Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pyruvate; EC 126.96.36.199; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 188.8.131.52; Oxidoreductase
Cellular Component: peroxisomal matrix; cytoplasm
Molecular Function: glyoxylate reductase (NADP) activity; protein homodimerization activity; NAD binding; hydroxypyruvate reductase activity; glycerate dehydrogenase activity
Biological Process: metabolic process; glyoxylate metabolic process; excretion; protein oligomerization
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.