRsTsssMRRSGG
S38-p QRRsTsssMRRSGGG
R49-m1 SGGGGGGrFsGGGFC
S51-p GGGGGrFsGGGFCGS
S59-p GGGFCGSsGsGFGSK
S61-p GFCGSsGsGFGSKsL
S67-p GsGFGSKsLMNLGGG
G83 SISKSVAGGGGSFCG
S106-p GGGFGGGsYGGGGFG
S125-p GGGGFGGsGFGGGLG
S201-p SLNDKFAsFIDkVRF
K205 KFAsFIDKVRFLEQQ
K205-ub KFAsFIDkVRFLEQQ
K306-ac VDSAYMTkVELQAKA
S352-p LSMDNNRsLDLDGII
Y366 ISEVKAQYDSICQRS
Y381 KAEAETFYQSKYEEL
Y385 ETFYQSKYEELQITA
T402 HGDSVRNTKMEISEL
S407 RNTKMEISELNRMIQ
S502 EGEEIRMSGECTPNV
S510 GECTPNVSVSVSTSH
T515 NVSVSVSTSHTSMSG
S525 TSMSGSSSrGGGsGG
R526-m1 SMSGSSSrGGGsGGG
S530-p SSSrGGGsGGGRyGG
S530-gl SSSrGGGsGGGRyGG
- gap
Y535-p GGsGGGRyGGGGSYG
- gap
Y541 RyGGGGSYGGGSGGG
S549 GGGSGGGSYGGSSGG
Y550 GGSGGGSYGGSSGGG
S559 GSSGGGGSGGSYGGG
Y563 GGGSGGSYGGGSGGG
S567 GGSYGGGSGGGSYGG
Y572 GGSGGGSYGGGSGGG
H584 GGGSSGSHrGGsGGG
R585-m1 GGSSGSHrGGsGGGG
S588-p SGSHrGGsGGGGGss
S594-p GsGGGGGssGGsyGG
S595-p sGGGGGssGGsyGGS
S598-p GGGssGGsyGGSSGG
Y599-p GGssGGsyGGSSGGG
G606 yGGSSGGGrGGsSSG
R607-m1 GGSSGGGrGGsSSGG
S610-p SGGGrGGsSSGGGGV
S611 GGGrGGsSSGGGGVK
S629 SSTVKFVSTSYSrGT
S631 TVKFVSTSYSrGTK_
Y632 VKFVSTSYSrGTK__
R634-m1 FVSTSYSrGTK____
  rat

 
R12 CSSRSLCRSGGGGGG
S13 SSRSLCRSGGGGGGR
S23 GGGGRNFSSGSAGLV
S24 GGGRNFSSGSAGLVS
S26 GRNFSSGSAGLVSFQ
F32 GSAGLVSFQRRSTSS
S36 LVSFQRRSTSSSMRR
S38 SFQRRSTSSSMRRSG
S39 FQRRSTSSSMRRSGG
S40 QRRSTSSSMRRSGGG
R51 SGGGGGGRFSGGGFC
S53 GGGGGRFSGGGFCGS
S61 GGGFCGSSGGGFGSK
G63 GFCGSSGGGFGSKSL
S69 GGGFGSKSLVNLGGG
G85 SISISVAGGGSSYGG
S108 GGSFGGGSFGGGVGG
G120 VGGGFGGGGFGGGGF
S192 SLNDKFASFIDKVRF
K196 KFASFIDKVRFLEQQ
K196 KFASFIDKVRFLEQQ
K297 VDSAYMNKAELQARV
T343 LSMDNNRTLDLDGII
Y357 IAEVKAQYDSICQRS
Y372 KAEAETFYQSKYEEL
Y376 ETFYQSKYEELQITA
T393 HGDSVKNTKMEISEL
S398 KNTKMEISELNRVIQ
S493 EGEEIRMSGECTPNV
S501 GECTPNVSVSVSTSH
T506 NVSVSVSTSHTSMSG
S516 TSMSGTSSRGGGRYG
R517 SMSGTSSRGGGRYGS
- gap
- gap
- gap
Y522 SSRGGGRYGSGGGGG
S524 RGGGRYGSGGGGGGG
Y533 GGGGGGTYGGGSRGG
S541 GGGSRGGSYGGGSGG
Y542 GGSRGGSYGGGSGGG
S550 GGGSGGGSYGGCSSG
Y551 GGSGGGSYGGCSSGG
S560 GCSSGGGSGGGSYGG
Y565 GGSGGGSYGGGSSGG
H573 GGGSSGGHRGGSGGG
R574 GGSSGGHRGGSGGGG
S577 SGGHRGGSGGGGGSS
S583 GSGGGGGSSGGSYGG
S584 SGGGGGSSGGSYGGS
S587 GGGSSGGSYGGSSGG
Y588 GGSSGGSYGGSSGGG
G595 YGGSSGGGRGGSSSG
R596 GGSSGGGRGGSSSGG
S599 SGGGRGGSSSGGGVK
S600 GGGRGGSSSGGGVKS
S617 SSSVKFVSTTYSRGT
T619 SVKFVSTTYSRGTN_
Y620 VKFVSTTYSRGTN__
R622 FVSTTYSRGTN____
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