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Protein Page:
DR1 (human)

Overview
DR1 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Belongs to the NC2 beta/DR1 family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; TATA-binding protein binding; protein heterodimerization activity; transcription factor binding; transcription corepressor activity
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q01658 (UniProtKB)
Alt. Names/Synonyms: Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); DR1; NC2; NC2-beta; NC2B; Negative cofactor 2-beta; Protein Dr1; TATA-binding protein-associated phosphoprotein
Gene Symbols: DR1
Molecular weight: 19,444 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DR1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S3-p _____MAsSsGNDDD
0 1 S5-p ___MAsSsGNDDDLT
0 1 T25 INKMIKETLPNVRVA
0 1 S67-p KSEKKTIsPEHVIQA
0 3 T96-p EVLQECKtVALKRRK
0 153 S105-p ALKRRKAssRLENLG
0 7 S106-p LKRRKAssRLENLGI
0 1 S166-p SASNQAGssQDEEDD
0 1 S167-p ASNQAGssQDEEDDD
  mouse

 
S3 _____MASSSGNDDD
S5 ___MASSSGNDDDLT
T25-p INKMIKEtLPNVRVA
S67 KSEKKTISPEHVIQA
T96 EVLQECKTVALKRRK
S105-p ALKRRKAssRLENLG
S106-p LKRRKAssRLENLGI
S166 SASTQAGSSQDEEDD
S167 ASTQAGSSQDEEDDD
  rat

 
S3 _____MASSSGNDDD
S5 ___MASSSGNDDDLT
T25 INKMIKETLPNVRVA
S67 KSEKKTISPEHVIQA
T96 EVLQECKTVALKRRK
S105-p ALKRRKAsSRLENLG
S106 LKRRKAsSRLENLGI
S166 SASNQAGSSQDEDDD
S167 ASNQAGSSQDEDDDD
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