a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA binding protein; Transcription factor
Molecular Function: protein C-terminus binding; identical protein binding; protein homodimerization activity; zinc ion binding; histone deacetylase binding; transcription factor binding; histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; ossification; embryonic placenta development; transcription, DNA-dependent; megakaryocyte differentiation; positive regulation of transcription, DNA-dependent; embryonic skeletal development; embryonic process involved in female pregnancy; enucleate erythrocyte differentiation; liver development; trophectodermal cell differentiation; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; virus-host interaction; gene expression; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.