Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
GYS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GYS1 muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.11; Carbohydrate Metabolism - starch and sucrose; Transferase
Cellular Component: membrane; inclusion body; cytosol
Molecular Function: protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding
Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process
Reference #:  P13807 (UniProtKB)
Alt. Names/Synonyms: Glycogen [starch] synthase, muscle; glycogen synthase 1 (muscle); GSY; GYS; GYS1
Gene Symbols: GYS1
Molecular weight: 83,786 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GYS1

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, inhibited: S8‑p, S11‑p, S641‑p, S645‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6-p __MPLNRtLsMssLP
15 1 S8-p MPLNRtLsMssLPGL
1 1 S10-p LNRtLsMssLPGLED
9 3 S11-p NRtLsMssLPGLEDW
0 27 Y44-p ANKVGGIyTVLQTKA
0 1 K52-ub TVLQTKAkVTGDEWG
0 2 K88-ac EAPTPALkRTLDSMN
0 1 K88-ub EAPTPALkRTLDSMN
0 1 K97-ac TLDSMNSkGCkVyFG
0 1 K100-ac SMNSkGCkVyFGRWL
0 12 Y102-p NSkGCkVyFGRWLIE
0 5 Y212 HATLLGRYLCAGAVD
0 3 K381-ub NFNVETLkGQAVRKQ
0 1 K397-ub WDTANTVkEKFGRKL
0 9 Y405-p EKFGRKLyESLLVGs
0 7 S412-p yESLLVGsLPDMNKM
0 1 S439 IFATQRQSFPPVCTH
0 4 K599-ub LSDLLDWkYLGRyYM
0 1 Y604-p DWkYLGRyYMSARHM
0 1 K615-ub ARHMALSkAFPEHFT
0 2 Y636-p DAAQGYRyPRPAsVP
30 15 S641-p YRyPRPAsVPPsPsL
21 21 S645-p RPAsVPPsPsLsRHs
0 4 S647-p AsVPPsPsLsRHssP
14 9 S649-p VPPsPsLsRHssPHQ
0 10 S652-p sPsLsRHssPHQsED
13 14 S653-p PsLsRHssPHQsEDE
14 34 S657-p RHssPHQsEDEEDPR
0 3 G672 NGPLEEDGERyDEDE
0 5 Y675-p LEEDGERyDEDEEAA
0 1 K683 DEDEEAAKDRRNIRA
1 10 S698-p PEWPRRAsCtSSTSG
0 1 T700-p WPRRAsCtSSTSGSK
0 2 - gap
2 8 S710-p TSGSKRNsVDtAtss
0 2 T713-p SKRNsVDtAtsssLS
0 1 T715-p RNsVDtAtsssLStP
0 2 S716-p NsVDtAtsssLStPs
0 2 S717-p sVDtAtsssLStPsE
0 1 S718-p VDtAtsssLStPsEP
1 3 T721-p AtsssLStPsEPLsP
0 2 S723-p sssLStPsEPLsPts
1 10 S727-p StPsEPLsPtssLGE
0 2 T729-p PsEPLsPtssLGEER
0 2 S730-p sEPLsPtssLGEERN
0 4 S731-p EPLsPtssLGEERN_
  mouse

 
S6 __MPLSRSLsVssLP
S8-p MPLSRSLsVssLPGL
S10-p LSRSLsVssLPGLED
S11-p SRSLsVssLPGLEDW
Y44-p ANKVGGIyTVLQTKA
K52 TVLQTKAKVTGDEWG
K88 EPPTPELKRTLDSMN
K88 EPPTPELKRTLDSMN
K97 TLDSMNSKGCKVYFG
K100 SMNSKGCKVYFGRWL
Y102 NSKGCKVYFGRWLIE
Y212 HATLLGRYLCAGAVD
K381-ub NFNVETLkGQAVRKQ
K397 WDTANTVKEKFGRKL
Y405 EKFGRKLYESLLVGs
S412-p YESLLVGsLPDMNKM
S439-p IFATQRQsFPPVCTH
K599-ub LSDLLDWkYLGRYYM
Y604 DWkYLGRYYMSARHM
K615 ARHMALAKAFPDHFT
Y636-p DATQGYRyPRPAsVP
S641-p YRyPRPAsVPPsPsL
S645-p RPAsVPPsPsLsRHs
S647-p AsVPPsPsLsRHssP
S649-p VPPsPsLsRHssPHQ
S652-p sPsLsRHssPHQsED
S653-p PsLsRHssPHQsEDE
S657-p RHssPHQsEDEEEPR
S672-p DGPLGEDsERYDEEE
Y675 LGEDsERYDEEEEAA
K683-ub DEEEEAAkDRRNIRA
S698-p PEWPRRAsCSSSTGG
S700 WPRRAsCSSSTGGSK
S709-p STGGSKRsNsVDtGP
S711-p GGSKRsNsVDtGPss
T714-p KRsNsVDtGPsssLS
P716 sNsVDtGPsssLStP
S717-p NsVDtGPsssLStPt
S718-p sVDtGPsssLStPtE
S719-p VDtGPsssLStPtEP
T722-p GPsssLStPtEPLsP
T724-p sssLStPtEPLsPts
S728-p StPtEPLsPtssLGE
T730-p PtEPLsPtssLGEER
S731-p tEPLsPtssLGEERN
S732-p EPLsPtssLGEERN_
3891 : Phospho-Glycogen Synthase (Ser641) Antibody
  rat

