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Protein Page:
K1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
K1 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: cytoskeleton; membrane; keratin filament; plasma membrane; intermediate filament
Molecular Function: protein binding; structural constituent of cytoskeleton; receptor activity; carbohydrate binding
Biological Process: epidermis development; fibrinolysis; response to oxidative stress; complement activation, lectin pathway; regulation of angiogenesis
Reference #:  P04264 (UniProtKB)
Alt. Names/Synonyms: 67 kDa cytokeratin; CK-1; CK1; cytokeratin 1; Cytokeratin-1; EHK; EHK1; epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; K2C1; keratin 1; Keratin, type II cytoskeletal 1; Keratin-1; KRT1; KRT1A; KRTA; NEPPK; Type-II keratin Kb1
Gene Symbols: KRT1
Molecular weight: 66,039 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below

K1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S13-p SSRSGYRsGGGFSSG
0 1 S18 YRsGGGFSSGsAGII
0 2 S19 RsGGGFSSGsAGIIN
0 11 S21-p GGGFSSGsAGIINyQ
0 9 Y27-p GsAGIINyQRRtTSS
0 2 T31-p IINyQRRtTSSSTRR
0 2 S33 NyQRRtTSSSTRRSG
0 2 S34 yQRRtTSSSTRRSGG
0 1 S35 QRRtTSSSTRRSGGG
0 1 S47 GGGGGRFSSCGGGGG
0 2 A58 GGGGSFGAGGGFGSR
0 1 G60 GGSFGAGGGFGSRsL
0 5 S66-p GGGFGSRsLVNLGGS
0 1 G103 GGGFGGGGFGGGGFG
0 1 F122 GGGGFGGFGSGGGGF
0 15 S193-p SLNNQFAsFIDkVRF
0 6 K197-a QFAsFIDkVRFLEQQ
0 10 K197-u QFAsFIDkVRFLEQQ
0 2 K298-a VDGAYMTkVDLQAKL
0 3 S344-p LSMDNNRsLDLDSII
0 58 Y358-p IAEVKAQyEDIAQKS
0 15 Y373-p KAEAESLyQSKyEEL
0 15 Y377-p ESLyQSKyEELQITA
0 1 S394-p HGDSVRNsKIEIsEL
0 1 S399-p RNsKIEIsELNRVIQ
0 1 S494-p EGEESRMsGECAPNV
0 1 S502-p GECAPNVsVSVStSH
0 1 T507-p NVsVSVStSHTTISG
0 1 S517-p TTISGGGsRGGGGGG
0 1 G522 GGsRGGGGGGYGSGG
0 1 G522 GGsRGGGGGGYGSGG
0 1 S530-p GGYGSGGsSyGsGGG
0 2 Y532-p YGSGGsSyGsGGGSy
0 1 S534-p SGGsSyGsGGGSyGS
0 3 Y539-p yGsGGGSyGSGGGGG
0 1 S551-p GGGGGRGsyGSGGSs
0 2 Y552-p GGGGRGsyGSGGSsY
0 1 S558-p syGSGGSsYGSGGGS
0 1 Y566-p YGSGGGSyGsGGGGG
0 1 S568-p SGGGSyGsGGGGGGH
0 1 Y578-p GGGGHGSyGSGSSSG
0 2 Y587-p SGSSSGGyRGGSGGG
0 1 S591 SGGyRGGSGGGGGGS
0 1 G597 GSGGGGGGSSGGRGS
0 1 S598 SGGGGGGSSGGRGSG
0 2 S604 GSSGGRGSGGGSSGG
0 1 - gap
0 1 S612-p GGGSSGGsIGGRGss
0 2 I613 GGSSGGsIGGRGssS
0 2 R616 SGGsIGGRGssSGGV
0 1 S618-p GsIGGRGssSGGVKS
0 1 S619-p sIGGRGssSGGVKSS
0 1 S636-p SSSVKFVsTtySGVT
0 1 T638-p SVKFVsTtySGVTR_
0 49 Y639-p VKFVsTtySGVTR__
  mouse

 
G13 SSRSLCRGGGGSRNF
S21-p GGGSRNFssGsAGLV
S22-p GGSRNFssGsAGLVS
S24-p SRNFssGsAGLVSFQ
F30 GsAGLVSFQRRsTss
S34-p LVSFQRRsTsssMRR
S36-p SFQRRsTsssMRRSG
S37-p FQRRsTsssMRRSGG
S38-p QRRsTsssMRRSGGG
S51-p GGGGGRFsGGGFCGS
S59-p GGGFCGSsGsGFGSK
S61-p GFCGSsGsGFGSKsL
S67-p GsGFGSKsLMNLGGG
S106-p GGGFGGGsYGGGGFG
S125-p GGGGFGGsGFGGGLG
S201-p SLNDKFAsFIDkVRF
K205 KFAsFIDKVRFLEQQ
K205-u KFAsFIDkVRFLEQQ
K306-a VDSAYMTkVELQAKA
S352-p LSMDNNRsLDLDGII
Y366 ISEVKAQYDSICQRS
Y381 KAEAETFYQSKYEEL
Y385 ETFYQSKYEELQITA
T402 HGDSVRNTKMEISEL
S407 RNTKMEISELNRMIQ
S502 EGEEIRMSGECTPNV
S510 GECTPNVSVSVSTSH
T515 NVSVSVSTSHTSMSG
S525 TSMSGSSSRGGGsGG
S530-p SSSRGGGsGGGRyGG
S530-g SSSRGGGsGGGRyGG
G533 RGGGsGGGRyGGGGS
Y535-p GGsGGGRyGGGGSYG
- gap
Y541 RyGGGGSYGGGSGGG
S549 GGGSGGGSYGGSSGG
Y550 GGSGGGSYGGSSGGG
S559 GSSGGGGSGGSYGGG
Y563 GGGSGGSYGGGSGGG
S567 GGSYGGGSGGGSYGG
G575 GGGSYGGGSGGGSSG
H584 GGGSSGSHRGGsGGG
S588-p SGSHRGGsGGGGGss
S594-p GsGGGGGssGGsyGG
S595-p sGGGGGssGGsyGGS
S598-p GGGssGGsyGGSSGG
Y599-p GGssGGsyGGSSGGG
G606 yGGSSGGGrGGsSSG
R607-m1 GGSSGGGrGGsSSGG
S610-p SGGGrGGsSSGGGGV
S612 GGrGGsSSGGGGVKS
G613 GrGGsSSGGGGVKSS
S629 SSTVKFVSTSYSRGT
S631 TVKFVSTSYSRGTK_
Y632 VKFVSTSYSRGTK__
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