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Protein Page:
GRHPR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GRHPR Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Oxidoreductase; EC 1.1.1.79; Carbohydrate Metabolism - pyruvate; EC 1.1.1.81
Cellular Component: peroxisomal matrix; cytoplasm; cytosol
Molecular Function: glyoxylate reductase (NADP) activity; protein homodimerization activity; carboxylic acid binding; NAD binding; hydroxypyruvate reductase activity; glycerate dehydrogenase activity
Biological Process: dicarboxylic acid metabolic process; metabolic process; glyoxylate metabolic process; excretion; protein oligomerization
Reference #:  Q9UBQ7 (UniProtKB)
Alt. Names/Synonyms: GLXR; glycerate-2-dehydrogenase; GLYD; Glyoxylate reductase/hydroxypyruvate reductase; GRHPR; PH2
Gene Symbols: GRHPR
Molecular weight: 35,668 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
Select Structure to View Below

GRHPR

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S36-p CEVEQWDsDEPIPAK
0 43 K65-a LLSDHVDkRILDAAG
0 1 K94 HLALDEIKKRGIRVG
0 1 K173 QAIARRLKPFGVQRF
0 19 Y255-p VVNQDDLyQALASGk
0 1 K262-u yQALASGkIAAAGLD
0 1 R300 HIGSATHRTRNTMSL
0 2 K327-a EPMPSELkL______
  mouse

 
S36 CEVEQWNSDDPIPRK
K65 RLSDRVDKKLLDAAG
K94-u HLALDEIkKRGIRVG
K173-u QAIARRLkPFGVQRF
Y255 VVNQEDLYQALASGQ
Q262 YQALASGQIAAAGLD
K300-u HIGSATYkTRNTMSL
K327 EAMPSELKL______
  rat

 
S43 CEVEQWNSDDPIPSK
K72 RLSDRVDKKLLDAAG
K101 HLALDEIKKRGIRVG
K180 QAIARRLKPFGVQRF
Y262 VVNQEDLYQALASGQ
Q269 YQALASGQIAAAGLD
K307 HIGSAtYKTRNTMSL
K334 EPMPSELKL______
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