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Protein Page:
PIP4K2B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIP4K2B Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, lipid; EC 2.7.1.68; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149
Cellular Component: endoplasmic reticulum membrane; plasma membrane; cytosol; nucleus
Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; receptor signaling protein activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding
Biological Process: cell surface receptor linked signal transduction; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process
Reference #:  P78356 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; Phosphatidylinositol-5-phosphate 4-kinase type II beta; Phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI(5)P 4-kinase type II beta; PI42B; PI5P4KB; PIP4K2B; PIP4KII-beta; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PTDINS(4)P-5-kinase; PtdIns(5)P-4-kinase isoform 2-beta
Gene Symbols: PIP4K2B
Molecular weight: 47,378 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIP4K2B

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: S326‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7 _MSSNCTSTTAVAVA
0 1 T8 MSSNCTSTTAVAVAP
0 1 T9 SSNCTSTTAVAVAPL
0 33 Y98-p SRFKFKEyCPMVFRN
0 2 S124-p YQNSVTRsAPINSDS
0 3 K150-ac YDRRFVIkTVSSEDV
0 2 Y167-p MHNILKKyHQFIVEC
0 1 T196-p LTVDGVEtyMVVTRN
0 2 Y197-p TVDGVEtyMVVTRNV
0 1 S256-p KLHVGEEsKKNFLEK
0 1 S319-p VGGNLLCsyGtPPDs
0 1 Y320-p GGNLLCsyGtPPDsP
0 27 T322-p NLLCsyGtPPDsPGN
1 19 S326-p syGtPPDsPGNLLSF
0 1 S332 DsPGNLLSFPRFFGP
0 1 Y363-p SSPKKEVyFMAIIDI
0 1 K385-ac KKAAHAAkTVKHGAG
  mouse

 
S7-p _MSSNCTsttAVAVA
T8-p MSSNCTsttAVAVAP
T9-p SSNCTsttAVAVAPL
Y98-p SRFKFKEyCPMVFRN
S124 YQNSVTRSAPINSDS
K150 YDRRFVIKTVSSEDV
Y167 MHNILKKYHQFIVEC
T196 LTVDGVETYMVVTRN
Y197 TVDGVETYMVVTRNV
S256 KLHVGEESKKNFLEK
S319-p VGGSLLCsyGtPPDs
Y320-p GGSLLCsyGtPPDsP
T322-p SLLCsyGtPPDsPGN
S326-p syGtPPDsPGNLLsF
S332-p DsPGNLLsFPRFFGP
Y363 SAPKKEVYFMAIIDI
K385 KKAAHAAKTVKHGAG
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