Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
FOXC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXC1 Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA binding protein; Transcription factor
Cellular Component: cytoplasm; nucleolus; nuclear heterochromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; DNA bending activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; collagen fibril organization; neural crest cell development; glycosaminoglycan metabolic process; paraxial mesoderm formation; positive regulation of transcription, DNA-dependent; heart development; cardiac muscle cell proliferation; ovarian follicle development; regulation of transcription, DNA-dependent; ureteric bud development; germ cell migration; ventricular cardiac muscle morphogenesis; negative regulation of mitotic cell cycle; lacrimal gland development; regulation of blood vessel size; kidney development; skeletal development; ossification; Notch signaling pathway; somitogenesis; camera-type eye development; in utero embryonic development; regulation of organ growth; odontogenesis of dentine-containing teeth; eye development; embryonic heart tube development; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; brain development; vascular endothelial growth factor receptor signaling pathway; lymph vessel development
Reference #:  Q12948 (UniProtKB)
Alt. Names/Synonyms: ARA; FKHL7; forkhead box C1; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3
Gene Symbols: FOXC1
Molecular weight: 56,789 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXC1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
transcription, induced: S272‑p
activity, induced: S272‑p
protein stabilization: S272‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8 MQARYSVSsPNsLGV
0 1 S9-p QARYSVSsPNsLGVV
0 3 S12-p YSVSsPNsLGVVPYL
0 1 Y37 AAAAGGGYTAMPAPM
0 1 T38 AAAGGGYTAMPAPMS
1 10 T68-p ARAYGPYtPQPQPKD
0 1 K181 FKKKDAVKDKEEKDR
0 4 T228-p VRIQDIKtENGtCPs
0 4 T232-p DIKtENGtCPsPPQP
0 12 S235-p tENGtCPsPPQPLsP
0 14 S241-p PsPPQPLsPAAALGS
0 1 S248 sPAAALGSGSAAAVP
1 0 S272-p SSLSSGSsPPGSLPS
0 5 S320-p IMTSLRGsPQsAAAE
0 1 S323-p SLRGsPQsAAAELSs
0 1 S330-p sAAAELSsGLLAsAA
0 1 S335-p LSsGLLAsAAASSRA
0 3 S521-p QRIGLNNsPVNGNSS
  mouse

 
S8-p MQARYSVsSPNsLGV
S9 QARYSVsSPNsLGVV
S12-p YSVsSPNsLGVVPYL
Y37-p AAAAGGGytAMPAPM
T38-p AAAGGGytAMPAPMS
T68-p ARAYGPYtPQPQPKD
K181-ac FKKKDAVkDKEEKGR
T230-p VRIQDIKtENGtCPs
T234-p DIKtENGtCPsPPQP
S237-p tENGtCPsPPQPLsP
S243-p PsPPQPLsPAAALGs
S250-p sPAAALGsGSAATVP
S274 SSLSSGSSPPGSLPS
S320-p IMTSLRGsPQGSAAE
G323 SLRGsPQGSAAELGS
S330 GSAAELGSGLLASAA
S335 LGSGLLASAAASSRA
S521-p QRIGLNNsPVNGNSS
  rat

 
S8 MQARYSVSSPNSLGV
S9 QARYSVSSPNSLGVV
S12 YSVSSPNSLGVVPYL
Y37 AAAAGGGYTAMPAPM
T38 AAAGGGYTAMPAPMS
T68 ARAYGPYTPQPQPKD
K181 FKKKDAVKDKEEKGR
T230 VRIQDIKTENGTCPS
T234 DIKTENGTCPSPPQP
S237 TENGTCPSPPQPLSP
S243 PSPPQPLSPAAALGS
S250 SPAAALGSGSAATVP
S274 SSLSSGSSPPGSLPS
S320 IMTSLRGSPQGSAAE
G323 SLRGSPQGSAAELGS
S330 GSAAELGSGLLASAA
S335 LGSGLLASAAASSRA
S521 QRIGLNNSPVNGNSS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.