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GYS1 (human)

Overview GYS1 muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation. Note: This description may include information from UniProtKB. Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase Cellular Component: inclusion body; cytosol Molecular Function: protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process Reference #:  P13807 (UniProtKB) Alt. Names/Synonyms: Glycogen [starch] synthase, muscle; glycogen synthase 1 (muscle); GSY; GYS; GYS1 Gene Symbols: GYS1 Molecular weight: 83,786 Da Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GYS1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 138570 611556  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: S8‑p, S11‑p, S641‑p, S645‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T6-p	__MPLNRtLsMssLP
15	1		S8-p	MPLNRtLsMssLPGL
1	1		S10-p	LNRtLsMssLPGLED
9	2		S11-p	NRtLsMssLPGLEDW
0	27		Y44-p	ANKVGGIyTVLQTKA
0	1		K52-u	TVLQTKAkVTGDEWG
0	2		K88-a	EAPTPALkRTLDSMN
0	1		K88-u	EAPTPALkRTLDSMN
0	1		K97-a	TLDSMNSkGCkVyFG
0	1		K100-a	SMNSkGCkVyFGRWL
0	10		Y102-p	NSkGCkVyFGRWLIE
0	5		Y212	HATLLGRYLCAGAVD
0	3		K381-u	NFNVETLkGQAVRKQ
0	1		K397-u	WDTANTVkEKFGRKL
0	10		Y405-p	EKFGRKLyESLLVGs
0	3		S412-p	yESLLVGsLPDMNKM
0	1		S439	IFATQRQSFPPVCTH
0	4		K599-u	LSDLLDWkYLGRyYM
0	1		Y604-p	DWkYLGRyYMSARHM
0	1		K615-u	ARHMALSkAFPEHFT
0	1		Y636	DAAQGYRYPRPAsVP
26	12		S641-p	YRYPRPAsVPPsPsL
20	18		S645-p	RPAsVPPsPsLsRHs
0	3		S647-p	AsVPPsPsLsRHssP
13	6		S649-p	VPPsPsLsRHssPHQ
0	2		S652-p	sPsLsRHssPHQsED
12	8		S653-p	PsLsRHssPHQsEDE
13	19		S657-p	RHssPHQsEDEEDPR
0	3		G672	NGPLEEDGERyDEDE
0	6		Y675-p	LEEDGERyDEDEEAA
0	1		K683	DEDEEAAKDRRNIRA
1	8		S698-p	PEWPRRAsCTSSTSG
0	2		-	gap
2	6		S710-p	TSGSKRNsVDtAtss
0	2		T713-p	SKRNsVDtAtsssLS
0	1		T715-p	RNsVDtAtsssLStP
0	1		S716-p	NsVDtAtsssLStPS
0	2		S717-p	sVDtAtsssLStPSE
0	1		S718-p	VDtAtsssLStPSEP
1	2		T721-p	AtsssLStPSEPLsP
0	1		S723	sssLStPSEPLsPTS
1	6		S727-p	StPSEPLsPTSsLGE
0	1		T729	PSEPLsPTSsLGEER
0	1		S730	SEPLsPTSsLGEERN
0	2		S731-p	EPLsPTSsLGEERN_

	mouse
S6	__MPLSRSLsVssLP
S8-p	MPLSRSLsVssLPGL
S10-p	LSRSLsVssLPGLED
S11-p	SRSLsVssLPGLEDW
Y44-p	ANKVGGIyTVLQTKA
K52	TVLQTKAKVTGDEWG
K88	EPPTPELKRTLDSMN
K88	EPPTPELKRTLDSMN
K97	TLDSMNSKGCKVYFG
K100	SMNSKGCKVYFGRWL
Y102	NSKGCKVYFGRWLIE
Y212	HATLLGRYLCAGAVD
K381-u	NFNVETLkGQAVRKQ
K397	WDTANTVKEKFGRKL
Y405	EKFGRKLYESLLVGs
S412-p	YESLLVGsLPDMNKM
S439-p	IFATQRQsFPPVCTH
K599-u	LSDLLDWkYLGRYYM
Y604	DWkYLGRYYMSARHM
K615	ARHMALAKAFPDHFT
Y636-p	DATQGYRyPRPAsVP
S641-p	YRyPRPAsVPPsPsL
S645-p	RPAsVPPsPsLsRHs
S647-p	AsVPPsPsLsRHssP
S649-p	VPPsPsLsRHssPHQ
S652-p	sPsLsRHssPHQsED
S653-p	PsLsRHssPHQsEDE
S657-p	RHssPHQsEDEEEPR
S672-p	DGPLGEDsERYDEEE
Y675	LGEDsERYDEEEEAA
K683-u	DEEEEAAkDRRNIRA
S698-p	PEWPRRAsCSSSTGG
S709-p	STGGSKRsNsVDtGP
S711-p	GGSKRsNsVDtGPss
T714-p	KRsNsVDtGPsssLS
P716	sNsVDtGPsssLStP
S717-p	NsVDtGPsssLStPt
S718-p	sVDtGPsssLStPtE
S719-p	VDtGPsssLStPtEP
T722-p	GPsssLStPtEPLsP
T724-p	sssLStPtEPLsPts
S728-p	StPtEPLsPtssLGE
T730-p	PtEPLsPtssLGEER
S731-p	tEPLsPtssLGEERN
S732-p	EPLsPtssLGEERN_

