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Protein Page:
MCM7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MCM7 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6- MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR- ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Belongs to the MCM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Motility/polarity/chemotaxis; DNA replication
Cellular Component: nucleoplasm; membrane; MCM complex; cytoplasm; nucleolus; cytosol; nucleus; chromatin
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; single-stranded DNA binding; ATP binding
Biological Process: DNA unwinding during replication; response to drug; cell proliferation; regulation of phosphorylation; DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication; response to DNA damage stimulus; G1/S transition of mitotic cell cycle
Reference #:  P33993 (UniProtKB)
Alt. Names/Synonyms: CDC47; CDC47 homolog; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; MCM2; MCM7; minichromosome maintenance complex component 7; minichromosome maintenance deficient 7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146
Gene Symbols: MCM7
Molecular weight: 81,308 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCM7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ub ____MALkDyALEkE
0 1 K4-sc ____MALkDyALEkE
0 1 Y6-p __MALkDyALEkEKV
0 6 K10-ub LkDyALEkEKVKkFL
0 1 K10-sc LkDyALEkEKVKkFL
0 3 K15-ub LEkEKVKkFLQEFYQ
0 51 K28-ub YQDDELGkkQFkYGN
0 9 K28-ac YQDDELGkkQFkYGN
0 22 K29-ub QDDELGkkQFkYGNQ
0 1 K29-ac QDDELGkkQFkYGNQ
0 3 K32-ub ELGkkQFkYGNQLVR
0 4 K75-ub ENARRYAkLFADAVQ
0 14 K89-ub QELLPQYkEREVVNk
0 1 K96-ub kEREVVNkDVLDVYI
0 1 S113-p RLMMEQRsRDPGMVR
1 10 S121-p RDPGMVRsPQNQYPA
0 59 K145-ub FQGPSSNkPRVIREV
0 16 K159-ub VRADSVGkLVTVRGI
0 1 T168-p VTVRGIVtRVSEVkP
0 2 K174-ub VtRVSEVkPKMVVAT
0 5 K231-ub TRGSRFIkFQEMkMQ
0 4 K236-ub FIkFQEMkMQEHSDQ
0 1 K305-ub LEAHRIVkMNksEDD
0 9 K308-ub HRIVkMNksEDDEsG
0 1 S309-p RIVkMNksEDDEsGA
0 5 S314-p NksEDDEsGAGELtR
0 3 T320-p EsGAGELtREELRQI
0 1 R321 sGAGELtREELRQIA
0 1 Y333-p QIAEEDFyEkLAASI
0 1 K335-ub AEEDFyEkLAASIAP
0 2 K351-ub IYGHEDVkkALLLLL
0 1 K351-sc IYGHEDVkkALLLLL
0 2 K352-ub YGHEDVkkALLLLLV
2 2 S365-p LVGGVDQsPRGMKIR
0 26 K387-ub MGDPGVAksQLLsYI
0 2 S388-p GDPGVAksQLLsYID
0 2 S392-p VAksQLLsYIDRLAP
0 1 T466 HEVMEQQTISIAkAG
0 1 S468 VMEQQTISIAkAGIL
0 3 K471-ub QQTISIAkAGILTTL
0 13 Y492-p LAAANPAyGRYNPRR
0 8 S500-p GRYNPRRsLEQNIQL
0 1 S549-p QHSRQPPsQFEPLDM
0 4 K557-ub QFEPLDMkLMRRYIA
0 6 K569-ub YIAMCREkQPMVPES
0 1 Y580-p VPESLADyITAAYVE
0 16 K596-ub RREAWASkDAtyTSA
0 1 T599-p AWASkDAtyTSARtL
1 37 Y600-p WASkDAtyTSARtLL
0 1 T605-p AtyTSARtLLAILRL
0 17 K627-ub RMVDVVEkEDVNEAI
0 4 K641-ub IRLMEMSkDSLLGDk
0 17 K648-ub kDSLLGDkGQTARTQ
0 3 S674-p ELVSGGRsVRFsEAE
0 2 S678-p GGRsVRFsEAEQRCV
  mouse

 
K4 ____MALKDYAIEKE
K4 ____MALKDYAIEKE
Y6 __MALKDYAIEKEKV
K10 LKDYAIEKEKVKKFL
K10 LKDYAIEKEKVKKFL
K15 IEKEKVKKFLQEFYY
K28-ub YYENELGkKQFkYGT
K28 YYENELGKKQFkYGT
K29 YENELGkKQFkYGTQ
K29 YENELGkKQFkYGTQ
K32-ub ELGkKQFkYGTQLVH
R75 ENAKRYSRLFGDVVQ
K89 QELLPEYKEKEVVNK
K96 KEKEVVNKDVLDVYI
S113 RLMMEQRSRDPGAVR
N121 RDPGAVRNPQNQYPS
K145 FRGPSSSKPRVIREV
K159 VRADSVGKLLTVRGI
T168 LTVRGIVTRVSEVKP
K174 VTRVSEVKPRMVVAT
K231 TRGSKFVKFQEMKIQ
K236 FVKFQEMKIQEHSDQ
K305 LEAHWIVKMTKSDDD
K308 HWIVKMTKSDDDVsG
S309 WIVKMTKSDDDVsGA
S314-p TKSDDDVsGAGELSs
S320 VsGAGELSsEELKQI
S321-p sGAGELSsEELKQIA
Y333 QIAEEDFYEKLAASI
K335 AEEDFYEKLAASIAP
K351 IYGHEDVKKALLLLL
K351 IYGHEDVKKALLLLL
K352 YGHEDVKKALLLLLV
S365 LVGGVDQSPQGMKIR
K387 MGDPGVAKsQLLSYI
S388-p GDPGVAKsQLLSYID
S392 VAKsQLLSYIDRLAP
T466-p HEVMEQQtIsIAKAG
S468-p VMEQQtIsIAKAGIL
K471 QQtIsIAKAGILTTL
Y492-p LAAANPAyGRYNPRR
S500-p GRYNPRRsLEQNVQL
A549 QHSRQPPAQFEPLDM
K557 QFEPLDMKLMRRYIA
R569 YIAMCHERQPTVPES
Y580 VPESLADYITAAYVE
K596 RREARASKDATYTSA
T599 ARASKDATYTSARTL
Y600 RASKDATYTSARTLL
T605 ATYTSARTLLAILRL
K627 RMVDIVEKEDVNEAI
K641 IRLMEMSKDSLLGEk
K648-ub KDSLLGEkGQTARTQ
S674-p ELVSRGRsVHFSEAE
S678 RGRsVHFSEAEQRCI
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