Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
COX4I1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
COX4I1 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Ubiquitous. Belongs to the cytochrome c oxidase IV family. Note: This description may include information from UniProtKB.
Protein type: Energy Metabolism - oxidative phosphorylation; EC 1.9.3.1; Oxidoreductase; Mitochondrial; Membrane protein, integral
Cellular Component: mitochondrion; mitochondrial inner membrane; nucleus
Molecular Function: cytochrome-c oxidase activity
Biological Process: generation of precursor metabolites and energy; response to nutrient
Reference #:  P13073 (UniProtKB)
Alt. Names/Synonyms: COX IV-1; COX4; COX41; COX4I1; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase subunit IV isoform 1; MGC72016
Gene Symbols: COX4I1
Molecular weight: 19,577 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX4I1
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K12-m1 RVFSLVGkRAISTSV
0 1 S26-p VCVRAHEsVVkSEDF
0 3 K29-a RAHEsVVkSEDFSLP
0 2 K29-u RAHEsVVkSEDFSLP
0 2 F33 sVVkSEDFSLPAYMD
0 1 K53-a LPEVAHVkHLSASQk
0 1 K53-u LPEVAHVkHLSASQk
1 5 S58 HVkHLSASQkALkEK
0 2 K60-a kHLSASQkALkEKEk
0 1 K60 kHLSASQKALkEKEk
0 1 K63-m1 SASQkALkEKEkASW
0 4 K67-a kALkEKEkASWSsLS
0 4 S72-p KEkASWSsLSMDEKV
1 1 S74 kASWSsLSMDEKVEL
0 8 K87-a ELYRIKFkEsFAEMN
0 1 S89-p YRIKFkEsFAEMNRG
0 2 K135-u PLPQSFDkEWVAKQT
0 1 K143 EWVAKQTKRMLDMkV
0 4 K149-u TKRMLDMkVNPIQGL
0 2 S158-p NPIQGLAskWDYEkN
0 1 K159-u PIQGLAskWDYEkNE
0 1 K164-u AskWDYEkNEWkK__
0 1 K164 AskWDYEKNEWkK__
0 2 K168-a DYEkNEWkK______
0 2 K169 YEkNEWkK_______
  mouse

 
K12 RALSLIGKRAISTSV
S26 VCLRAHGSVVkSEDy
K29-a RAHGSVVkSEDyAFP
K29-u RAHGSVVkSEDyAFP
Y33-p SVVkSEDyAFPTYAD
T53 LPDVAHVTMLSAsQk
T53 LPDVAHVTMLSAsQk
S58-p HVTMLSAsQkALKEK
K60-a TMLSAsQkALKEKEk
K60-u TMLSAsQkALKEKEk
K63 SAsQkALKEKEkADW
K67-a kALKEKEkADWSsLS
S72-p KEkADWSsLSRDEKV
S74 kADWSsLSRDEKVQL
N87 QLYRIQFNESFAEMN
S89 YRIQFNESFAEMNRG
R135 PIPHTFDRDWVAMQT
K143-a DWVAMQTkRMLDMkA
K149-u TkRMLDMkANPIQGF
A158 NPIQGFSAKWDYDkN
K159 PIQGFSAKWDYDkNE
K164 SAKWDYDKNEWkk__
K164-a SAKWDYDkNEWkk__
K168-a DYDkNEWkk______
K169-a YDkNEWkk_______
  rat

 
K12 RALSLIGKRAISTSV
S26 VCLRAHGSVVKSEDY
K29 RAHGSVVKSEDYALP
K29 RAHGSVVKSEDYALP
Y33 SVVKSEDYALPSYVD
K53 LPDVAHVKLLSAsQK
K53 LPDVAHVKLLSAsQK
S58-p HVKLLSAsQKALKEK
K60 KLLSAsQKALKEKEK
K60 KLLSAsQKALKEKEK
K63 SAsQKALKEKEKADW
K67 KALKEKEKADWSSLS
S72 KEKADWSSLSRDEKV
S74 KADWSSLSRDEKVQL
N87 QLYRIQFNESFAEMN
S89 YRIQFNESFAEMNKG
R135 PIPHTFDRDWVAMQT
K143 DWVAMQTKRMLDMKV
K149 TKRMLDMKVNPIQGF
A158 NPIQGFSAKWDYNKN
K159 PIQGFSAKWDYNKNE
K164 SAKWDYNKNEWKK__
K164 SAKWDYNKNEWKK__
K168 DYNKNEWKK______
K169 YNKNEWKK_______
  rabbit

 
S12 RLLSFSGSRAISTSF
S26 FCLRAHGSVVKSEDY
K29 RAHGSVVKSEDYALP
K29 RAHGSVVKSEDYALP
Y33 SVVKSEDYALPSYVD
K53 LPDVAHVKQLSAGQK
K53 LPDVAHVKQLSAGQK
G58 HVKQLSAGQKALKEK
K60 KQLSAGQKALKEKEK
K60 KQLSAGQKALKEKEK
K63 SAGQKALKEKEKAPW
K67 KALKEKEKAPWGSLt
S72 KEKAPWGSLtRDEKV
T74-p KAPWGSLtRDEKVEL
N87 ELYRIQFNESFAEMN
S89 YRIQFNESFAEMNRG
K135 PIPHTFDKEWVAMQT
K143 EWVAMQTKRMLDMKV
K149 TKRMLDMKVSPIQGF
A158 SPIQGFSAKWDYNKN
K159 PIQGFSAKWDYNKNE
K164 SAKWDYNKNEWRK__
K164 SAKWDYNKNEWRK__
R168 DYNKNEWRK______
K169 YNKNEWRK_______
  cow

 
R12 RVFSLIGRRAISTSV
S26 VCVRAHGSVVKSEDy
K29 RAHGSVVKSEDyALP
K29 RAHGSVVKSEDyALP
Y33-p SVVKSEDyALPSYVD
K53 LPDVAHVKNLSAsQK
K53 LPDVAHVKNLSAsQK
S58-p HVKNLSAsQKALKEK
K60 KNLSAsQKALKEKEK
K60 KNLSAsQKALKEKEK
K63 SAsQKALKEKEKASW
K67 KALKEKEKASWSSLS
S72 KEKASWSSLSIDEKV
S74 KASWSSLSIDEKVEL
K87 ELYRLKFKESFAEMN
S89 YRLKFKESFAEMNRS
E135 PIPHTFEEEWVAKQT
K143 EWVAKQTKRMLDMKV
K149 TKRMLDMKVAPIQGF
A158 APIQGFSAKWDYDKN
K159 PIQGFSAKWDYDKNE
K164 SAKWDYDKNEWKK__
K164 SAKWDYDKNEWKK__
K168 DYDKNEWKK______
K169 YDKNEWKK_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.