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FOXC1 (human)

Overview FOXC1 Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Cell development/differentiation; DNA binding protein; Cell cycle regulation Cellular Component: transcription factor complex; cytoplasm; nucleolus; nuclear heterochromatin; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; chromatin DNA binding; double-stranded DNA binding; transcription factor binding; DNA bending activity; transcription factor activity Biological Process: collagen fibril organization; glycosaminoglycan metabolic process; neural crest cell development; positive regulation of transcription, DNA-dependent; heart development; cardiac muscle cell proliferation; regulation of transcription, DNA-dependent; ovarian follicle development; regulation of transcription factor activity; ureteric bud development; germ cell migration; lymphangiogenesis; ventricular cardiac muscle morphogenesis; negative regulation of mitotic cell cycle; lacrimal gland development; regulation of blood vessel size; vasculogenesis; skeletal development; somitogenesis; ossification; Notch signaling pathway; camera-type eye development; in utero embryonic development; regulation of organ growth; odontogenesis of dentine-containing teeth; paraxial mesodermal cell fate commitment; eye development; artery morphogenesis; embryonic heart tube development; neural crest cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; brain development; vascular endothelial growth factor receptor signaling pathway; metanephros development Reference #:  Q12948 (UniProtKB) Alt. Names/Synonyms: ARA; FKHL7; forkhead box C1; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3 Gene Symbols: FOXC1 Molecular weight: 56,789 Da Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXC1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 601090 601631 602482  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S272‑p activation: S272‑p protein stabilization: S272‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S12-p	YSVSSPNsLGVVPYL
0	1		Y37	AAAAGGGYTAMPAPM
0	1		T38	AAAGGGYTAMPAPMS
1	9		T68-p	ARAYGPYtPQPQPKD
0	1		K181	FKKKDAVKDKEEKDR
0	2		T228-p	VRIQDIKtENGtCPs
0	2		T232-p	DIKtENGtCPsPPQP
0	7		S235-p	tENGtCPsPPQPLsP
0	7		S241-p	PsPPQPLsPAAALGS
0	1		S248	sPAAALGSGSAAAVP
1	0		S272-p	SSLSSGSsPPGSLPS
0	3		S320-p	IMTSLRGsPQSAAAE
0	1		S521-p	QRIGLNNsPVNGNSS

	mouse
S12	YSVSSPNSLGVVPYL
Y37-p	AAAAGGGytAMPAPM
T38-p	AAAGGGytAMPAPMS
T68-p	ARAYGPYtPQPQPKD
K181-a	FKKKDAVkDKEEKGR
T230-p	VRIQDIKtENGtCPs
T234-p	DIKtENGtCPsPPQP
S237-p	tENGtCPsPPQPLsP
S243-p	PsPPQPLsPAAALGs
S250-p	sPAAALGsGSAATVP
S274	SSLSSGSSPPGSLPS
S320-p	IMTSLRGsPQGSAAE
S521	QRIGLNNSPVNGNSS

	rat
S12	YSVSSPNSLGVVPYL
Y37	AAAAGGGYTAMPAPM
T38	AAAGGGYTAMPAPMS
T68	ARAYGPYTPQPQPKD
K181	FKKKDAVKDKEEKGR
T230	VRIQDIKTENGTCPS
T234	DIKTENGTCPSPPQP
S237	TENGTCPSPPQPLSP
S243	PSPPQPLSPAAALGS
S250	SPAAALGSGSAATVP
S274	SSLSSGSSPPGSLPS
S320	IMTSLRGSPQGSAAE
S521	QRIGLNNSPVNGNSS

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