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Protein Page:
COX4I1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
COX4I1 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Ubiquitous. Belongs to the cytochrome c oxidase IV family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; EC 1.9.3.1
Cellular Component: mitochondrion; membrane; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; cytochrome-c oxidase activity
Biological Process: cellular metabolic process; generation of precursor metabolites and energy; response to nutrient
Reference #:  P13073 (UniProtKB)
Alt. Names/Synonyms: COX IV-1; COX4; COX41; COX4I1; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase subunit IV isoform 1; MGC72016
Gene Symbols: COX4I1
Molecular weight: 19,577 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX4I1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K12-m1 RVFSLVGkRAISTSV
0 2 S26-p VCVRAHEsVVksEDF
0 4 K29 RAHEsVVKsEDFsLP
0 2 K29-ub RAHEsVVksEDFsLP
0 1 K29 RAHEsVVKsEDFsLP
0 2 S30-p AHEsVVksEDFsLPA
0 2 F33 sVVksEDFsLPAyMD
0 1 S34-p VVksEDFsLPAyMDR
0 1 Y38-p EDFsLPAyMDRRDHP
0 2 K53-ac LPEVAHVkHLSASQk
0 1 K53-ub LPEVAHVkHLSASQk
1 5 S58 HVkHLSASQkALkEK
0 3 K60-ac kHLSASQkALkEKEk
0 1 K60 kHLSASQKALkEKEk
0 1 K60 kHLSASQKALkEKEk
0 1 K63-m1 SASQkALkEKEkASW
0 1 K65 SQkALkEKEkASWSs
0 5 K67-ac kALkEKEkASWSsLS
0 2 K67-sc kALkEKEkASWSsLS
0 4 S72-p KEkASWSsLSMDEKV
1 1 S74 kASWSsLSMDEKVEL
0 1 K78 SsLSMDEKVELYRIK
0 9 K87-ac ELYRIKFkEsFAEMN
0 1 K87-sc ELYRIKFkEsFAEMN
0 1 S89-p YRIKFkEsFAEMNRG
0 1 S132-p VYGPLPQsFDkEWVA
0 2 K135-ub PLPQsFDkEWVAKQT
0 1 K143 EWVAKQTKRMLDMkV
0 4 K149-ub TKRMLDMkVNPIQGL
0 1 K149 TKRMLDMKVNPIQGL
0 3 S158-p NPIQGLAskWDYEkN
0 1 K159 PIQGLAsKWDYEkNE
0 1 K159-ub PIQGLAskWDYEkNE
0 1 K159 PIQGLAsKWDYEkNE
0 1 K164-ub AskWDYEkNEWkK__
0 1 K164 AskWDYEKNEWkK__
0 2 K164 AskWDYEKNEWkK__
0 2 K168-ac DYEkNEWkK______
0 2 K169 YEkNEWkK_______
  mouse

 
K12 RALSLIGKRAISTSV
S26-p VCLRAHGsVVkSEDy
K29-ac RAHGsVVkSEDyAFP
K29-ub RAHGsVVkSEDyAFP
K29-sc RAHGsVVkSEDyAFP
S30 AHGsVVkSEDyAFPT
Y33-p sVVkSEDyAFPTYAD
A34 VVkSEDyAFPTYADR
Y38 EDyAFPTYADRRDYP
T53 LPDVAHVTMLSAsQk
T53 LPDVAHVTMLSAsQk
S58-p HVTMLSAsQkALKEk
K60-ac TMLSAsQkALKEkEk
K60-ub TMLSAsQkALKEkEk
K60-sc TMLSAsQkALKEkEk
K63 SAsQkALKEkEkADW
K65-sc sQkALKEkEkADWSs
K67-ac kALKEkEkADWSsLS
K67-sc kALKEkEkADWSsLS
S72-p kEkADWSsLSRDEkV
S74 kADWSsLSRDEkVQL
K78-ac SsLSRDEkVQLYRIQ
N87 QLYRIQFNESFAEMN
N87 QLYRIQFNESFAEMN
S89 YRIQFNESFAEMNRG
T132 VYGPIPHTFDRDWVA
R135 PIPHTFDRDWVAMQT
K143-ac DWVAMQTkRMLDMkA
K149-ub TkRMLDMkANPIQGF
K149-sc TkRMLDMkANPIQGF
A158 NPIQGFSAkWDYDkN
K159-ac PIQGFSAkWDYDkNE
K159 PIQGFSAKWDYDkNE
K159-sc PIQGFSAkWDYDkNE
K164 SAkWDYDKNEWkk__
K164-sc SAkWDYDkNEWkk__
K164-ac SAkWDYDkNEWkk__
K168-ac DYDkNEWkk______
K169-ac YDkNEWkk_______
  rat

