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Protein Page:
FOXC1 (human)

Overview
FOXC1 Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Cell cycle regulation; DNA binding protein; Cell development/differentiation
Cellular Component: transcription factor complex; nuclear heterochromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; chromatin DNA binding; double-stranded DNA binding; DNA bending activity; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; tissue development; collagen fibril organization; neural crest cell development; glycosaminoglycan metabolic process; paraxial mesoderm formation; heart development; positive regulation of transcription, DNA-dependent; cardiac muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of transcription factor activity; ovarian follicle development; ureteric bud development; germ cell migration; ventricular cardiac muscle morphogenesis; negative regulation of mitotic cell cycle; lacrimal gland development; regulation of blood vessel size; kidney development; skeletal development; Notch signaling pathway; somitogenesis; ossification; camera-type eye development; in utero embryonic development; regulation of organ growth; pattern specification process; odontogenesis of dentine-containing teeth; embryonic development; eye development; embryonic heart tube development; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; brain development; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptosis
Reference #:  Q12948 (UniProtKB)
Alt. Names/Synonyms: ARA; FKHL7; forkhead box C1; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3
Gene Symbols: FOXC1
Molecular weight: 56,789 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXC1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S272‑p
activity, induced: S272‑p
protein stabilization: S272‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12-p YSVSSPNsLGVVPYL
1 9 T68-p ARAYGPYtPQPQPKD
0 2 T228-p VRIQDIKtENGtCPs
0 2 T232-p DIKtENGtCPsPPQP
0 7 S235-p tENGtCPsPPQPLsP
0 8 S241-p PsPPQPLsPAAALGS
0 1 S248 sPAAALGSGSAAAVP
1 0 S272-p SSLSSGSsPPGSLPS
0 4 S320-p IMTSLRGsPQSAAAE
0 1 S521-p QRIGLNNsPVNGNSS
  mouse

 
S12-p YSVSSPNsLGVVPYL
T68-p ARAYGPYtPQPQPKD
T230-p VRIQDIKtENGtCPs
T234-p DIKtENGtCPsPPQP
S237-p tENGtCPsPPQPLsP
S243-p PsPPQPLsPAAALGs
S250-p sPAAALGsGSAATVP
S274 SSLSSGSSPPGSLPS
S320-p IMTSLRGsPQGSAAE
S521-p QRIGLNNsPVNGNSS
  rat

 
S12 YSVSSPNSLGVVPYL
T68 ARAYGPYTPQPQPKD
T230 VRIQDIKTENGTCPS
T234 DIKTENGTCPSPPQP
S237 TENGTCPSPPQPLSP
S243 PSPPQPLSPAAALGS
S250 SPAAALGSGSAATVP
S274 SSLSSGSSPPGSLPS
S320 IMTSLRGSPQGSAAE
S521 QRIGLNNSPVNGNSS
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