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PIP4K2B (human)

Overview PIP4K2B Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis; EC 2.7.1.149; Carbohydrate Metabolism - inositol phosphate Cellular Component: endoplasmic reticulum membrane; plasma membrane; nucleus; cytosol Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; receptor signaling protein activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding Biological Process: cell surface receptor linked signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process Reference #:  P78356 (UniProtKB) Alt. Names/Synonyms: 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; Phosphatidylinositol-5-phosphate 4-kinase type II beta; Phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI(5)P 4-kinase type II beta; PI42B; PI5P4KB; PIP4K2B; PIP4KII-beta; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PTDINS(4)P-5-kinase; PtdIns(5)P-4-kinase isoform 2-beta Gene Symbols: PIP4K2B Molecular weight: 47,378 Da Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states CST Pathways:  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PIP4K2B 1BO1 - A/B=1-416 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME 2.7.1.149 2.7.1.68  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: S326‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S7	_MSSNCTSTTAVAVA
0	1		T8	MSSNCTSTTAVAVAP
0	1		T9	SSNCTSTTAVAVAPL
0	33		Y98-p	SRFKFKEyCPMVFRN
0	2		S124-p	YQNSVTRsAPINSDS
0	2		K150-a	YDRRFVIkTVSSEDV
0	2		Y167-p	MHNILKKyHQFIVEC
0	1		T196-p	LTVDGVEtyMVVTRN
0	2		Y197-p	TVDGVEtyMVVTRNV
0	1		S256-p	KLHVGEEsKKNFLEK
0	1		S319	VGGNLLCSYGtPPDs
0	1		Y320	GGNLLCSYGtPPDsP
0	27		T322-p	NLLCSYGtPPDsPGN
1	19		S326-p	SYGtPPDsPGNLLsF
0	1		S332-p	DsPGNLLsFPRFFGP
0	1		Y363-p	SSPKKEVyFMAIIDI
0	1		K385-a	KKAAHAAkTVKHGAG

	mouse
S7-p	_MSSNCTsttAVAVA
T8-p	MSSNCTsttAVAVAP
T9-p	SSNCTsttAVAVAPL
Y98-p	SRFKFKEyCPMVFRN
S124	YQNSVTRSAPINSDS
K150	YDRRFVIKTVSSEDV
Y167	MHNILKKYHQFIVEC
T196	LTVDGVETYMVVTRN
Y197	TVDGVETYMVVTRNV
S256	KLHVGEESKKNFLEK
S319-p	VGGSLLCsyGtPPDs
Y320-p	GGSLLCsyGtPPDsP
T322-p	SLLCsyGtPPDsPGN
S326-p	syGtPPDsPGNLLsF
S332-p	DsPGNLLsFPRFFGP
Y363	SAPKKEVYFMAIIDI
K385	KKAAHAAKTVKHGAG

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