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SP1 (human)

Overview SP1 a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease. Note: This description may include information from UniProtKB. Protein type: C2H2-type zinc finger protein; DNA binding protein; Transcription factor Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus Molecular Function: protein C-terminus binding; identical protein binding; protein homodimerization activity; zinc ion binding; histone deacetylase binding; transcription factor binding; histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; ossification; embryonic placenta development; transcription, DNA-dependent; megakaryocyte differentiation; positive regulation of transcription, DNA-dependent; embryonic skeletal development; embryonic process involved in female pregnancy; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; virus-host interaction; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; lung development Reference #:  P08047 (UniProtKB) Alt. Names/Synonyms: SP1; Sp1 transcription factor; specificity protein 1; Transcription factor Sp1; TSFP1 Gene Symbols: SP1 Molecular weight: 80,693 Da Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SP1 1SP1 - A=684-712 (human) 1SP2 - A=654-684 (human) 1VA1 - A=619-654 (human) 1VA2 - A=654-684 (human) 1VA3 - A=684-712 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1SP1 1SP2 1VA1 1VA2 1VA3  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: T278‑p, T739‑p transcription, altered: S59‑p, T278‑p, T453‑p, S641‑p, T739‑p transcription, inhibited: S59‑p, T739‑p activation: S641‑p intracellular localization: S101‑p molecular association, regulation: T453‑p, S641‑p, T739‑p O-GlcNAc glycosylation: S59‑p protein degradation: S7‑p, S59‑p, S728‑p, S732‑p protein stabilization: T278‑p, T739‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S2-p	______MsDQDHsMD
1	5		S7-p	_MsDQDHsMDEMTAV
2	0		K16-s	DEMTAVVkIEKGVGG
0	4		S36-p	GNGGGAFsQARSSsT
0	1		S41	AFsQARSSsTGSSSS
1	1		S42-p	FsQARSSsTGSSSST
2	0		S56-p	TGGGGQEsQPsPLAL
4	4		S59-p	GGQEsQPsPLALLAA
4	0		S101-p	DLTATQLsQGANGWQ
0	1		D199-ca	TGAQVQQdGSGQIQI
2	0		T278-p	SVSAATLtPSSQAVT
0	1		S307	TSGTTISSASLVSSQ
0	1		S318	VSSQASSSSFFTNAN
0	1		S319	SSQASSSSFFTNANS
6	0		T453-p	SGPIIIRtPTVGPNG
2	0		S491-g	LAPMQGVsLGQTSSS
0	1		S612	TCPYCKDSEGRGsGD
1	1		S612-g	TCPYCKDsEGRGsGD
0	1		S617-p	KDsEGRGsGDPGKKK
0	1		T640	CGKVYGKTsHLRAHL
1	1		T640-g	CGKVYGKtsHLRAHL
3	1		S641-p	GKVYGKtsHLRAHLR
1	1		S641-g	GKVYGKtsHLRAHLR
0	8		T651-p	RAHLRWHtGERPFMC
2	0		T668-p	SYCGKRFtRsDELQR
1	1		S670-p	CGKRFtRsDELQRHK
1	1		T679-p	ELQRHKRtHtGEKKF
2	2		T681-p	QRHKRtHtGEKKFAC
1	1		S698-p	CPKRFMRsDHLskHI
1	1		S698-g	CPKRFMRsDHLskHI
1	1		S702-p	FMRsDHLskHIKtHQ
1	1		S702-g	FMRsDHLskHIKtHQ
1	0		K703-a	MRsDHLskHIKtHQN
0	1		T707-p	HLskHIKtHQNKKGG
2	0		S728-p	VGTLPLDsGAGsEGS
2	0		S732-p	PLDsGAGsEGSGTAt
13	1		T739-p	sEGSGTAtPSALITT

	mouse
S2-p	______MsDQDHsMD
S7-p	_MsDQDHsMDEVTAV
K16	DEVTAVVKIEKDVGG
S37	NGGGAAFSQTRSssT
S42-p	AFSQTRSssTGSSSS
S43-p	FSQTRSssTGSSSSS
S58-p	GGGGGQEsQPsPLAL
S61-p	GGQEsQPsPLALLAA
S103	DLTATQLSQGANGWQ
D201	TGAQVQQDGSGQIQI
T280	SVSAATLTPSSQAGT
S309-p	TSGTAISsASLVSSQ
S320-p	VSSQASSssFFTNAN
S321-p	SSQASSssFFTNANS
T455	SGPIIIRTPTVGPNG
S493-g	LAPMQGVsLGQTSSS
S613	TCPYCKDSEGRASGD
S613	TCPYCKDSEGRASGD
S618	KDSEGRASGDPGKKK
T641	CGKVYGKTSHLRAHL
T641	CGKVYGKTSHLRAHL
S642	GKVYGKTSHLRAHLR
S642	GKVYGKTSHLRAHLR
T652	RAHLRWHTGERPFMC
T669	SYCGKRFTRSDELQR
S671	CGKRFTRSDELQRHK
T680	ELQRHKRTHTGEKKF
T682	QRHKRTHTGEKKFAC
S699	CPKRFMRSDHLSKHI
S699	CPKRFMRSDHLSKHI
S703	FMRSDHLSKHIKTHQ
S703	FMRSDHLSKHIKTHQ
K704	MRSDHLSKHIKTHQN
T708	HLSKHIKTHQNKKGG
S729	VGTLPLDSGAGSEGT
S733	PLDSGAGSEGTATPS
T738	AGSEGTATPSALITT

	rat
S2	______MSDQDHSMD
S7	_MSDQDHSMDEVTAV
K15	MDEVTAVKIEKGVGG
S36	NGGGAAFSQTRSSST
S41	AFSQTRSSSTGSSSS
S42	FSQTRSSSTGSSSSS
S57	GGGGGQESQPsPLAL
S60-p	GGQESQPsPLALLAA
S102	DLTATQLSQGANGWQ
D200	TGAQVQQDGSGQIQI
T279	SVSAATLTPSSQAGT
S308	TSGTAISSASLVSSQ
S319	VSSQASSSSFFTNAN
S320	SSQASSSSFFTNANS
T454-p	SGPIIIRtPTVGPNG
S492	LAPMQGVSLGQTSSS
S613-p	TCPYCKDsEGRGSGD
S613-g	TCPYCKDsEGRGSGD
S618	KDsEGRGSGDPGKKK
T641-p	CGKVYGKtsHLRAHL
T641-g	CGKVYGKtsHLRAHL
S642-p	GKVYGKtsHLRAHLR
S642-g	GKVYGKtsHLRAHLR
T652	RAHLRWHTGERPFMC
T669-p	SYCGKRFtRsDELQR
S671-p	CGKRFtRsDELQRHK
T680	ELQRHKRTHtGEKKF
T682-p	QRHKRTHtGEKKFAC
S699-p	CPKRFMRsDHLsKHI
S699-g	CPKRFMRsDHLsKHI
S703-p	FMRsDHLsKHIKTHQ
S703-g	FMRsDHLsKHIKTHQ
K704	MRsDHLsKHIKTHQN
T708	HLsKHIKTHQNKKGG
S729	VGTLPLDSGAGSEGS
S733	PLDSGAGSEGSGTAt
T740-p	SEGSGTAtPSALITT

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