 
K12 RALSLIGKRAISTSV
S26 VCLRAHGSVVksEDY
K29-ac RAHGSVVksEDYALP
K29 RAHGSVVKsEDYALP
K29 RAHGSVVKsEDYALP
S30-p AHGSVVksEDYALPS
Y33 SVVksEDYALPSYVD
A34 VVksEDYALPSYVDR
Y38 EDYALPSYVDRRDYP
K53-ac LPDVAHVkLLSAsQk
K53 LPDVAHVKLLSAsQk
S58-p HVkLLSAsQkALKEK
K60-ac kLLSAsQkALKEKEk
K60 kLLSAsQKALKEKEk
K60 kLLSAsQKALKEKEk
K63 SAsQkALKEKEkADW
K65 sQkALKEKEkADWSs
K67-ac kALKEKEkADWSsLS
K67 kALKEKEKADWSsLS
S72-p KEkADWSsLSRDEkV
S74 kADWSsLSRDEkVQL
K78-ac SsLSRDEkVQLYRIQ
N87 QLYRIQFNESFAEMN
N87 QLYRIQFNESFAEMN
S89 YRIQFNESFAEMNKG
T132 VYGPIPHTFDRDWVA
R135 PIPHTFDRDWVAMQT
K143 DWVAMQTKRMLDMKV
K149 TKRMLDMKVNPIQGF
K149 TKRMLDMKVNPIQGF
A158 NPIQGFSAkWDYNkN
K159-ac PIQGFSAkWDYNkNE
K159 PIQGFSAKWDYNkNE
K159 PIQGFSAKWDYNkNE
K164 SAkWDYNKNEWkK__
K164 SAkWDYNKNEWkK__
K164-ac SAkWDYNkNEWkK__
K168-ac DYNkNEWkK______
K169 YNkNEWkK_______
  rabbit

 
S12 RLLSFSGSRAISTSF
S26 FCLRAHGSVVKSEDY
K29 RAHGSVVKSEDYALP
K29 RAHGSVVKSEDYALP
K29 RAHGSVVKSEDYALP
S30 AHGSVVKSEDYALPS
Y33 SVVKSEDYALPSYVD
A34 VVKSEDYALPSYVDR
Y38 EDYALPSYVDRRDYP
K53 LPDVAHVKQLSAGQK
K53 LPDVAHVKQLSAGQK
G58 HVKQLSAGQKALKEK
K60 KQLSAGQKALKEKEK
K60 KQLSAGQKALKEKEK
K60 KQLSAGQKALKEKEK
K63 SAGQKALKEKEKAPW
K65 GQKALKEKEKAPWGS
K67 KALKEKEKAPWGSLt
K67 KALKEKEKAPWGSLt
S72 KEKAPWGSLtRDEKV
T74-p KAPWGSLtRDEKVEL
K78 GSLtRDEKVELYRIQ
N87 ELYRIQFNESFAEMN
N87 ELYRIQFNESFAEMN
S89 YRIQFNESFAEMNRG
T132 VYGPIPHTFDKEWVA
K135 PIPHTFDKEWVAMQT
K143 EWVAMQTKRMLDMKV
K149 TKRMLDMKVSPIQGF
K149 TKRMLDMKVSPIQGF
A158 SPIQGFSAKWDYNKN
K159 PIQGFSAKWDYNKNE
K159 PIQGFSAKWDYNKNE
K159 PIQGFSAKWDYNKNE
K164 SAKWDYNKNEWRK__
K164 SAKWDYNKNEWRK__
K164 SAKWDYNKNEWRK__
R168 DYNKNEWRK______
K169 YNKNEWRK_______
  cow

 
R12 RVFSLIGRRAISTSV
S26 VCVRAHGSVVKSEDy
K29 RAHGSVVKSEDyALP
K29 RAHGSVVKSEDyALP
K29 RAHGSVVKSEDyALP
S30 AHGSVVKSEDyALPS
Y33-p SVVKSEDyALPSYVD
A34 VVKSEDyALPSYVDR
Y38 EDyALPSYVDRRDYP
K53 LPDVAHVKNLSAsQK
K53 LPDVAHVKNLSAsQK
S58-p HVKNLSAsQKALKEK
K60 KNLSAsQKALKEKEK
K60 KNLSAsQKALKEKEK
K60 KNLSAsQKALKEKEK
K63 SAsQKALKEKEKASW
K65 sQKALKEKEKASWSS
K67 KALKEKEKASWSSLS
K67 KALKEKEKASWSSLS
S72 KEKASWSSLSIDEKV
S74 KASWSSLSIDEKVEL
K78 SSLSIDEKVELYRLK
K87 ELYRLKFKESFAEMN
K87 ELYRLKFKESFAEMN
S89 YRLKFKESFAEMNRS
T132 VYGPIPHTFEEEWVA
E135 PIPHTFEEEWVAKQT
K143 EWVAKQTKRMLDMKV
K149 TKRMLDMKVAPIQGF
K149 TKRMLDMKVAPIQGF
A158 APIQGFSAKWDYDKN
K159 PIQGFSAKWDYDKNE
K159 PIQGFSAKWDYDKNE
K159 PIQGFSAKWDYDKNE
K164 SAKWDYDKNEWKK__
K164 SAKWDYDKNEWKK__
K164 SAKWDYDKNEWKK__
K168 DYDKNEWKK______
K169 YDKNEWKK_______
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