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Protein Page:
liprin alpha 2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
liprin alpha 2 Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Belongs to the liprin family. Liprin-alpha subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: cell surface; cytoplasm; synapse
Molecular Function: protein binding
Biological Process: cell-matrix adhesion
Reference #:  O75334 (UniProtKB)
Alt. Names/Synonyms: FLJ41378; LIPA2; liprin-alpha 2; Liprin-alpha-2; MGC132572; PPFIA2; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2; PTPRF-interacting protein alpha-2
Gene Symbols: PPFIA2
Molecular weight: 143,291 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Select Structure to View Below

liprin alpha 2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S163-p VVKRQAQsPSGVSSE
0 1 K229-u QNVHIQRkMASSEGS
0 1 S236 kMASSEGSTESEHLE
0 1 T237 MASSEGSTESEHLEG
0 1 S239 SSEGSTESEHLEGME
0 1 S257 KVHEKRLSNGSIDST
0 1 S260 EKRLSNGSIDSTDET
0 2 S538 QLKMRTGSLIEPTIP
0 1 P545 SLIEPTIPRTHLDTS
0 1 S558 TSAELRYSVGSLVDS
0 1 S558 TSAELRYSVGSLVDS
0 2 S687 EIENRVASVSLEGLN
0 7 S689 ENRVASVSLEGLNLA
0 2 S712-p TASVTASsLASSSPP
0 2 S716 TASsLASSSPPSGHS
0 2 S717 ASsLASSSPPSGHST
0 2 S720 LASSSPPSGHSTPKL
0 2 S723 SSPPSGHSTPKLTPR
0 6 S774 ATIKCETSPPPTPRA
0 2 T778 CETSPPPTPRALRMT
0 2 T787 RALRMTHTLPSSYHN
0 1 S817 GLGSANSSQDSLHKA
0 1 S820 SANSSQDSLHKAPKK
0 2 S966-p QEMVSLTsPSAPPTS
0 2 S1215-p GISMMPGsSETLPAG
  mouse

 
S163-p VVKRQAQsPSGVSSE
K229 QNVHIQRKMVSSEGs
S236-p KMVSSEGstEsEHLE
T237-p MVSSEGstEsEHLEG
S239-p SSEGstEsEHLEGME
S257-p KVHEKRLsNGsIDST
S260-p EKRLsNGsIDSTDDT
S538-p QMKMRTGsLIEPTIs
S545-gl sLIEPTIsRTHIDTS
S558-p TSTELRYsVGSLVDS
S558-gl TSTELRYsVGSLVDS
S687-p EIENRVAsVsLEGLN
S689-p ENRVAsVsLEGLNLA
S712-p TASVTASsLASssPP
S716-p TASsLASssPPsGHs
S717-p ASsLASssPPsGHsT
S720-p LASssPPsGHsTPKL
S723-p ssPPsGHsTPKLTPR
S774-p ATIKCETsPPPtPRA
T778-p CETsPPPtPRAVRMT
T787-p RAVRMTHtLPSSYHN
S817-p GLGSANSsQDsLHKA
S820-p SANSsQDsLHKAPKK
S966-p QEMVSLTsPSAPPTS
S1215 GISMMPGSSETLPAG
  rat

 
S163 VVKRQAQSPSGVSSE
K229 QNVHIQRKMVSSEGS
S236 KMVSSEGSTESEHLD
T237 MVSSEGSTESEHLDG
S239 SSEGSTESEHLDGME
S257 KVHEKRLSNGSIDST
S260 EKRLSNGSIDSTDDT
S538 QMKMRTGSLIEPTIS
S545 SLIEPTISRTHLDTS
S558 TSAELRYSVGSLVDS
S558 TSAELRYSVGSLVDS
S687 EIENRVASVSLEGLN
S689 ENRVASVSLEGLNLA
S712 TASVTASSLASSSPP
S716 TASSLASSSPPSGHS
S717 ASSLASSSPPSGHST
S720 LASSSPPSGHSTPKL
S723 SSPPSGHSTPKLTPR
S774 ATIKCETSPPPTPRA
T778 CETSPPPTPRAIRMT
T787 RAIRMTHTLPSSYHN
S817 GLGSANSSQDSLHKA
S820 SANSSQDSLHKAPKK
S966 QEMVSLTSPSAPPTS
S1215 GISMMPGSSETLPAG
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