 
S6 __MPLSRSLsMSsLP
S8-p MPLSRSLsMSsLPGL
S10 LSRSLsMSsLPGLED
S11-p SRSLsMSsLPGLEDW
Y44-p ANKVGGIyTVLQTKA
K52 TVLQTKAKVTGDEWG
K88 EPPTPELKRTLDSMN
K88 EPPTPELKRTLDSMN
K97 TLDSMNSKGCKVYFG
K100 SMNSKGCKVYFGRWL
Y102 NSKGCKVYFGRWLIE
Y212-p HATLLGRyLCAGAVD
K381 NFNVETLKGQAVRKQ
K397 WDTANTVKEKFGRKL
Y405 EKFGRKLYESLLVGS
S412 YESLLVGSLPDMNKM
S439 IFATQRQSFPPVCTH
K599 LSDLLDWKYLGRYYM
Y604 DWKYLGRYYMSARHM
K615 ARHMALAKAFPDHFT
Y636 DATQGYRYPRPAsVP
S641-p YRYPRPAsVPPsPSL
S645-p RPAsVPPsPSLsRHS
S647 AsVPPsPSLsRHSsP
S649-p VPPsPSLsRHSsPHQ
S652 sPSLsRHSsPHQsED
S653-p PSLsRHSsPHQsEDE
S657-p RHSsPHQsEDEEEPR
S672 DGPLREDSERYDEEE
Y675 LREDSERYDEEEEAA
K683 DEEEEAAKDRRNIRA
S698 PEWPRRASCSSSTGG
S700 WPRRASCSSSTGGSK
S709 STGGSKRSNsVDTGP
S711-p GGSKRSNsVDTGPSS
T714 KRSNsVDTGPSSSLS
P716 SNsVDTGPSSSLSTP
S717 NsVDTGPSSSLSTPT
S718 sVDTGPSSSLSTPTE
S719 VDTGPSSSLSTPTEP
T722 GPSSSLSTPTEPLSP
T724 SSSLSTPTEPLSPTS
S728 STPTEPLSPTSSLGE
T730 PTEPLSPTSSLGEER
S731 TEPLSPTSSLGEERN
S732 EPLSPTSSLGEERN_
  rabbit

 
T6 __MPLSRTLsVSsLP
S8-p MPLSRTLsVSsLPGL
S10 LSRTLsVSsLPGLED
S11-p SRTLsVSsLPGLEDW
Y44 ANKVGGIYTVLQTKA
K52 TVLQTKAKVTGDEWG
K88 EPPTPALKRTLDSMN
K88 EPPTPALKRTLDSMN
K97 TLDSMNSKGCKVYFG
K100 SMNSKGCKVYFGRWL
Y102 NSKGCKVYFGRWLIE
Y212 HATLLGRYLCAGAVD
K381 NFNVETLKGQAVRKQ
K397 WDTANTVKEKFGRKL
Y405 EKFGRKLYESLLVGS
S412 YESLLVGSLPDMNKM
S439 IFATQRQSFPPVCTH
K599 LSDLLDWKYLGRYYM
Y604 DWKYLGRYYMSARHM
K615 ARHMALAKAFPDHFT
Y636 DATQGYRYPRPAsVP
S641-p YRYPRPAsVPPsPSL
S645-p RPAsVPPsPSLsRHS
S647 AsVPPsPSLsRHSsP
S649-p VPPsPSLsRHSsPHQ
S652 sPSLsRHSsPHQsED
S653-p PSLsRHSsPHQsEDE
S657-p RHSsPHQsEDEEEPR
G672 DGLPEEDGERYDEDE
Y675 PEEDGERYDEDEEAA
K683 DEDEEAAKDRRNIRA
S698 PEWPRRASCTSSSGG
T700 WPRRASCTSSSGGSK
S709 SSGGSKRSNsVDTSS
S711-p GGSKRSNsVDTSSLS
T714 KRSNsVDTSSLSTPS
- gap
- gap
S715 RSNsVDTSSLSTPSE
S716 SNsVDTSSLSTPSEP
T719 VDTSSLSTPSEPLSP
S721 TSSLSTPSEPLSPAS
S725 STPSEPLSPASSLGE
A727 PSEPLSPASSLGEER
S728 SEPLSPASSLGEERN
S729 EPLSPASSLGEERN_
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.