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MCM7 (human)

Overview MCM7 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6- MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR- ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Belongs to the MCM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; EC 3.6.4.12; DNA replication Cellular Component: nucleoplasm; MCM complex; chromatin Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; single-stranded DNA binding; ATP binding Biological Process: DNA unwinding during replication; cell proliferation; regulation of phosphorylation; DNA replication initiation; M/G1 transition of mitotic cell cycle; DNA strand elongation during DNA replication; mitotic cell cycle; S phase of mitotic cell cycle; DNA replication; cell cycle checkpoint; response to DNA damage stimulus; G1/S transition of mitotic cell cycle Reference #:  P33993 (UniProtKB) Alt. Names/Synonyms: CDC47; CDC47 homolog; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; MCM2; MCM7; minichromosome maintenance complex component 7; minichromosome maintenance deficient 7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146 Gene Symbols: MCM7 Molecular weight: 81,308 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MCM7

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K4-u	____MALkDyALEkE
0	1		Y6-p	__MALkDyALEkEKV
0	6		K10-u	LkDyALEkEKVKkFL
0	3		K15-u	LEkEKVKkFLQEFYQ
0	51		K28-u	YQDDELGkkQFkYGN
0	8		K28-a	YQDDELGkkQFkYGN
0	22		K29-u	QDDELGkkQFkYGNQ
0	1		K29-a	QDDELGkkQFkYGNQ
0	3		K32-u	ELGkkQFkYGNQLVR
0	4		K75-u	ENARRYAkLFADAVQ
0	14		K89-u	QELLPQYkEREVVNk
0	1		K96-u	kEREVVNkDVLDVYI
0	1		S113-p	RLMMEQRsRDPGMVR
0	7		S121-p	RDPGMVRsPQNQYPA
0	59		K145-u	FQGPSSNkPRVIREV
0	16		K159-u	VRADSVGkLVTVRGI
0	2		K174-u	VTRVSEVkPKMVVAT
0	5		K231-u	TRGSRFIkFQEMkMQ
0	4		K236-u	FIkFQEMkMQEHSDQ
0	1		K305-u	LEAHRIVkMNksEDD
0	9		K308-u	HRIVkMNksEDDEsG
0	1		S309-p	RIVkMNksEDDEsGA
0	2		S314-p	NksEDDEsGAGELtR
0	1		T320-p	EsGAGELtREELRQI
0	1		R321	sGAGELtREELRQIA
0	1		K335-u	AEEDFYEkLAASIAP
0	2		K351-u	IYGHEDVkkALLLLL
0	2		K352-u	YGHEDVkkALLLLLV
1	1		S365-p	LVGGVDQsPRGMKIR
0	26		K387-u	MGDPGVAkSQLLsYI
0	1		S388	GDPGVAkSQLLsYID
0	1		S392-p	VAkSQLLsYIDRLAP
0	1		T466	HEVMEQQTISIAkAG
0	1		S468	VMEQQTISIAkAGIL
0	3		K471-u	QQTISIAkAGILTTL
0	12		Y492-p	LAAANPAyGRYNPRR
0	6		S500-p	GRYNPRRsLEQNIQL
0	1		S549-p	QHSRQPPsQFEPLDM
0	4		K557-u	QFEPLDMkLMRRYIA
0	6		K569-u	YIAMCREkQPMVPES
0	1		Y580-p	VPESLADyITAAYVE
0	16		K596-u	RREAWASkDATyTSA
0	34		Y600-p	WASkDATyTSARTLL
0	17		K627-u	RMVDVVEkEDVNEAI
0	4		K641-u	IRLMEMSkDSLLGDk
0	17		K648-u	kDSLLGDkGQTARTQ
0	1		S674	ELVSGGRSVRFSEAE

	mouse
K4	____MALKDYAIEKE
Y6	__MALKDYAIEKEKV
K10	LKDYAIEKEKVKKFL
K15	IEKEKVKKFLQEFYY
K28-u	YYENELGkKQFkYGT
K28	YYENELGKKQFkYGT
K29	YENELGkKQFkYGTQ
K29	YENELGkKQFkYGTQ
K32-u	ELGkKQFkYGTQLVH
R75	ENAKRYSRLFGDVVQ
K89	QELLPEYKEKEVVNK
K96	KEKEVVNKDVLDVYI
S113	RLMMEQRSRDPGAVR
N121	RDPGAVRNPQNQYPS
K145	FRGPSSSKPRVIREV
K159	VRADSVGKLLTVRGI
K174	VTRVSEVKPRMVVAT
K231	TRGSKFVKFQEMKIQ
K236	FVKFQEMKIQEHSDQ
K305	LEAHWIVKMTKSDDD
K308	HWIVKMTKSDDDVsG
S309	WIVKMTKSDDDVsGA
S314-p	TKSDDDVsGAGELSs
S320	VsGAGELSsEELKQI
S321-p	sGAGELSsEELKQIA
K335	AEEDFYEKLAASIAP
K351	IYGHEDVKKALLLLL
K352	YGHEDVKKALLLLLV
S365	LVGGVDQSPQGMKIR
K387	MGDPGVAKsQLLSYI
S388-p	GDPGVAKsQLLSYID
S392	VAKsQLLSYIDRLAP
T466-p	HEVMEQQtIsIAKAG
S468-p	VMEQQtIsIAKAGIL
K471	QQtIsIAKAGILTTL
Y492-p	LAAANPAyGRYNPRR
S500-p	GRYNPRRsLEQNVQL
A549	QHSRQPPAQFEPLDM
K557	QFEPLDMKLMRRYIA
R569	YIAMCHERQPTVPES
Y580	VPESLADYITAAYVE
K596	RREARASKDATYTSA
Y600	RASKDATYTSARTLL
K627	RMVDIVEKEDVNEAI
K641	IRLMEMSKDSLLGEk
K648-u	KDSLLGEkGQTARTQ
S674-p	ELVSRGRsVHFSEAE

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