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Protein Page:
TNFRSF8 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TNFRSF8 Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Cellular Component: cytoplasm; plasma membrane; integral to membrane
Molecular Function: tumor necrosis factor receptor activity; transmembrane receptor activity
Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; tumor necrosis factor-mediated signaling pathway; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction
Reference #:  P28908 (UniProtKB)
Alt. Names/Synonyms: CD30; CD30 antigen; CD30L receptor; cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; TNR8; Tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8
Gene Symbols: TNFRSF8
Molecular weight: 63,747 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Select Structure to View Below

TNFRSF8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S206-ga RLAQEAAsKLtRAPD
0 1 T209-ga QEAAsKLtRAPDSPS
0 1 S438-p PKLELVDsRPRRsst
0 10 S443-p VDsRPRRsstQLRsG
0 34 S444-p DsRPRRsstQLRsGA
0 22 T445-p sRPRRsstQLRsGAs
0 6 S449-p RsstQLRsGAsVtEP
0 18 S452-p tQLRsGAsVtEPVAE
0 1 T454-p LRsGAsVtEPVAEER
0 5 Y479-p CHSVGAAyLESLPLQ
0 1 S496-p SPAGGPSsPRDLPEP
0 9 Y518-p NNKIEKIyIMKADTV
  mouse

 
- under review  
- under review  
S339 PKMEQTDSCPTEKLT
K344 TDSCPTEKLTQPQRs
L345 DSCPTEKLTQPQRsG
T346 SCPTEKLTQPQRsGs
S351-p KLTQPQRsGsVTDPS
S353-p TQPQRsGsVTDPSTG
T355 PQRsGsVTDPSTGHK
Y382 CASVGATYLENLPLL
S399 SPAGNPFSPREPPEP
Y421 NNRIEKIYIMKADTV
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