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Protein Page:
LAMA1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LAMA1 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Extracellular matrix
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction
Molecular Function: protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding
Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration
Reference #:  P25391 (UniProtKB)
Alt. Names/Synonyms: LAMA; LAMA1; Laminin A chain; Laminin subunit alpha-1; laminin, alpha 1; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-LAM alpha; S-laminin subunit alpha
Gene Symbols: LAMA1
Molecular weight: 337,084 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below

LAMA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y337-p HNKAKDCyYDESVAK
0 4 K486-a GKACDRCkPGFYNLK
0 1 T581-p AYLGNKLtAFGGFLK
0 2 K1953 QRSSRFLKEGNNLSR
0 1 S2474-p TFDLLRNsyGVRkGC
0 1 Y2475-p FDLLRNsyGVRkGCL
0 1 K2479-m1 RNsyGVRkGCLLEPI
0 1 S2508 PKSLSPESEWLVTFA
0 1 E2509 KSLSPESEWLVTFAT
0 1 T2516 EWLVTFATTNSSGII
0 1 Y2753 FASSGLIYYMAHQNQ
0 1 Y2754 ASSGLIYYMAHQNQA
  mouse

 
Y344 HNKAKDCYYDSSVAK
K493-a GKNCDRCkPGFYNLK
T588 AYLGNKLTAFGGFLK
K1961-a QRSSRFLkESVGTRR
S2482 TFDLLRNSYGVRKGC
Y2483 FDLLRNSYGVRKGCA
K2487 RNSYGVRKGCALEPI
S2516-p PKSLSPEssLLATFA
S2517-p KSLSPEssLLATFAt
T2524-p sLLATFAtKNSSGIL
Y2762-p FASSGLIyyVAHQNQ
Y2763-p ASSGLIyyVAHQNQM
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