	rat
S6	__MPLSRSLsMSsLP
S8-p	MPLSRSLsMSsLPGL
S10	LSRSLsMSsLPGLED
S11-p	SRSLsMSsLPGLEDW
Y44-p	ANKVGGIyTVLQTKA
K52	TVLQTKAKVTGDEWG
K88	EPPTPELKRTLDSMN
K88	EPPTPELKRTLDSMN
K97	TLDSMNSKGCKVYFG
K100	SMNSKGCKVYFGRWL
Y102	NSKGCKVYFGRWLIE
Y212-p	HATLLGRyLCAGAVD
K381	NFNVETLKGQAVRKQ
K397	WDTANTVKEKFGRKL
Y405	EKFGRKLYESLLVGS
S412	YESLLVGSLPDMNKM
S439	IFATQRQSFPPVCTH
K599	LSDLLDWKYLGRYYM
Y604	DWKYLGRYYMSARHM
K615	ARHMALAKAFPDHFT
Y636	DATQGYRYPRPAsVP
S641-p	YRYPRPAsVPPsPSL
S645-p	RPAsVPPsPSLsRHS
S647	AsVPPsPSLsRHSsP
S649-p	VPPsPSLsRHSsPHQ
S652	sPSLsRHSsPHQsED
S653-p	PSLsRHSsPHQsEDE
S657-p	RHSsPHQsEDEEEPR
S672	DGPLREDSERYDEEE
Y675	LREDSERYDEEEEAA
K683	DEEEEAAKDRRNIRA
S698	PEWPRRASCSSSTGG
S709	STGGSKRSNsVDTGP
S711-p	GGSKRSNsVDTGPSS
T714	KRSNsVDTGPSSSLS
P716	SNsVDTGPSSSLSTP
S717	NsVDTGPSSSLSTPT
S718	sVDTGPSSSLSTPTE
S719	VDTGPSSSLSTPTEP
T722	GPSSSLSTPTEPLSP
T724	SSSLSTPTEPLSPTS
S728	STPTEPLSPTSSLGE
T730	PTEPLSPTSSLGEER
S731	TEPLSPTSSLGEERN
S732	EPLSPTSSLGEERN_

	rabbit
T6	__MPLSRTLsVSsLP
S8-p	MPLSRTLsVSsLPGL
S10	LSRTLsVSsLPGLED
S11-p	SRTLsVSsLPGLEDW
Y44	ANKVGGIYTVLQTKA
K52	TVLQTKAKVTGDEWG
K88	EPPTPALKRTLDSMN
K88	EPPTPALKRTLDSMN
K97	TLDSMNSKGCKVYFG
K100	SMNSKGCKVYFGRWL
Y102	NSKGCKVYFGRWLIE
Y212	HATLLGRYLCAGAVD
K381	NFNVETLKGQAVRKQ
K397	WDTANTVKEKFGRKL
Y405	EKFGRKLYESLLVGS
S412	YESLLVGSLPDMNKM
S439	IFATQRQSFPPVCTH
K599	LSDLLDWKYLGRYYM
Y604	DWKYLGRYYMSARHM
K615	ARHMALAKAFPDHFT
Y636	DATQGYRYPRPAsVP
S641-p	YRYPRPAsVPPsPSL
S645-p	RPAsVPPsPSLsRHS
S647	AsVPPsPSLsRHSsP
S649-p	VPPsPSLsRHSsPHQ
S652	sPSLsRHSsPHQsED
S653-p	PSLsRHSsPHQsEDE
S657-p	RHSsPHQsEDEEEPR
G672	DGLPEEDGERYDEDE
Y675	PEEDGERYDEDEEAA
K683	DEDEEAAKDRRNIRA
S698	PEWPRRASCTSSSGG
S709	SSGGSKRSNsVDTSS
S711-p	GGSKRSNsVDTSSLS
T714	KRSNsVDTSSLSTPS
-	gap
-	gap
S715	RSNsVDTSSLSTPSE
S716	SNsVDTSSLSTPSEP
T719	VDTSSLSTPSEPLSP
S721	TSSLSTPSEPLSPAS
S725	STPSEPLSPASSLGE
A727	PSEPLSPASSLGEER
S728	SEPLSPASSLGEERN
S729	EPLSPASSLGEERN_

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