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TNFRSF8 (human)

Overview TNFRSF8 Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, misc. Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; tumor necrosis factor-mediated signaling pathway; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction; activation of NF-kappaB transcription factor Reference #:  P28908 (UniProtKB) Alt. Names/Synonyms: CD30; CD30 antigen; CD30L receptor; cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; TNR8; Tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8 Gene Symbols: TNFRSF8 Molecular weight: 63,747 Da Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states CST Pathways:  PI3K/Akt Signaling

Select Structure to View Below TNFRSF8 1D01 - G/H/I=576-583 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S222	PSSVGRPSSDPGLSP
0	10		S443-p	VDSRPRRsstQLRsG
0	34		S444-p	DSRPRRsstQLRsGA
0	22		T445-p	SRPRRsstQLRsGAs
0	6		S449-p	RsstQLRsGAsVtEP
0	17		S452-p	tQLRsGAsVtEPVAE
0	1		T454-p	LRsGAsVtEPVAEER
0	5		Y479-p	CHSVGAAyLESLPLQ
0	1		S496-p	SPAGGPSsPRDLPEP
0	9		Y518-p	NNKIEKIyIMKADTV
0	1		Y560-p	EADHTPHyPEQETEP

	mouse
S220-p	SSKAREPsPDPGNAE
K344	TDSCPTEKLTQPQRs
L345	DSCPTEKLTQPQRsG
T346	SCPTEKLTQPQRsGs
S351-p	KLTQPQRsGsVTDPS
S353-p	TQPQRsGsVTDPSTG
T355	PQRsGsVTDPSTGHK
Y382	CASVGATYLENLPLL
S399	SPAGNPFSPREPPEP
Y421	NNRIEKIYIMKADTV
Y463	EVDHAPHYPEQETEP

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